İstanbul Medipol Üniversitesi Kurumsal Akademik Arşivi
DSpace@Medipol, İstanbul Medipol Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Identifying the most critical side effects of antidepressant drugs: a new model proposal with quantum spherical fuzzy M-SWARA and DEMATEL techniques
(2024) Silahtaroğlu, Gökhan; Dinçer, Hasan; Yüksel, Serhat; Keskin, Abdurrahman; Yılmaztürk, Nevin; Kılıç, Alperen
Identifying and managing the most critical side effects encourages patients to take medications regularly and adhere to the course of treatment. Therefore, priority should be given to the more important ones, among these side effects. However, the number of studies that make a priority examination is limited. There is a need for a new study that determines which of these effects are more priority to increase the quality of the treatment. Accordingly, this study aims to define the most important side effects of antidepressant drugs with a novel model. Quantum Spherical fuzzy M-SWARA technique is considered to compute the importance weights of the items. The main contribution of this study is that the most critical side effects can be understood for antidepressant drugs by establishing a novel decision-making model. The findings demonstrate that psychological side effects are defined as the most critical side effects of antidepressant drugs. Furthermore, physical side effects also play a key role in this condition. Side effects in antidepressant treatment have a great impact on the effectiveness of treatment and patient compliance.
Therapeutic effects of mesenchymal stem cell conditioned medium in rat varicocele model
(2025) Şerefoğlu, Ege Can; Kolbaşı, Bircan; Bülbül, Muhammet Volkan; Karabulut, Seda; Çakıcı, Çağrı; Gündoğdu Özdemir, Reyhan Zeynep; Keskin, İlknur
Purpose: This study aimed to examine the therapeutic effects of injection of conditioned medium of adipose-derived mesenchymal stem cells (ADMSC-CM) in a surgically created varicocele model in comparison with varicocelectomy. Materials and Methods: Twenty-eight male Wistar Albino rats were randomly divided into four groups: sham group, varicocele group, varicocelectomy group, and ADMSC-CM injection group. Sperm parameters were analyzed in samples taken from the epididymis after treatment. Malondialdehyde and superoxide dismutase (SOD) levels in blood samples were examined by biochemical analysis. The testicular tissues were stained with hematoxylin-eosin for histological examination (Johnsen’s Score). Additionally, Western Blot analyzes were performed to detect Claudin-11 levels, the functional protein of the blood-testis barrier, in testicular tissues. Results: Varicocelectomy and ADMSC-CM treatments significantly improved mean sperm parameters (concentration, progressive motility, motility, normal sperm morphology) (p≤0.05 for all). Both treatment groups had increased SOD levels along with a decrease in malondialdehyde levels (p≤0.05 for all). No significant difference was observed between the ADMSC-CM group and the varicocelectomy group in preserving normal testicular histology according to Johnsen’s Score (p=0.114). Levels of Claudin-11 were significantly higher in the varicocelectomy and ADMSC-CM groups compared to the varicocele group (p≤0.05 for all). Conclusions: The therapeutic effects of ADMSC-CM in varicocele model may involve secretion of anti-inflammatory and regenerative factors from ADMSC. ADMSC-CM injection appears to be a promising new strategy in the treatment of varicocele.
Orthopaedic patients’ emergency department attendance behavior in relation to weather conditions: temperature, rain, day and time, and regional thursday effect
(2025) Bayam, Levent; Öznam, Kadir; Güler, Ayşenur; Uyan, Eren; Erdem, Mehmet
Great variation was noticed in emergency department (ED) afflux in relation to daily weather conditions, including difficulties in arranging the correct number of orthopaedic on-calls on the floor. This study aimed to quantify the association between the number of patients referred to the orthopaedic team from the ED and weather conditions, particularly daily temperature and rain. Data were obtained from a large state research hospital’s ED attendance. Weather information for the local area for the year was obtained from the regional meteorological office. Data were evaluated using descriptive statistics, with one-way analysis of variance for the relationship between the day of the week and patient numbers, the Pearson test for correlations between daily ED patient flow and daily temperature and the Spearman correlation test for correlations between daily patient flow and daily rain status. A positive and meaningful correlation existed between daily patient influx and daily temperature, along with a negative correlation between daily patient flow and daily rain. Throughout the year, significantly more patients were referred to the orthopaedic team on Thursdays than on any other day of the week. Patients tended to visit the ED more on warm days and days without rain. These results may help in organising daily, monthly or seasonal on-call orthopaedic team requirements despite the challenges. Incorporating climate forecasts into planning the on-call service might help alleviate the stress on the team.
Correction: Consensus statement addressing controversies and guidelines on pediatric urolithiasis
(2024) Güven, Selçuk; Tokas, Theodoros; Tozsin, Atınç; Haid, Barbara; Lendvay, Thomas Sean; Sılay, Şerife; Sarıca, Kemal
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Reliability and validity assessment of the Turkish version of the emotional availability and responsiveness in intrapartum care scale (ear-ic)
(2024) Yıldırım Varışoǧlu, Yeliz; Irmak Vural, Pınar
Background: Emotional availability and responsiveness in intrapartum care increase women's birth satisfaction, comfort, and quality of nursing/midwifery care. In Turkey, there is no instrument for measuring emotional availability and responsiveness in intrapartum care. Aim: An established translation, reliability, and validation approach was used to obtain the Turkish form of the A-EAR-IC scale. Methods: A descriptive cross-sectional study was used. This study was conducted in Istanbul, Turkey. The study sample consisted of 132 Turkish midwives working in the birth room. The construct validity of the scale was tested using confirmatory factor analysis, whereas the concurrent scale validity was tested using the Emotional Labor Behavior Scale. Internal consistency analysis was performed to test the reliability of the scale. Results: The results of the EAR-IC measure showed that it fit the one-factor model. The goodness-of-fit indices of the one-factor model containing eight items were acceptable. The instrument showed satisfactory content validity (I-CVI =0.80-1.00, S-CVI =0.88). According to CFA, the structure with one factor showed acceptable model fit ( χ2/df: 1.74, CFI: 0.96, IFI: 0.96, RMSEA: 0.07, and SRMR: 0.02). Concurrent validity of the instrument was assessed with the "in-depth behavior"subscale of the Emotional Labor Behavior Scale for Nursing. Spearman's correlations revealed that the EAR-IC was moderately positively correlated with the in-depth behavior concern subscale of the ELBS (rho =0.62, P < 0.001). Conclusion: The Turkish version of the EAR-IC is a suitable, effective, and reliable instrument for measuring the emotional aspects of intrapartum caregiving midwives.
