Development of a chemogenetic approach to manipulate intracellular pH
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info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/Tarih
2023Yazar
Zaki, Asal GhaffariMiri, Seyed Mohammad
Çimen, Şeyma
Akgül Çağlar, Tuba
Yiğit, Esra Nur
Aydın, Mehmet S.
Öztürk, Gürkan
Eroğlu, Emrah
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Zaki, A. G., Miri, S. M., Çimen, Ş., Akgül Çağlar, T., Yiğit, E. N., Aydın, M. Ş. ... Eroğlu, E. (2023). Development of a chemogenetic approach to manipulate intracellular pH. Journal of the American Chemical Society, 145(22), 11899-11902. https://dx.doi.org/10.1021/jacs.3c00703Özet
Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. The genetically encoded biosensor SypHer3s showed that pH-Controleffectively acidifies cytosolic, mitochondrial, and nuclear pH exclusivelyin the presence of beta-chloro-d-alanine in living cellsin a concentration-dependent manner. The pH-Control approach is promisingfor investigating the ultralocal pH imbalance associated with manydiseases.
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Journal of the American Chemical SocietyCilt
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