dc.contributor.author | Keskin, İlknur | |
dc.contributor.author | Günal, Mehmet Yalçın | |
dc.contributor.author | Aytürk, Nilüfer | |
dc.contributor.author | Kılıç, Ülkan | |
dc.contributor.author | Ozansoy, Mehmet | |
dc.contributor.author | Kılıç, Ertuğrul | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:01:54Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:01:54Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Keskin, İ., Günal, M. Y., Aytürk, N., Kılıç, Ü., Ozansoy, M. ve Kılıç, E. (2017). Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury. Neural Regeneration Research, 12(5), 761-764. https://dx.doi.org/10.4103/1673-5374.206646 | en_US |
dc.identifier.issn | 1673-5374 | |
dc.identifier.issn | 1876-7958 | |
dc.identifier.uri | https://dx.doi.org/10.4103/1673-5374.206646 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3487 | |
dc.description | WOS: 000403378800018 | en_US |
dc.description | PubMed ID: 28616032 | en_US |
dc.description.abstract | Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Medknow Publications & Media Pvt Ltd. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 Unported | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/3.0/ | * |
dc.subject | Nerve Regeneration | en_US |
dc.subject | Neuroprotection | en_US |
dc.subject | Traumatic Brain Injury | en_US |
dc.subject | Cold-Induced Brain Injury | en_US |
dc.subject | Enoxaparin | en_US |
dc.subject | Anti-Oxidative | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Neural Regeneration | en_US |
dc.title | Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Neural Regeneration Research | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-7059-1884 | en_US |
dc.authorid | 0000-0001-7702-2441 | en_US |
dc.authorid | 0000-0002-6895-8560 | en_US |
dc.authorid | 0000-0002-1079-8832 | en_US |
dc.authorid | 0000-0001-6494-8923 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 761 | en_US |
dc.identifier.endpage | 764 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4103/1673-5374.206646 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q3 | en_US |