Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Günal, Mehmet Yalçın
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CitationKeskin, İ., Günal, M. Y., Aytürk, N., Kılıç, Ü., Ozansoy, M. ve Kılıç, E. (2017). Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury. Neural Regeneration Research, 12(5), 761-764. https://dx.doi.org/10.4103/1673-5374.206646
Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.