• PEGylated reduced graphene oxide as nanoplatform for targeted gene and drug delivery 

  Demirel, Erhan; Yüksel Durmaz, Yasemin (Elsevier Ltd, 2023)

  Combination therapies involving anticancer drugs and gene therapy agents have become a potential treatment for different cancer types reducing the side effects of anticancer drugs while enhancing their effectiveness. Here, ...

• Oxide glass formers extending persistent luminescence in Eu and Dy co-doped strontium aluminates 

  Coşgun Ergene, Arzu; Khabbaz Abkenar, Sirous; Şenol Güngör, Ayça; Günay, Ece; Kurt, Hasan; Topçu, Gökhan; Ow-Yang, Cleva W. (Elsevier B.V., 2023)

  Recent work has shown that the incorporation of electrically charged, non-bridging oxygen (NBO) species into Eu and Dy co-doped Sr4Al14O25 (S4A7ED) crystal structure, in the form of BØ2O−, induces the clustering of divalent ...

• Identification of PDE10A related proteins via proteomic analysis 

  Beker, Mustafa Çağlar; Yelkenci, Hayriye Ecem; Çağlayan, Berrak; Kılıç, Ertuğrul (İnönü University Faculty of Medicine, 2022)

  Aim: Phosphodiesterase 10A (PDE10A) regulates the expression of secondary messengers of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which control several intracellular signaling pathways. Recently, ...

• Culturing, freezing, processing, and imaging of entire organoids and spheroids while still in a hydrogel 

  Tok, Olgu Enis; Demirel, Gamze; Saatçi, Yusuf; Akbulut, Zeynep; Kayalar, Özgecan; Aktaş, Ranan Gülhan (Journal of Visualized Experiments, 2022)

  Organoids and spheroids, three-dimensional growing structures in cell culture labs, are becoming increasingly recognized as superior models compared to two-dimensional culture models, since they mimic the human body better ...

• Depression affects working memory performance: A Functional Near Infrared Spectroscopy (fNIRS) Study 

  Vural Keleş, Özge; Yıldırım, Erol (Elsevier Ireland Ltd, 2023)

  Depression is a complex disorder that can be caused by psychosocial and biological conditions, and it not only affects to emotional life, but also cognitive functions, specifically the executive functions, attention, ...

• Seminal trace elements and their relationship with sperm parameters 

  Karabulut, Seda; Korkmaz, Serol; Güneş, Ertuğrul; Kabil, Erol; Keskin, İlknur; Usta, Melek; Omurtag, Gülden Zehra (Wiley, 2022)

  Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due ...

• Dual action of exosomes derived from in vitro A beta toxicity model: The role of age for pathological response 

  Beker, Merve; Günay, Necmeddin; Sarıkamış, Bahar; Kalkan Çakmak, Rabia; Erçin, Nilüfer; Altıntaş, Mehmet Özgen; Altunay, Serdar; Beker, Mustafa Çağlar; Sarı Ak, Duygu; Kılıç, Ülkan (Elsevier Ireland Ltd, 2023)

  Exosomes released from different cell types of the central nervous system play an essential role in the patho-genesis of Alzheimer's disease (AD). In this study, we aimed to create an animal model by injecting exosomes ...

• Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish 

  Yurtsever, İlknur; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)

  Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ...

• Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study 

  Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B.; del Percio, Claudio (Oxford University Press Inc, 2022)

  In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors ...

• Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS 

  İlter, Metehan; Kaşmer, Ramazan; Jalalypour, Farzaneh; Atılgan, Canan; Topçu, Ozan; Karakaş, Nihal; Şensoy, Özge (NLM (Medline), 2022)

  Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ...

• Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke 

  Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Altunay, Serdar; Özbay, Elif; Ateş, Nilay; Keleştemur, Taha; Çağlayan, Berrak; Kılıç, Ülkan; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2022)

  Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ...

• Ozone therapy restores immune dysfunction in refractory idiopathic granulomatous mastitis as a novel potential therapeutic approach 

  Cabıoğlu, Neslihan; Çetin Aktaş, Esin; Emiroğlu, Selman; Tükenmez, Mustafa; Özkurt, Enver; Müslümanoğlu, Mahmut; İğci, Abdullah; Özmen, Vahit; Deniz, Günnur; Dinççağ, Ahmet Sait; Güven, Yusuf İzzettin (Wiley, 2023)

  Immunological dysfunction has been suggested to play a major role in the pathogenesis of idiopathic granulomatous mastitis (IGM). We recently showed that ozone therapy was effective in patients with steroid-resistant IGM. ...

