• Gelir getirmeyen su oranı tahmin modelleri 

  Kızılöz, Burak; Şişman, Eyüp (Niğde Ömer Halisdemir Üniversitesi, 2021)

  Bu araştırmada Gelir Getirmeyen Su Oranı (GGSO) tahminleri, Kocaeli’nin en fazla su kaybı yaşanan altı ilçesinin 2018 ve2019 yıllarına ait iki yıllık verisi dikkate alınarak ve tüketilen su miktarı, şebeke uzunluğu, servis ...

• Effects of cichorium intybus on GABA(A) receptors and apoptosis in pentylenetetrazole-induced kindling in rats 

  Ergül Erkeç, Özlem; Meral, İsmail; Kara, Mehmet; Eşrefoğlu, Mukaddes; Tok, Olgu Enis; Üstünova, Savaş; Armağan, Metin (Kare Publishing, 2021)

  Objectives: This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABA(A) receptor density in the brains of rats in pentyleneterazole induced kindling. Methods: The rats were divided ...

• Inhibition of fatty acid synthesis aggravates brain injury, reduces blood-brain barrier integrity and impairs neurological recovery in a murine stroke model 

  Janssen, Lisa; Ai, Xiaoyu; Zheng, Xuan; Wei, Wei; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Wang, Ya-chao; Hermann, Dirk M.; Venkataramani, Vivek; Baehr, Mathias; Doeppner, Thorsten R. (Frontiers Media SA, 2021)

  Inhibition of fatty acid synthesis (FAS) stimulates tumor cell death and reduces angiogenesis. When SH-SY5Y cells or primary neurons are exposed to hypoxia only, inhibition of FAS yields significantly enhanced cell injury. ...

• Dual function of HSP70 in cytoprotection of tumor cells and generation of immunosuppressive tumor microenvironment 

  Korkaya, Hasan; Köksalar Alkan, Fulya; Ece Arslan, Z.; Altıntaş, Esra; Piranlıoğlu, Raziye; Lee, Eunmi; Wicha, Max S. (American Association for Cancer Research, 2021)

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• Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment 

  Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lütfü; Yener, Görsev; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; del Percio, Claudio (IOS Press, 2021)

  Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha ...

• Microwave-promoted continuous flow systems in nanoparticle synthesis-A perspective 

  Saleem, Qandeel; Torabfam, Milad; Fidan, Tuçe; Kurt, Hasan; Yüce, Meral; Clarke, Nigel; Bayazıt, Mustafa Kemal (American Chemical Society, 2021)

  Microwave-promoted continuous flow systems have emerged as a game-changer in nanoparticle synthesis. Owing to the excellent compatibility between fast, sustainable microwave heating and one-step, efficient flow chemistry, ...

• Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder 

  Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)

  Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...

• Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro 

  Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)

  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ...

• A rational design of multi-functional nanoplatform: Fluorescent-based “off-on” theranostic gold nanoparticles modified with D-α-Tocopherol succinate 

  Demiral, Ayşegül; Verimli, Nihan; Goralı, İrem; Yılmaz, Hülya; Çulha, Mustafa; Erdem, Sultan Sibel (Elsevier B.V., 2021)

  It is crucial to develop nanocarrier systems to detect and treat drug-resistant micro tumors to prevent recurrence and/or metastasis of cancer. Due to their exceptional features such as biocompatibility, easy surface ...

• Prognostic significance of SERPINB1 expression in gliomas 

  Uludağ, D.; Karaoğlan, B. S.; Genç, B.; Tahta, A.; Mohr, T.; Çakır, A.; Mayliba, H. B.; Karakaş, N. (Wiley, 2021)

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• Innovative flow risk assessment with climate change perspective in Yesilirmak Basın (vol 29, pg 514, 2020) 

  Serancam, Uğur; Dabanlı, İsmail (Parlar Scientific Publications, 2021)

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• The effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution 

  Özçiçek, İlyas; Ayşit, Neşe; Çakıcı, Çağrı; Aydeğer, Asel (Elsevier B.V., 2021)

  Gold nanoparticles are emerging as promising nanomaterials to create nanoscale therapeutic delivery systems. The aim of the study was to synthesis of highly monodisperse and stable gold nanoparticles functionalized with ...

• Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method 

  Avnioğlu, Seda; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (Lippincott Williams & Wilkins, 2021)

  Background Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are ...

• Effects of gallic acid on endometrial cancer cells in two and three dimensional cell culture models 

  Bülbül, Muhammet Volkan; Karabulut, Seda; Kalender, Mervenur; Keskin, İlknur (Asian Pacific Organization for Cancer Prevention, 2021)

  Background and Aim: Cell culture studies are an indispensable tools used to understand basic physiological, biophysical and biomolecular mechanisms. Although traditional two-dimensional (2D) cell culture models are more ...

• IL13 fused pseudomonas exotoxin targets various cancers in vitro 

  Uludağ, Damla; Karakaş, Nihal (International Institute of Anticancer Research, 2021)

  Background/Aim: Pseudomonas exotoxin (PE) is one of the most widely used toxins in the construction of therapeutic fusion proteins in pre-clinical studies followed by phase trials. In principle, PE acts by blocking protein ...

• Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation 

  Karakaş, Nihal; Kılıç, Ülkan (International Institute of Anticancer Research, 2021)

  Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ...

• Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies 

  Şener, Nesrin; Özkınalı, Sevil; Çelik Altunoğlu, Yasemin; Yerlikaya, Şerife; Gökçe, Halil; Zurnacı, Merve; Gür, Mahmut; Baloğlu, Mehmet Cengiz; Şener, İzzet (Elsevier, 2021)

  New pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the ...

• Gender-specific modeling of growth profiles in pre-school-age children 

  Koçak, Mehmet; Wolde, Alemayehu; Tylavsky, Frances A. (Türkiye Klinikleri, 2020)

  Objective: In pediatric clinical trials and cohort stu ies, actual height, weight and head circumference of children at a specific age may be required for certain developmental assessments such as energy expenditure. This ...

• Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity by NF-kappa B (Nuclear Factor-kappa B)-dependent regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in stroke mice 

  Zhang, Lin; Graf, Irina; Kuang, Yaoyun; Zheng, Xuan; Haupt, Matteo; Majid, Arshad; Kılıç, Ertuğrul; Hermann, Dirk M.; Psychogios, Marios-Nikos; Weber, Martin S.; Ochs, Jasmin; Baehr, Mathias; Doeppner, Thorsten R. (Lippincott Williams & Wilkins, 2021)

  Objective: Extracellular vesicles (EVs) derived from neural progenitor cells enhance poststroke neurological recovery, albeit the underlying mechanisms remain elusive. Since previous research described an enhanced poststroke ...

• Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress 

  Velioğlu, Halil Aziz; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Toprak, Güven; Güler, Eray Metin; Bektay, Muhammed Yunus; Mutlu Burnaz, Özlem; Yuluğ, Burak (Academic Press Inc., 2021)

  Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ...

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