• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace@Medipol
  • Fakülteler
  • Uluslararası Tıp Fakültesi
  • Makale Koleksiyonu
  • View Item
  •   DSpace@Medipol
  • Fakülteler
  • Uluslararası Tıp Fakültesi
  • Makale Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Design of dense brush conformation bearing gold nanoparticles as theranostic agent for cancer

Thumbnail

View/Open

Tam Metin / Full Text (1.754Mb)

Access

info:eu-repo/semantics/embargoedAccess

Date

2019

Author

Verimli, Nihan
Demiral, Ayşegül
Yılmaz, Hülya
Çulha, Mustafa
Erdem, Sultan Sibel

Metadata

Show full item record

Citation

Verimli, N., Demiral, A., Yılmaz, A., Çulha, M. ve Erdem, S. S. (2019). Design of dense brush conformation bearing gold nanoparticles as theranostic agent for cancer. Applied Biochemistry and Biotechnology, 189(3), 709-728. https://doi.org/10.1007/s12010-019-03151-6

Abstract

Dense brush conformation–bearing theranostic agents are emerging as drug delivery systems due to their higher ability to escape from reticuloendothelial system uptake which prolongs their in vivo circulation time. With the aim of developing dual therapy agent, 13-nm gold nanoparticles’ (AuNPs) surfaces were coated with different amounts of polyethylene glycol (PEG) (SH-PEG-NH2) to obtain dense brush conformation–bearing theranostic agents. Among the 14 different theranostic agent candidates prepared, the one hosting 1819 PEG per particle was selected as the most promising theranostic agent candidate based on structural conformation, stability, size, zeta potential, hemocompatibility, cell inhibition, and cell death pathway towards MCF-7 cell line. To test drug delivery efficiency of the developed PEGylated AuNP and to improve efficacy of the treatment, apoptotic peptide (AP) was covalently conjugated to NH2 terminus of the PEG in various ratios to yield AuNP-AP conjugate. Among the prepared conjugates, the one having 1 nmol of peptide per milliliter of AuNP yielded the most promising results based on the same criteria as employed for PEGylated AuNPs. Besides, incorporation of AP to AuNP returned in superior efficacy of AP since it was possible to achieve 50% cell death with 1000 times less amount of AP alone.

WoS Q Kategorisi

Q3

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q2

Source

Applied Biochemistry and Biotechnology

Volume

189

Issue

3

URI

https://doi.org/10.1007/s12010-019-03151-6.
https://hdl.handle.net/20.500.12511/4932

Collections

  • Makale Koleksiyonu [276]
  • Makale Koleksiyonu [69]
  • Makale Koleksiyonu [289]
  • PubMed İndeksli Yayınlar Koleksiyonu [3758]
  • Scopus İndeksli Yayınlar Koleksiyonu [5797]
  • WoS İndeksli Yayınlar Koleksiyonu [5977]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Guide | Contact |

DSpace@Medipol

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValueScopus Q ValuePublisherAccess TypeThis CollectionBy Issue DateAuthorsInstitution AuthorORCIDTitlesSubjectsTypeLanguageDepartmentCategoryWoS Q ValueScopus Q ValuePublisherAccess Type

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Guide || Library || İstanbul Medipol University || OAI-PMH ||

Kütüphane ve Dokümantasyon Daire Başkanlığı, İstabul, Turkey
If you find any errors in content, please contact: [email protected]

Creative Commons License
DSpace@Medipol by İstanbul Medipol University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Medipol:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.