• Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice 

  Beker, Mustafa Çağlar; Pençe, Mahmud Esad; Yağmur, Sümeyya; Çağlayan, Berrak; Çağlayan, Aysun; Kılıç, Ülkan; Yelkenci, Hayriye Ecem; Altıntaş, Mehmet Özgen; Çağlayan, Ahmet Burak; Doeppner, Thorsten Roland; Hermann, Dirk M.; Kılıç, Ertuğrul (Academic Press Inc., 2022)

  The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ...

• Synthesis of novel oxadiazole derivatives and their cytotoxic activity against various cancer cell lines 

  Sucu, Bilgesu Onur; Koç, Elif Beyza (TUBITAK, 2022)

  Caffeic acid (CA), ferulic acid (FA) and caffeic acid phenethyl ester (CAPE) have a broad anticancer effect on various cell lines. In this study, nine ferulic and caffeic acid-based 1,2,4 and 1,3,4 oxadiazole molecular ...

• Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism 

  Doeppner, Thorsten R.; Coman, Cristin; Burdusel, Daiana; Ancuta, Diana Larisa; Brockmeier, Ulf; Pirici, Daniel Nicolae; Kuang Yaoyun; Hermann, Dirk M.; Popa Wagner, Aurel (Impact Journals LLC, 2022)

  Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ...

• First case with RANBP2 biallelic mutation and severe acute necrotizing encephalopathy phenotype 

  Ayaz, Akif; Doğru, Zeynep; Kılıç, Betül; Süzek, Barış Ethem (Elsevier B.V., 2022)

  Familial acute necrotizing encephalopathy (ANE) is a rapidly progressive encephalopathy that can occur after common viral infections at different stages of life. The clinical findings of 2 siblings diagnosed with ANE were ...

• Enhancing memory capacity by experimentally slowing theta frequency oscillations using combined EEG-tACS 

  Aktürk, Tuba; de Graaf, Tom A.; Güntekin, Bahar; Hanoğlu, Lütfü; Sack, Alexander T. (Nature Portfolio, 2022)

  he coupling of gamma oscillation (similar to 40+ Hz) amplitude to the phase of ongoing theta (similar to 6 Hz) oscillations has been proposed to be directly relevant for memory performance. Current theories suggest that ...

• Replating protocol for human induced pluripotent stem cell–derived cardiomyocytes 

  Koç, Arzuhan; Çağavi, Esra (Humana Press Inc., 2022)

  Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational cardiac research. Obtaining hiPSC-CM culture as a single-cell, monolayer or three-dimensional ...

• Experimental and computational investigation of clustering behavior of cyclodextrin-perfluorocarbon inclusion complexes as effective histotripsy agents 

  Kaymaz, Betül; Mustafa, Waleed; Hall, Sarah; Vlaisavljevich, Eli; Şensoy, Özge; Yüksel Durmaz, Yasemin (American Chemical Society, 2022)

  Recently developed nanocones (NCs), which are inclusion complexes that are made up of cyclodextrins (CDs) and perfluorocarbons (PFCs), have shown promising results in nanoparticle-mediated histotripsy (NMH) applications ...

• Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach 

  Kazcı, Yusuf Enes; Şahoğlu Göktaş, Sevilay; Aydın, Mehmet Şerif; Karadoğan, Behnaz; Nebol, Aylin; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Elsevier B.V., 2022)

  Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional ...

• Porous, columnar shaped iron rich oxide synthesis for lithium-ion batteries from metallurgical grade, domestic, high carbon ferro-chromium alloys 

  Gülcan, Mehmet Feryat; Karahan, Billur Deniz; Gürmen, Sebahattin (Elsevier Ltd, 2022)

  With this article, first time in the open literature, the synthesis, and the characterization of an anode material from a domestic, intermediate product (i.e. ferrochromium alloy) have been carried out. The presented ...

• Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke 

  Hermann, Dirk M.; Xin, Wenqiang; Baehr, Mathias; Giebel, Bernd; Doeppner, Thorsten R. (Ivyspring International Publisher, 2022)

  Hypoxia is a central pathophysiological component in cancer, myocardial infarction and ischemic stroke, which represent the most common medical conditions resulting in long-term disability and death. Recent evidence suggests ...

