• The rhythmicity of life: A review of the circadian clocks 

  Açıkgöz, Eda; Karahüseyinoğlu, Serçin; Ayla, Şule; Öktem, Gülperi (Begell House Inc., 2021)

  Physiology of the mammalian body has been adapted to diurnal cycles of around 24 h, an evolutionary situation that affects a wide spectrum of biological events including sleep-to-wake transitions, feeding/fasting, body ...

• Revealing nervous and cardiac system interactions by iPSC-Based platforms 

  Mutlu Burnaz, Özlem; Çağavi, Esra (Elsevier, 2022)

  Cardiac function is regulated by the autonomic nervous system. In exchange, the sensorial information from the heart is relayed to the brain via sensory neurons as a crucial modulatory feedback mechanism. Cardiovascular ...

• Comparison of 3 cell-free matrix scaffolds used to treat osteochondral lesions in a rabbit model 

  Demir, Ahder İrem; Pulatkan, Anıl; Uçan, Vahdet; Yılmaz, Bengi; Tahmasebifar, Aydın; Tok, Olgu Enis; Tuncay, İbrahim; Elmalı, Nurzat; Öztürk, Burak Yağmur; Uzer, Gökçer (SAGE Publications Inc., 2022)

  Background: Various cell-free scaffolds are already in use for the treatment of osteochondral defects (OCDs); however, a gold standard material has not yet been defined. Purpose: This study compared the macroscopic, ...

• Tilia tomentosa moench çiçeklerinin uçucu bileşenlerinin ve çeşitli in vitro biyolojik aktivitelerinin incelenmesi 

  Karakaş, Nihal; Okur, Mehmet Evren; Öztunç, Nurşah; Karadağ, Ayşe Esra; Kültür, Şükran; Demirci, Betül (2019)

  Amaç: Tilia tomentosa Moench. (Malvaceae) bitkisinin çiçeklerinden elde edilen n-hekzan ekstresinin uçucu bileşenleri, toplam fenolik madde miktarı, in vitro antioksidan, antimikrobiyal ve hücre canlılığı aktivitelerinin ...

• The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy 

  Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)

  Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ...

• Protein kinaz C aktivatörü PMA’nın TRPV1 kanalları üzerindeki etkileri 

  Özgül, Cemil (Hacettepe Üniversitesi, 2015)

  TRP alt ailesinin bir üyesi olarak bilinen TRPV1 kanalları non-selektif katyon kanallarıdır. Bu kanalların en fazla bulunduğu dokular; arka kök gangliyon nöronları, vagal nöronlar ve trigeminal gangliyon nöronlarıdır. TRPV1 ...

• Investigation of the effect of adalimumab on experimental brain injury in mice 

  Günal, Mehmet Yalçın; Çankaya, Seyda; Tönük, Şükrü Burak; Özdemir, Ekrem Musa; Sayın Şakul, Ayşe Arzu (2019)

  Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect". Methods: ...

• Evaluation of in situ gel containing pycnogenol for cutaneous wound healing 

  Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)

  Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ...

• Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer 

  Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)

  Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...

• Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy 

  Beker, Mustafa Çağlar; Beker, Merve; Çağlayan, Ahmet Burak; Bolat, Busenur; Kılıç, Ülkan; Köse, Gamze; Kılıç, Ertuğrul (Turkey Clinics, 2022)

  Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ...

• The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians 

  Söylemez, Esra; Özçağlı, Eren; Korkmaz, Serol; Tok, Olgu Enis; Aydın, Mehmet Şerif; Omurtag, Gülden Zehra (SAGE Publications Ltd, 2022)

  Ionizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions ...

• Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates 

  Hanoğlu, Lütfü; Toplutaş, Eren; Sarıçaoğlu, Mevhibe; Velioğlu, Halil Aziz; Yıldız, Sultan; Yuluğ, Burak (Frontiers Media SA, 2022)

  Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ...

• Investigating the molecular and functional interaction between human macrophages and HiPSC-derived cardiomyocytes by an in vitro arrhythmia model 

  Koç, Arzuhan; Akdeniz, Celal; Çağavi, Esra (Wiley, 2021)

  ...

• Mesenchymal stem cell-based COVID-19 therapy: Bioengineering perspectives 

  Karakaş, Nihal; Üçüncüoğlu, Süleyman; Uludağ, Damla; Karaoğlan, Birnur Sinem; Shah, Khalid; Öztürk, Gürkan (MDPI, 2022)

  The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) are currently utilized in clinics for pulmonary inflammatory ...

• Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort 

  Yıldırım, Süleyman; Nalbantoğlu, Özkan Ufuk; Bayraktar, Abdulahad; Ercan, Fatma Betül; Gündoğdu, Aycan; Velioğlu, Halil Aziz; Göl, Mehmet Fatih; Ekinci Soylu, Ayten; Koç, Fatma; Aslan Gülpınar, Ezgi; Soğukkanlı Kadak, Kübra; Arıkan, Muzaffer; Mardinoğlu, Adil; Koçak, Mehmet; Köseoğlu, Emel; Hanoğlu, Lütfü (American Society for Microbiology, 2022)

  Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ...

• Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites 

  İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)

  Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ...

• The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model 

  Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakariş, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (University Press, 2022)

  Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative ...

• Kurumda ve kendi evinde yaşayan bir grup yaşlı bireyin beslenme durumlarının değerlendirilmesi 

  Kablan, Şeyma; Metin, Duygu; Arıkan, Ayşe; Garipağaoğlu, Muazzez (2020)

  Yaşlı nüfusun birçok ülkede olduğu gibi ülkemizde de hızla arttığı bilinmektedir. Yaşlılık döneminde, sağlığın iyileştirilmesi ve geliştirilmesinde, yaşam süresinin ve kalitesinin artırılmasında yeterli ve dengeli beslenme ...

• Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells 

  Bülbül, Muhammet Volkan; Özbek, Hanefi; Bahadır Acıkara, Özlem; Özbilgin, Serkan; Ergene Öz, Burçin; Kurtul, Ekin; Keskin, İlknur (Ondokuz Mayıs University, 2018)

  In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis ...

• Axillary microbiota is associated with cognitive impairment in parkinson's disease patients 

  Arıkan, Muzaffer; Yıldız, Zeynep; Kahraman Demir, Tuğçe; Helvacı Yılmaz, Nesrin; Şen, Aysu; Hanoğlu, Lütfü; Yıldırım, Süleyman (American Society for Microbiology, 2022)

  Cognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD), with a substantially negative impact on patient management and outcome. The development and progression of CI exhibits high ...

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