Revealing nervous and cardiac system interactions by iPSC-Based platforms

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dc.authorid0000-0001-5688-136X
dc.authorid0000-0002-7199-583X
dc.contributor.authorMutlu Burnaz, Özlem
dc.contributor.authorÇağavi, Esra
dc.date.accessioned2022-04-22T11:06:17Z
dc.date.available2022-04-22T11:06:17Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyoloji ve Genetik Ana Bilim Dalı
dc.description.abstractCardiac function is regulated by the autonomic nervous system. In exchange, the sensorial information from the heart is relayed to the brain via sensory neurons as a crucial modulatory feedback mechanism. Cardiovascular and neurological diseases constitute the majority of deaths globally. The high morbidity associated with cardiac and neurological disorders is mostly due to the limited number of targeted therapeutics. Moreover, many new drug candidates are withdrawn from clinical use due to cardiotoxicity or neurotoxicity. Previously, experimental animal models, biopsy materials, or immortalized cell lines were the basis of disease studies and drug screens. However, the differences between these models and human physiology particularly in neural and cardiac functions resulted in limited clinical success. To overcome the complications related to the organism mismatch and cell source, human induced pluripotent stem cells (hiPSCs) provide ways to investigate molecular mechanisms in embryonic, adult, and diseased states. hiPSC-derived cardiac cells and various neuron subtypes could replicate complex interactions in the physiologically relevant organoids or multiorgan microdevices. Using these novel technical developments, recent models of neuronal regulation of heart tissue started to provide unique insights in systemic interactions and molecular basis to develop more precise therapeutic approaches. In this chapter, a brief historical perspective and recent advances in iPSC-based models of cardiac and nervous system interactions are reviewed.
dc.identifier.citationMutlu Burnaz, Ö. ve Çağavi, E. (2022). Revealing nervous and cardiac system interactions by iPSC-Based platforms. iPSCs - State of the Science içinde (1-28. ss.). Elsevier. https://doi.org/10.1016/B978-0-323-85767-3.00002-5
dc.identifier.doi10.1016/B978-0-323-85767-3.00002-5
dc.identifier.endpage28
dc.identifier.isbn9780323857673
dc.identifier.isbn9780323856454
dc.identifier.scopus2-s2.0-85128085996
dc.identifier.scopusqualityN/A
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-85767-3.00002-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9358
dc.indekslendigikaynakScopus
dc.institutionauthorMutlu Burnaz, Özlem
dc.institutionauthorÇağavi, Esra
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofiPSCs - State of the Scienceen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardiac Differentiation
dc.subjectCardiac Innervations
dc.subjectCardiology
dc.subjectCardiovascular Disease
dc.subjectInvitro Disease Models
dc.subjectIPSC
dc.subjectMicrofluidics
dc.subjectNervous System
dc.subjectNeural Differentiation
dc.subjectOrgan-on-a-Chip
dc.subjectOrganoids
dc.subjectSensory Neurons
dc.subjectTissue Engineering
dc.titleRevealing nervous and cardiac system interactions by iPSC-Based platforms
dc.typeBook Chapter

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