• Comparison of S gene mutations in patients with occult and chronic hepatitis B virus infection 

  Çakal, Bülent; Çavuş, Bilger; Atasoy, Alp; Altunok, Damla; Poda, Mehveş; Bulakçı, Mesut; Gülluoğlu, Mine; Demirci, Mehmet; Türker Şener, Leyla; Arslan, Aslı Berru; Arıkan, Muzaffer; Akyüz, Filiz (Elsevier B.V., 2022)

  Background and aim: This study aimed to detect mutations in the HBV S gene and evaluate their relationship to occult hepatitis B virus (HBV) infection (OBI). Methods: The study included 32 patients with negative serum HBsAg ...

• Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels (vol 53, 102319, 2022) 

  Sevimli, Gülşah; Smith, Matthew J.; Akgül Çağlar, Tuba; Bilir, Şükriye; Seçilmiş, Melike; Altun, Hamza Y.; Yiğit, Esra N.; Yang, Fan; Keeley, Thomas P.; Malli, Roland; Öztürk, Gürkan; Mann, Giovanni E.; Eroğlu, Emrah (Elsevier, 2022)

  The authors regret that the cited reference list in the online PDF of this article contains a duplicate reference (Ref 34 and incomplete Ref 56). Ref 56 should read as follows.

• An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine 

  Başpınar Küçük, Hatice; Alhonaish, Anoud; Yıldız, Tülay; Güzel, Mustafa (Wiley-VCH Verlag, 2022)

  An oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o was employed to synthesize new 2,5-disubstituted 1,3,4-oxadiazole compounds 4 a-d, 4 f-i, 4 k-n. This method involves oxidative cyclization of ...

• An integrated top-stage incubator and lens free holographic imaging system for culture monitoring applications 

  Özbilgin, Zeynep; Akşit, Sevdenur; Toy, Muhammed Fatih (SPIE, 2022)

  Lens free inline holographic microscopy was shown to be a potent approach for many applications relying on cellular imaging. Applications requiring a large field of view at moderate resolution are the ones that are most ...

• Maskless lithography with holographic feedback for the fabrication of optical elements 

  Gürcan, Tolga; Toy, Muhammed Fatih (SPIE, 2022)

  Photolithography has become a powerful tool in the fabrication of micro-optical elements following the advancements in grayscale approaches. However, hitting tight design tolerance goals require precise control of all ...

• Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells 

  Uludağ, Damla; Bay, Sadık; Onur Sucu, Bilgesu; Şavluğ İpek, Özgecan; Mohr, Thomas; Güzel, Mustafa; Karakaş, Nihal (Frontiers Media S.A., 2022)

  Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ...

• Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease 

  Yener, Görsev; Hünerli Gündüz, Duygu; Yıldırım, Ebru; Aktürk, Tuba; Başar Eroğlu, Canan; Bonanni, Laura; Del Percio, Claudio; Farina, Francesca; Ferri, Raffaele; Güntekin, Bahar; Hajós, Mihály; Ibáñez, Agustín; Jiang, Yang; Lizio, Roberta; Lopez, Susanna; Noce, Giuseppe; Parra, Mario A.; Randall, Fiona; Stocchi, Fabrizio; Babiloni, Claudio (Elsevier B.V., 2022)

  Alzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta ...

• The preamble to the free radical biology and medicine virtual special issue on “Targeting genetic biosensors to intracellular signaling pathways” 

  Eroğlu, Emrah; Graier, Wolfgang F.; Malli, Roland (Elsevier Inc., 2022)

  Studying biological signaling pathways is key to understanding the various processes within a cell. The science of biological redox regulation is a rapidly growing research area with implications for various disciplines, ...

• Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis 

  Kayasandık, Cihan Bilge; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (Frontiers Media SA, 2022)

  Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ...

• Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial 

  Hajebrahimi, Farzin; Velioğlu, Halil Aziz; Bayraktaroğlu, Zübeyir; Helvacı Yılmaz, Nesrin; Hanoğlu, Lütfü (Nature Research, 2022)

  There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients ...

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