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dc.contributor.authorKeskin, İlknur
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:54Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:54Z
dc.date.issued2017en_US
dc.identifier.citationKeskin, İ., Günal, M. Y., Aytürk, N., Kılıç, Ü., Ozansoy, M. ve Kılıç, E. (2017). Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury. Neural Regeneration Research, 12(5), 761-764. https://dx.doi.org/10.4103/1673-5374.206646en_US
dc.identifier.issn1673-5374
dc.identifier.issn1876-7958
dc.identifier.urihttps://dx.doi.org/10.4103/1673-5374.206646
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3487
dc.descriptionWOS: 000403378800018en_US
dc.descriptionPubMed ID: 28616032en_US
dc.description.abstractRecent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.en_US
dc.language.isoengen_US
dc.publisherMedknow Publications & Media Pvt Ltd.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/*
dc.subjectNerve Regenerationen_US
dc.subjectNeuroprotectionen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectCold-Induced Brain Injuryen_US
dc.subjectEnoxaparinen_US
dc.subjectAnti-Oxidativeen_US
dc.subjectApoptosisen_US
dc.subjectNeural Regenerationen_US
dc.titleDose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injuryen_US
dc.typearticleen_US
dc.relation.ispartofNeural Regeneration Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-7059-1884en_US
dc.authorid0000-0001-7702-2441en_US
dc.authorid0000-0002-6895-8560en_US
dc.authorid0000-0002-1079-8832en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume12en_US
dc.identifier.issue5en_US
dc.identifier.startpage761en_US
dc.identifier.endpage764en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4103/1673-5374.206646en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ3en_US


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