• Effects of cichorium intybus on GABA(A) receptors and apoptosis in pentylenetetrazole-induced kindling in rats 

  Ergül Erkeç, Özlem; Meral, İsmail; Kara, Mehmet; Eşrefoğlu, Mukaddes; Tok, Olgu Enis; Üstünova, Savaş; Armağan, Metin (Kare Publishing, 2021)

  Objectives: This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABA(A) receptor density in the brains of rats in pentyleneterazole induced kindling. Methods: The rats were divided ...

• Inhibition of fatty acid synthesis aggravates brain injury, reduces blood-brain barrier integrity and impairs neurological recovery in a murine stroke model 

  Janssen, Lisa; Ai, Xiaoyu; Zheng, Xuan; Wei, Wei; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Wang, Ya-chao; Hermann, Dirk M.; Venkataramani, Vivek; Baehr, Mathias; Doeppner, Thorsten R. (Frontiers Media SA, 2021)

  Inhibition of fatty acid synthesis (FAS) stimulates tumor cell death and reduces angiogenesis. When SH-SY5Y cells or primary neurons are exposed to hypoxia only, inhibition of FAS yields significantly enhanced cell injury. ...

• Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment 

  Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lütfü; Yener, Görsev; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; del Percio, Claudio (IOS Press, 2021)

  Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha ...

• Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder 

  Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)

  Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...

• Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro 

  Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)

  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ...

• Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method 

  Avnioğlu, Seda; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (Lippincott Williams & Wilkins, 2021)

  Background Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are ...

• Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation 

  Karakaş, Nihal; Kılıç, Ülkan (International Institute of Anticancer Research, 2021)

  Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ...

• Antiproliferative properties and structural analysis of newly synthesized Schiff bases bearing pyrazole derivatives and molecular docking studies 

  Şener, Nesrin; Özkınalı, Sevil; Çelik Altunoğlu, Yasemin; Yerlikaya, Şerife; Gökçe, Halil; Zurnacı, Merve; Gür, Mahmut; Baloğlu, Mehmet Cengiz; Şener, İzzet (Elsevier, 2021)

  New pyrazole Schiffbases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the ...

• Gender-specific modeling of growth profiles in pre-school-age children 

  Koçak, Mehmet; Wolde, Alemayehu; Tylavsky, Frances A. (Türkiye Klinikleri, 2020)

  Objective: In pediatric clinical trials and cohort stu ies, actual height, weight and head circumference of children at a specific age may be required for certain developmental assessments such as energy expenditure. This ...

• Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity by NF-kappa B (Nuclear Factor-kappa B)-dependent regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in stroke mice 

  Zhang, Lin; Graf, Irina; Kuang, Yaoyun; Zheng, Xuan; Haupt, Matteo; Majid, Arshad; Kılıç, Ertuğrul; Hermann, Dirk M.; Psychogios, Marios-Nikos; Weber, Martin S.; Ochs, Jasmin; Baehr, Mathias; Doeppner, Thorsten R. (Lippincott Williams & Wilkins, 2021)

  Objective: Extracellular vesicles (EVs) derived from neural progenitor cells enhance poststroke neurological recovery, albeit the underlying mechanisms remain elusive. Since previous research described an enhanced poststroke ...

• Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress 

  Velioğlu, Halil Aziz; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Toprak, Güven; Güler, Eray Metin; Bektay, Muhammed Yunus; Mutlu Burnaz, Özlem; Yuluğ, Burak (Academic Press Inc., 2021)

  Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ...

• Factors related to follicular oxidative stress in intracytoplasmic sperm injection cycles and its effects on granulosa cells 

  Karabulut, Seda; Korkmaz, Oya; Kutlu, Pelin; Keskin, İlknur (Cambridge University Press, 2021)

  The aim of the present study was to investigate several common conditions that may potentially be correlated with follicular oxidative status during an intracytoplasmic sperm injection (ICSI) cycle and that include the ...

• Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice 

  Kolbaşı, Bircan; Bülbül, Muhammet Volkan; Karabulut, Seda; Erdem Altun, Ceren; Çakıcı, Çağrı; Ülfer, Gözde; Müdok, Tangül; Keskin, İlknur (Elsevier Ltd, 2021)

  Research question: Does chronic stress affect the key proteins and sperm parameters of the blood & ndash;testis barrier (BTB)? Design: C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic ...

• Defining optimal enzyme and matrix combination for replating of human induced pluripotent stem cell-derived cardiomyocytes at different levels of maturity 

  Koç, Arzuhan; Şahoğlu Göktaş, Sevilay; Akgül Çağlar, Tuba; Çağavi, Esra (Elsevier Inc., 2021)

  Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational research. Depending on the maturity of cardiac cultures and the intended applications, ...

• Mesenchymal stem cell applications in polycystic ovary syndrome treatment 

  Bülbül, Muhammet Volkan; Yıldırım, Berna; Kolbaşı, Bircan; Keskin, İlknur (Ondokuz Mayıs Üniversitesi, 2021)

  Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under ...

• Event-related EEG oscillatory responses elicited by dynamic facial expression 

  Aktürk, Tuba; de Graaf, Tom A.; Abra, Yasemin; Şahoğlu Göktaş, Sevilay; Özkan, Dilek; Kula, Aysun; Güntekin, Bahar (BMC, 2021)

  Background Recognition of facial expressions (FEs) plays a crucial role in social interactions. Most studies on FE recognition use static (image) stimuli, even though real-life FEs are dynamic. FE processing is complex and ...

• EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel 

  Babiloni, Claudio C.; Arakaki, Xianghong; Bonanni, Laura; Buján, Ana; Carrillo, María C.; del Percio, Claudio; Edelmayer, Rebecca M.; Egan, Gary; Elahh, Fanny M.; Evans, Alan Charles; Ferri, Raffaele; Frisoni, Glovannl B.; Güntekin, Bahar; Hainsworth, Atticus Henry; Hampel, Harald; Jelić, Vesna; Jeong, Jaeseung; Kim, Doh-kwan; Kramberger, Milica Gregorič; Kumar, Sanjeev; Lizio, Roberta; Nobili, Flavio Mariano; Noce, Giuseppe; Puce, Aina; Ritter, Petra; Smit, Dirk J.A.; Soricelli, Andrea; Teipel, S.; Tucci, Federico (Elsevier Inc., 2021)

  Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A ...

• Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture: A histological and immunohistochemical study 

  Kayalar, Emre; Taş Deynek, Gül; Tok, Olgu Enis; Küçük, Sevim (E H Angle Education Research Foundation, Inc., 2021)

  Objectives: To determine the effects of Salvianolic acid B (Sal B) on new bone formation in the orthopedically expanded premaxillary sutures in rats.Materials and Methods: The sample consisting of Sprague Dawley rats (male, ...

• Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation 

  Haupt, Matteo; Zheng, Xuan; Kuang, Yaoyun; Lieschke, Simone; Janssen, Lisa; Bosche, Bert; Jin, Fengyan; Hein, Katharina; Kılıç, Ertuğrul; Venkataramani, Vivek; Hermann, Dirk M.; Bahr, Mathias; Doeppner, Thorsten R. (Wiley, 2021)

  Lithium is neuroprotective in preclinical stroke models. In addition to that, poststroke neuroregeneration is stimulated upon transplantation of mesenchymal stem cells (MSCs). Preconditioning of MSCs with lithium further ...

• Cardiac immunology: A new era for immune cells in the heart 

  Koç, Arzuhan; Çağavi, Esra (Plenum Press, 2021)

  The immune system is essential for the development and homeostasis of the human body. Our current understanding of the immune system on disease pathogenesis has drastically expanded over the last decade with the definition ...

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