Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)Regenerative and Restorative Medicine Research Centerhttps://hdl.handle.net/20.500.12511/45032024-03-29T15:36:35Z2024-03-29T15:36:35ZThe investigation of inflammation in drug-naive first-episode mania by measuring ferritin, peripheral inflammatory markers, and their ratiosYeşilkaya, Ümit HalukBişgin, Ertuğrulhttps://hdl.handle.net/20.500.12511/124032024-03-28T10:46:13Z2024-01-01T00:00:00ZThe investigation of inflammation in drug-naive first-episode mania by measuring ferritin, peripheral inflammatory markers, and their ratios
Yeşilkaya, Ümit Haluk; Bişgin, Ertuğrul
Objective: Bipolar disorder (BD) is a complex psychiatric disorder with a multifactorial etiology involving both genetic and environmental factors. Increased inflammatory parameters have been shown in previous studies in bipolar disorder. However, it is not known whether ferritin and other inflammatory markers, primarily involved in autoimmune reactions and inflammation, change at the onset of the first episode. We aimed to investigate whether inflammation levels are elevated in the first episode of mania by measuring peripheral inflammatory markers with their ratios and ferritin. Methods: Fifty-six drug-naive individuals experiencing their first episode of mania (FEM) were clinically diagnosed in accordance with DSM-5 criteria. A control cohort (HC) comprising 57 individuals matched with the patients was included in the study. During the evaluation, symptoms were assessed using BPRS (Brief Psychiatric Rating Scale) and YMRS (Young Mania Rating Scale). Blood specimens were obtained from all participants to analyze levels of white blood cells (WBC), neutrophils, monocytes, albumin, ferritin, C-reactive protein (CRP), lymphocytes, and platelets and determine specific protein ratio. Results: Monocyte, Neutrophil-lymphocyte ratio (NLR), Monocyte-lymphocyte ratio (MLR), and neutro-phil–albumin ratio (NAR), values were statistically higher in the patient group than in the control group. A statistically significant positive correlation was found between ferritin values, BPRS, and YMRS scores.It was determined that NLR and NAR ratios predict the severity of the disease. Conclusion: These findings suggest that while inflammation may not be a definitive predictor for BD, it correlates with the disease’s severity.
2024-01-01T00:00:00ZEffects of pinealectomy and melatonin application on Serum Melatonin, Nesfatin-1 and ghrelin levelsSönmez, SaadetMenevşe, EsmaBaltacı, Saltuk BuğraÜnal, ÖmerMoğulkoç, RasimBaltacı, Abdulkerim Kasımhttps://hdl.handle.net/20.500.12511/123712024-03-15T10:49:55Z2023-01-01T00:00:00ZEffects of pinealectomy and melatonin application on Serum Melatonin, Nesfatin-1 and ghrelin levels
Sönmez, Saadet; Menevşe, Esma; Baltacı, Saltuk Buğra; Ünal, Ömer; Moğulkoç, Rasim; Baltacı, Abdulkerim Kasım
Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats.
Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals.
Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01).
Conclusion: The findings of the study draw attention to an important relationship between the endocrine activity of the pineal gland and the hormones ghrelin and nesfatin-1, which play a critical role in nutrition. Consequently, administration of melatonin inhibits ghrelin but increases nesfatin-1.
2023-01-01T00:00:00ZDietary zinc status in offspring of pregnant rats fed on a zinc-deficient diet is associated with Serum Albumin, Ast, and Alt levelsGümüş, MeltemBaltacı, Saltuk Buğrahttps://hdl.handle.net/20.500.12511/123702024-03-15T10:16:19Z2023-01-01T00:00:00ZDietary zinc status in offspring of pregnant rats fed on a zinc-deficient diet is associated with Serum Albumin, Ast, and Alt levels
Gümüş, Meltem; Baltacı, Saltuk Buğra
Objective: This study was carried out to investigate whether dietary zinc status is associated with serum albumin, AST and ALT levels in male offspring of mother rats fed a zinc deficient diet.
Methods: The study was carried out on male offspring (Groups 1, 2, 3) born to rats fed a zinc deficient diet and on male offspring (Group 4) born to mothers fed a standard diet. Group 1: Zinc deficient, Group 2; standard rat chow, Group 3: Zinc supplemented diet. Animals of group 4 were used as control group. After the completion of the experimental stages of the study, albumin, AST, ALT, free and total bilirubin levels in serum samples taken from animals were determined by spectrophotometric method.
Results: Dietary zinc deficiency (group 1) significantly decreased serum albumin values (p<0.004). Animals in both the zinc deficient (Group 1) group and the Group 2 animals born to mothers fed a zinc deficient diet and fed standard rat chow had the highest AST and ALT levels (p<0.001).
Conclusion:The present study is the first to show that dietary zinc status can directly affect liver function in rats born to zinc deficient mothers by causing changes in serum albumin, AST and ALT levels.
2023-01-01T00:00:00ZPlasma leptin, nesfatin 1, NPY, and zinc levels in obese and metabolic syndrome childrenAydoğdu, AdnanÜnal, ÖmerBaltacı, Saltuk BuğraMenevşe, EsmaMoğulkoç, RasimErdem, Said SamiBüyükinan, MuammerBaltacı, Abdulkerim Kasımhttps://hdl.handle.net/20.500.12511/123552024-03-12T05:40:01Z2023-01-01T00:00:00ZPlasma leptin, nesfatin 1, NPY, and zinc levels in obese and metabolic syndrome children
Aydoğdu, Adnan; Ünal, Ömer; Baltacı, Saltuk Buğra; Menevşe, Esma; Moğulkoç, Rasim; Erdem, Said Sami; Büyükinan, Muammer; Baltacı, Abdulkerim Kasım
Objective: The aim of this study is to investigate the relationship between leptin, nesfatin 1 and NPY hormones and zinc in boys and girls diagnosed with metabolic syndrome and obesity.
Methods: This study included a total of 6 groups. Group 1 Boy Control, Group 2 Girl Control, Group 3 Obese Boys, Group 4 Obese Girls, Group 5 Boys with Metabolic Syndrome, Group 2 with Girls with Metabolic Syndrome. Plasma leptin, nesfatin-1, NPY (by ELISA method) and serum zinc (by AA method) levels were determined in blood samples obtained from the subjects.
Results: Leptin and zinc levels were significantly higher both in boy and girl patients with metabolic syndrome than in obese and control children. Nesfatin-1 and NPY levels were significantly lower both in girl and boy obese and metabolic syndrome children compared to their control groups.
Conclusion: In the current study a significant increase in plasma leptin and serum zinc levels and a significant decrease of plasma nesfatin-1 and NPY levels were observed in boys and girls with metabolic syndrome. The findings of our study show that leptin, nesfatin-1 and NPY levels may be important biomarkers in the assessment of metabolic syndrome risk in both girls and boys.
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