Browsing Makale Koleksiyonu by Department "İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)"
Now showing items 61-80 of 299
-
Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
(Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Design of dense brush conformation bearing gold nanoparticles as theranostic agent for cancer
(Springer, 2019)Dense brush conformation–bearing theranostic agents are emerging as drug delivery systems due to their higher ability to escape from reticuloendothelial system uptake which prolongs their in vivo circulation time. With the ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
(Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
Development of a chemogenetic approach to manipulate intracellular pH
(American Chemical Society, 2023)Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. ... -
Development of acoustically active nanocones using the host-guest interaction as a new histotripsy agent
(American Chemical Society, 2019)Histotripsy is a noninvasive and nonthermal ultrasound ablation technique, which mechanically ablates the tissues using very short, focused, high-pressured ultrasound pulses to generate dense cavitating bubble cloud. ... -
Dietary zinc status in offspring of pregnant rats fed on a zinc-deficient diet is associated with Serum Albumin, Ast, and Alt levels
(Pera Publishing Services, 2023)Objective: This study was carried out to investigate whether dietary zinc status is associated with serum albumin, AST and ALT levels in male offspring of mother rats fed a zinc deficient diet. Methods: The study was ... -
The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses
(Elsevier Science Bv, 2019)Event-related oscillatory responses reflect the cognitive status in many neuropsychiatric conditions including mild cognitive impairment (MCI). In this study, a total of 30 patients with amnestic MCI (aMCI) and 25 patients ... -
Different concentrations of mesna application have an effect on the internal ear?
(Elsevier Ireland Ltd, 2018)Objective: The use of Mesna as a chemical dissector in higher concentrations may reduce the length of time of operation by providing more effective dissection as well as being used in otologic pathologies such as ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
(Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
(Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
Differentiation of inflammation-responsive astrocytes from glial progenitors generated from human induced pluripotent stem cells
(Cell Press, 2017)Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of ... -
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
(John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor
(National Academy of Sciences, 2017)Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal transduction pathways emanating from ... -
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
(Nature Research, 2022)Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease ... -
Distinct brain oscillatory responses for the perception and identification of one's own body from other's body
(Springer, 2021)The body recognition process includes complex visual processing, the sensation, perception, and distinction stages of the stimulus. This study examined this process by using the time-frequency analysis of EEG signals and ... -
DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients
(Bentham Science Publishers, 2022)Background: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes ... -
Does a microfluidic chip for sperm sorting have a positive add-on effect on laboratory and clinical outcomes of intracytoplasmic sperm injection cycles? A sibling oocyte study
(Wiley, 2019)The most recent technologies for sperm sorting involve microfluidics. However, the most important question whether their use is of any advantage in terms of laboratory and clinical IVF/ICSI outcomes still remains controversy. ... -
Does Ramadan fasting have effects on sleep, fatigue and blood pressure among patients with hypertension?
(NLM (Medline), 2021)AIM: The aim of this study was to determine the effect of Ramadan fasting on blood pressure (BP), fatigue, sleeping and physical activity among hypertensive patients. SUBJECTS AND METHODS: A cross-sectional study was ... -
Dondurulmuş ejekülat ve dondurulmuş testiküler spermin sonuçlarının intrasitoplazmik sperm enjeksiyonu (ICSI) parametrelerine etkisinin değerlendirilmesi
(Avrasya Üroonkoloji Derneği, 2019)Amaç: Çalışmamızda, dondurulmuş ejekülat ve dondurulmuş testiküler spermin İntrasitoplaz - mik Sperm Enjeksiyonu (ICSI) sonuçları üzerine etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmamızda 11.10.2016- ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
(Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ...