Güncel Gönderiler: Rektörlüğe Bağlı Birimler
Toplam kayıt 553, listelenen: 1-20
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Residues in the fructose-binding pocket are required for ketohexokinase-A activity
(2024)Excessive fructose consumption is a primary contributor to the global surges in obesity, cancer, and metabolic syndrome. Fructolysis is not robustly regulated and is initiated by ketohexokinase (KHK). In this study, we ... -
Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
(2024)Programmed death ligand 1, PD-L1 (CD274), facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a mechanism whereby internalization of PD-L1 in response to alterations of bioactive ... -
I-BaR: integrated balance rehabilitation framework
(2024)Neurological diseases are observed in approximately 1 billion people worldwide. A further increase is foreseen at the global level as a result of population growth and aging. Individuals with neurological disorders often ... -
Synthesis and anticancer activity of novel indole derivatives as dual EGFR/SRC kinase inhibitors
(2024)Background: Recent studies showed that the cooperation between c-SRC and EGFR is responsible for more aggressive phenotype in diverse tumors, including glioblastomas and carcinomas of the colon, breast, and lung. Studies ... -
Smoking affects global and regional brain entropy in depression patients regardless of depression: preliminary findings
(2024)Objective: This study examines the effect of smoking on global and regional brain entropy in patients with Major Depressive Disorder (MDD), aiming to elucidate the relationship between smoking habits and brain network ... -
Investigation of the relationship between upper limb apraxia and neuropsychological profile in alzheimer’s disease dementia and mild cognitive impairment
(2024)Objectives: This study aimed to examine the differences in upper limb apraxia assessments and neuropsychological profiles of patients diagnosed with Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) and ... -
Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress
(2024)Metabolic enzymes can adapt during energy stress, but the consequences of these adaptations remain understudied. Here, we discovered that hexokinase 1 (HK1), a key glycolytic enzyme, forms rings around mitochondria during ... -
Bridging the gap: a narrative review of osteoporosis disability, adipokines, and the role of AI in postmenopausal women
(2024)Osteoporosis is a global health concern characterized by reduced bone density and compromised bone quality, resulting in an increased risk of fractures, particularly in postmenopausal women. The assessment of bone mineral ... -
Splicing variants of versican in CD133+/CD44+ prostate cancer stem cells
(2024)A cancer mass is composed of a heterogeneous group of cells, a small part of which constitutes the cancer stem cells since they are less differentiated and have a high capacity to develop cancer. Versican is an extracellular ... -
Nanoparticle-mediated histotripsy using dual-frequency pulsing methods
(2024)Objective: Nanoparticle-mediated histotripsy (NMH) is a novel ablation method that combines nanoparticles as artificial cavitation nuclei with focused ultrasound pulsing to achieve targeted, non-invasive, and cell-selective ... -
Bioinformatics design of a peptide vaccine containing sarcoma antigen NY-SAR-35 epitopes against breast cancer and evaluation of its immunological function in BALB/c mouse model
(2024)The development of a cancer vaccine has become an essential focus in the field of medical biotechnology and immunology. In our study, the NY-SAR-35 cancer/testis antigen was targeted to design a novel peptide vaccine using ... -
Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo
(2024)Neuronal activity is accompanied by a net outflow of potassium ions (K+) from the intra- to the extracellular space. While extracellular [K+] changes during neuronal activity are well characterized, intracellular dynamics ... -
The effect of chronic swimming exercise and vitamin e supplementation on bone element metabolism in epileptic rats
(2024)Introduction: This study aimed to investigate the effects of chronic swimming exercise and vitamin E administration on elemental levels in the bone tissue of epileptic rats. Methods: Forty-eight rats were divided into six ... -
Investigation of academicians' positive psychological capital perceptions and problem solving skills
(IGI Global, 2024)... -
Potential diagnostic value of abnormal pyroptosis genes expression in myelodysplastic syndromes (MDS): A primary observational cohort study
(2024)Background: Myelodysplastic syndromes (MDS) are determined by ineffective hematopoiesis and bone marrow cytological dysplasia with somatic gene mutations and chromosomal abnormalities. Accumulating evidence has revealed ... -
Two rare autosomal recessive neurological disorders identified by combined genetic approaches in a single consanguineous family with multiple offspring
(2024)Introduction: Neurodevelopmental disorders (NDDs) refer to a broad range of diseases including developmental delay, intellectual disability, epilepsy, autism spectrum disorders, and attention-deficit/hyperactivity disorder ... -
The investigation of inflammation in drug-naive first-episode mania by measuring ferritin, peripheral inflammatory markers, and their ratios
(Istanbul University, 2024)Objective: Bipolar disorder (BD) is a complex psychiatric disorder with a multifactorial etiology involving both genetic and environmental factors. Increased inflammatory parameters have been shown in previous studies in ... -
Reconstructing brain functional networks through identifiability and deep learning
(MIT Press Journals, 2024)We propose a novel approach for the reconstruction of functional networks representing brain dynamics based on the idea that the coparticipation of two brain regions in a common cognitive task should result in a drop in ...