The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses

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2019Author
Yener, Görsev G.Fide, Ezgi
Özbek, Yağmur
Emek Savaş, Derya Durusu
Aktürk, Tuba
Çakmur, Raif
Güntekin, Bahar
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Yener, G. G., Fide, E., Özbek, Y., Emek Savaş, D. D., Aktürk, T., Çakmur, R. ve Güntekin, B. (2019). The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses. International Journal of Psychophysiology, 139, 48-58. https://dx.doi.org/10.1016/j.ijpsycho.2019.03.002Abstract
Event-related oscillatory responses reflect the cognitive status in many neuropsychiatric conditions including mild cognitive impairment (MCI). In this study, a total of 30 patients with amnestic MCI (aMCI) and 25 patients with MCI of Parkinson's disease (PD-MCI) were compared with 28 aged-, gender-, education-matched healthy control (HC) participants using visual event-related delta, theta, alpha oscillatory responses by methods of event related spectral perturbation and inter-trial coherence. PD-MCI and aMCI groups commonly share a decreased theta power, but all electrophysiological deviations from the controls were more prominent in PD-MCI than aMCI in all frequency bands. Additionally, decreased phase-locking in all studied frequency bands was encountered only in PD-MCI group, but it was preserved in aMCI. These findings indicate that visual networks in PD-MCI are more severely affected than aMCI. Reduced phase-locking in PD-MCI may possibly relate to dysfunctioning subcortical modulating centers that take a role in the generation of event-related responses.
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International Journal of PsychophysiologyVolume
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