• Arctium minus metanol ekstresinin çeşitli kanser hücre hatları üzerinde sitotoksik etkileri 

  Sayın Şakul, Ayşe Arzu; Yozgat Byrne, Yasemin; Karadağ, Ayşe Esra; Altınalan, Ebrar; Çimen, Şeyma; Okur, Mehmet Evren (Ankara Üniversitesi, 2022)

  Amaç: Bu çalışmada Arctium minus (Hill) Bernh. ssp. minus’un toprak üstü kısımlarından elde edilen metanol ekstresinin kanser hücre hatları üzerindeki sitotoksik etkilerinin değerlendirilmesi amaçlanmıştır. Gereç ve ...

• Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2 

  Doğan, Kübra; Erol, Ebru; Orhan, Müge Didem; Değirmenci, Zehra; Kan, Tuğçe; Güngör, Ayşen; Yaşa, Belkıs; Avşar, Timuçin; Çetin, Yüksel; Durdağı, Serdar; Güzel, Mustafa (Wiley, 2022)

  Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment ...

• A new strategy for direct solution electrospinning of phosphorylated poly(vinyl chloride)/polyethyleneimine blend in alcohol media 

  Altınkök, Çağatay; Sağdıç, Gökhan; Dağlar, Özgün; Ercan Ayra, Merve; Yüksel Durmaz, Yasemin; Durmaz, Hakan; Açık, Gökhan (Elsevier Ltd, 2023)

  Phosphorylated poly(vinyl chloride) (PPVC)/polyethyleneimine (PEI)-based nanofibers were produced via electrospinning in their blended solutions for the first time. For this purpose, PVC was partially converted into PVC-N3 ...

• Extracellular vesicles derived from neural progenitor cells--a preclinical evaluation for stroke treatment in mice (vol 12, pg 185, 2021) 

  Zheng, Xuan; Zhang, Lin; Kuang, Yaoyun; Venkataramani, Vivek; Jin, Fengyan; Hein, Katharina; Zafeiriou, Maria Patapia; Lenz, Christof; Moebius, Wiebke; Kılıç, Ertuğrul; Hermann, Dirk Matthias; Weber, Martin S.; Urlaub, Henning; Zimmermann, Wolfram Hubertus; BäHR, Mathias; Doeppner, Thorsten Roland (Springer, 2022)

  In the version of this article initially published, there were errors on pages 5 and 6.

• Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia? 

  Güntekin, Bahar; Aktürk, Tuba; Arakaki, Xianghong; Bonanni, Laura; Del Percio, Claudio; Edelmayer, Rebecca; Farina, Francesca; Ferri, Raffaele; Hanoğlu, Lütfü; Kumar, Sanjeev; Lizio, Roberta; Lopez, Susanna; Murphy, Brian; Noce, Giuseppe; Randall, Fiona; Sack, Alexander T.; Stocchi, Fabrizio; Yener, Görsev; Yıldırım, Ebru; Babiloni, Claudio (John Wiley and Sons Inc, 2022)

  Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology ...

• Dual action of exosomes derived from in vitro Aβ toxicity model: The role of age for pathological response 

  Beker, Merve; Günay, Necmeddin; Sarıkamış, Bahar; Kalkan Çakmak, Rabia; Erçin, Nilüfer; Altıntaş, Mehmet Özgen; Altunay, Serdar; Beker, Mustafa Çağlar; Sarı Ak, Duygu; Kılıç, Ülkan (Elsevier Ireland Ltd, 2023)

  Exosomes released from different cell types of the central nervous system play an essential role in the pathogenesis of Alzheimer's disease (AD). In this study, we aimed to create an animal model by injecting exosomes that ...

• A new innovative method for model efficiency performance 

  Şen, Zekai; Şişman, Eyüp; Kızılöz, Burak (IWA Publishing, 2022)

  In every aspect of scientific research, model predictions need calibration and validation as their representativity of the record measurement. In the literature, there are a myriad of formulations, empirical expressions, ...

• A fast transform for brain connectivity difference evaluation 

  Zanin, Massimiliano; Ivanoska, Ilinka; Güntekin, Bahar; Yener, Görsev; Loncar-Turukalo, Tatjana; Jakovljevic, Niksa; Sveljo, Olivera; Papo, David (Humana Press Inc, 2022)

  Anatomical and dynamical connectivity are essential to healthy brain function. However, quantifying variations in connectivity across conditions or between patient populations and appraising their functional significance ...

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