• Quest for quality in translational stroke research––a new dawn for neuroprotection? 

  Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (Multidisciplinary Digital Publishing Institute, 2022)

  Despite tremendous progress in modern‐day stroke therapy, ischemic stroke remains a disease associated with a high socioeconomic burden in industrialized countries. In light of demo-graphic change, these health care costs ...

• Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels 

  Sevimli, Gülşah; Smith, Matthew J.; Akgül Çağlar, Tuba; Bilir, Şükriye; Seçilmiş, Melike; Altun, Hamza Y.; Yiğit, Esra N.; Yang, Fan; Keeley, Thomas P.; Malli, Roland; Öztürk, Gürkan; Mann, Giovanni E.; Eroğlu, Emrah (Elsevier B.V., 2022)

  Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation ...

• The rhythmicity of life: A review of the circadian clocks 

  Açıkgöz, Eda; Karahüseyinoğlu, Serçin; Ayla, Şule; Öktem, Gülperi (Begell House Inc., 2021)

  Physiology of the mammalian body has been adapted to diurnal cycles of around 24 h, an evolutionary situation that affects a wide spectrum of biological events including sleep-to-wake transitions, feeding/fasting, body ...

• Revealing nervous and cardiac system interactions by iPSC-Based platforms 

  Mutlu Burnaz, Özlem; Çağavi, Esra (Elsevier, 2022)

  Cardiac function is regulated by the autonomic nervous system. In exchange, the sensorial information from the heart is relayed to the brain via sensory neurons as a crucial modulatory feedback mechanism. Cardiovascular ...

• Comparison of 3 cell-free matrix scaffolds used to treat osteochondral lesions in a rabbit model 

  Demir, Ahder İrem; Pulatkan, Anıl; Uçan, Vahdet; Yılmaz, Bengi; Tahmasebifar, Aydın; Tok, Olgu Enis; Tuncay, İbrahim; Elmalı, Nurzat; Öztürk, Burak Yağmur; Uzer, Gökçer (SAGE Publications Inc., 2022)

  Background: Various cell-free scaffolds are already in use for the treatment of osteochondral defects (OCDs); however, a gold standard material has not yet been defined. Purpose: This study compared the macroscopic, ...

• Temperature and pH-dependent behaviors of mAb drugs: A case study for trastuzumab 

  Sert, Fatma; Hız, Defne; Gülmez, Mert; Cankurtaran, Selen Ezgi; Kayalan, Cemre Irmak; Kurt, Hasan; Yüce, Meral (MDPI, 2022)

  The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. ...

• Tilia tomentosa moench çiçeklerinin uçucu bileşenlerinin ve çeşitli in vitro biyolojik aktivitelerinin incelenmesi 

  Karakaş, Nihal; Okur, Mehmet Evren; Öztunç, Nurşah; Karadağ, Ayşe Esra; Kültür, Şükran; Demirci, Betül (2019)

  Amaç: Tilia tomentosa Moench. (Malvaceae) bitkisinin çiçeklerinden elde edilen n-hekzan ekstresinin uçucu bileşenleri, toplam fenolik madde miktarı, in vitro antioksidan, antimikrobiyal ve hücre canlılığı aktivitelerinin ...

• The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy 

  Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)

  Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ...

• Protein kinaz C aktivatörü PMA’nın TRPV1 kanalları üzerindeki etkileri 

  Özgül, Cemil (Hacettepe Üniversitesi, 2015)

  TRP alt ailesinin bir üyesi olarak bilinen TRPV1 kanalları non-selektif katyon kanallarıdır. Bu kanalların en fazla bulunduğu dokular; arka kök gangliyon nöronları, vagal nöronlar ve trigeminal gangliyon nöronlarıdır. TRPV1 ...

• Investigation of the effect of adalimumab on experimental brain injury in mice 

  Günal, Mehmet Yalçın; Çankaya, Seyda; Tönük, Şükrü Burak; Özdemir, Ekrem Musa; Sayın Şakul, Ayşe Arzu (2019)

  Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect". Methods: ...

• Evaluation of in situ gel containing pycnogenol for cutaneous wound healing 

  Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)

  Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ...

• Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer 

  Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)

  Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...

• Predicting a water infrastructure leakage index via machine learning 

  Kızılöz, Burak; Şişman, Eyüp; Oruç, Halil Nurullah (Elsevier Ltd, 2022)

  In this study, the infrastructure leakage index (ILI) indicator that is preferred frequently by the water utilities with sufficient data to determine the performances of water distribution systems is modeled for the first ...

• Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors 

  Ghaffari Zaki, Asal; Erdoğan, Yusuf Ceyhun; Akgül Çağlar, Tuba; Eroğlu, Emrah (Portland Press Ltd, 2022)

  Chemogenetic tools are recombinant enzymes that can be targeted to specific organelles and tissues. The provision or removal of the enzyme substrate permits control of its biochemical activities. Yeast-derived enzyme D-amino ...

• Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy 

  Beker, Mustafa Çağlar; Beker, Merve; Çağlayan, Ahmet Burak; Bolat, Busenur; Kılıç, Ülkan; Köse, Gamze; Kılıç, Ertuğrul (Turkey Clinics, 2022)

  Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ...

• The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians 

  Söylemez, Esra; Özçağlı, Eren; Korkmaz, Serol; Tok, Olgu Enis; Aydın, Mehmet Şerif; Omurtag, Gülden Zehra (SAGE Publications Ltd, 2022)

  Ionizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions ...

• Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates 

  Hanoğlu, Lütfü; Toplutaş, Eren; Sarıçaoğlu, Mevhibe; Velioğlu, Halil Aziz; Yıldız, Sultan; Yuluğ, Burak (Frontiers Media SA, 2022)

  Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ...

• Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines 

  Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)

  Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ...

• Investigating the molecular and functional interaction between human macrophages and HiPSC-derived cardiomyocytes by an in vitro arrhythmia model 

  Koç, Arzuhan; Akdeniz, Celal; Çağavi, Esra (Wiley, 2021)

  ...

• Mesenchymal stem cell-based COVID-19 therapy: Bioengineering perspectives 

  Karakaş, Nihal; Üçüncüoğlu, Süleyman; Uludağ, Damla; Karaoğlan, Birnur Sinem; Shah, Khalid; Öztürk, Gürkan (MDPI, 2022)

  The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) are currently utilized in clinics for pulmonary inflammatory ...

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