The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses
AuthorYener, Görsev G.
Emek Savaş, Derya Durusu
MetadataShow full item record
CitationYener, G. G., Fide, E., Özbek, Y., Emek Savaş, D. D., Aktürk, T., Çakmur, R. ve Güntekin, B. (2019). The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses. International Journal of Psychophysiology, 139, 48-58. https://dx.doi.org/10.1016/j.ijpsycho.2019.03.002
Event-related oscillatory responses reflect the cognitive status in many neuropsychiatric conditions including mild cognitive impairment (MCI). In this study, a total of 30 patients with amnestic MCI (aMCI) and 25 patients with MCI of Parkinson's disease (PD-MCI) were compared with 28 aged-, gender-, education-matched healthy control (HC) participants using visual event-related delta, theta, alpha oscillatory responses by methods of event related spectral perturbation and inter-trial coherence. PD-MCI and aMCI groups commonly share a decreased theta power, but all electrophysiological deviations from the controls were more prominent in PD-MCI than aMCI in all frequency bands. Additionally, decreased phase-locking in all studied frequency bands was encountered only in PD-MCI group, but it was preserved in aMCI. These findings indicate that visual networks in PD-MCI are more severely affected than aMCI. Reduced phase-locking in PD-MCI may possibly relate to dysfunctioning subcortical modulating centers that take a role in the generation of event-related responses.