İstanbul Medipol Üniversitesi Kurumsal Akademik Arşivi
DSpace@Medipol, İstanbul Medipol Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The Islamic economic system: cultural context in a global economy
(Taylor and Francis, 2024) Awais, Muhammad; Öztürk, Ali Osman; Bhatti, Omar Khalid; Ellahi, Nazima
Islamic Economics refers to financial aspects or monetary activities and processes, which adhere to Islamic standards and teachings. The Islamic Economic System relates to the hypothetical development of an economy whose individuals follow the Islamic faith. This book presents an interesting and timely narrative of the concepts of Islamic economics in the context of Islamic culture. Its purpose is to guide individuals and organizations towards a Shariah-based Islamic Economic System. It begins by introducing the Islamic Economic System; its historical origins are explained in the framework of the verses of the Holy Quran, and in light of the Shariah scholars and the philosophical thinkers of the mid-20th century. It discusses concepts such as the evolution of Islamic Fintech and Artificial Intelligence (AI); the relationship between Islamic corporate governance and Islamic Economics; the distribution of wealth in Islam; Islamic Social Finance; Islamic Economic practices in the banking industry, behavioural norms and moral foundations; and Islamic Economics in Organisation of Islamic Cooperation (OIC) and non-OIC countries. The author emphasizes the principles that set Islamic economics apart from traditional systems, grounded in Shariah evidence and highlights the role of Islamic principles in promoting overall business success and ethical practices in the banking industry, offering comparative analysis between Islamic and conventional models, as well as economic systems. Drawing on a rich array of sources, including the Quran and interviews with renowned religious scholars, the book provides a well-rounded and thoroughly researched argument. This book will serve as a valuable resource for academics, scholars, researchers, and organizations seeking to navigate the complexities of an interest-free economic system guided by Islamic principles.
Investigation of in vitro wound healing properties of salvia sclarea and citrus aurantium essential oil combinations
(2024) Karadağ, Ayşe Esra; Demirci, Betül; Şakar, Zeynep Zişan; Biltekin, Sevde Nur
Salvia sclarea L. and Citrus aurantium L. are used ethnobotanically for wound treatment. The aim of this study was to evaluate phytochemical composition of Salvia sclarea L. and Citrus aurantium L. leaf essential oils and wound healing activities of their combinations. The phytochemical analysis was performed gas chromatography (GC) and mass spectroscopy (MS). Major components of S. sclarea leaf essential oil was confirmed both by GC-FID and GC/MS as 67% linalyl acetate, 20.2% linalool, 2.6%α-terpineole, respectively. The major components of C. aurantium leaf essential oil was also confirmed as 55% linalyl acetate, 23.4% linalool, 5.4%α-terpineole, respectively. Combinations of essential oils were loaded into Carbopol gel formulations. Wound healing activity of essential oil and combinations was investigated using in vitro scratch assay. As a result of the study, it was determined that the most effective wound healing concentration for Salvia sclarea essential oil was 50 µg/mL. The most effective concentration of Citrus aurantifolia essential oil was determined as 12.5 µg/mL. The aim of the study is to investigate the wound healing activities of the tested essential oils individually and in combination. The fact that no activity is observed in empty formulations is evidence that the activity of the loaded formulations does not come from empty formulations. It was observed that the loaded formulations showed better effects than the control Madecassol. Studies need to be confirmed by working under in vivo conditions.
Evaluation of patch test results with the t.r.u.e. test and demographic findings in periorbital dermatitis: a 10-year retrospective analysis
(2024) Ünal, Alkım
The most common cause of periorbital dermatitis is allergic contact dermatitis. This study aimed to determine the patch test results and demographic characteristics in patients diagnosed with periorbital dermatitis by evaluating their patch test results between 2012 and 2022. The thin-layer rapid-use epicutaneous test (T.R.U.E. test) results of patients diagnosed with periorbital dermatitis over the specified period were retrospectively evaluated. Of the 102 patients included in the study, 58 (56.9%) had a positive reaction to at least one allergen. The most common allergens to which the patients had positive reactions were nickel sulfate (31.0%), gold sodium thiosulfate (19.0%), fragrance mix (13.8%), balsam of Peru (10.3%), colophony (10.3%), cobalt dichloride (8.6%), formaldehyde resin (6.9%), thimerosal (5.2%), quaternium-15 (5.2%), carba mix (5.2%), and potassium dichromate (5.2%). This study provides comprehensive data on the demographic characteristics and patch test results of patients with periorbital dermatitis.
Development and validation of an RP-HPLC method to compare the apoptotic activity of quercetin found in marketed dietary supplements
(2024) Erim, Ümit Can; Ayşit, Neşe
Quercetin is a ubiquitous bioactive flavonoid found in broad selection of dietary supplements. It has potential beneficial health effects and induces therapeutic activity in many diseases including different types of cancer. Quercetin exerts cytotoxic activity in cancer and induces apoptotic cell death. Albeit, each dietary supplement consists of impurities, which in turn diminish the biological activity of the quercetin. Herein, we extracted quercetin from 5 different marketed dietary supplements in tablet formulation and detected their quercetin content by developing and validating an RP-HPLC method. We further investigated the cytotoxic activity of quercetin and its role in apoptosis through mitochondrial pathway in MCF-7 and 4T1 breast cancer cell lines. Our findings demonstrated that the quercetin content in all formulations was less than the amount stated in the labeling information, nevertheless they exerted significant cytotoxic activities in breast cancer cells. We revealed that formulations with high quercetin content induced apoptosis through restoring the tumor suppression activity of p53 and activating downstream caspases, whereas the formulation with low quercetin content potentially induced non-apoptotic cell death. Our work illustrates the involvement of quercetin in apoptosis through the mitochondrial pathway in accordance with the quercetin content detected by the RP-HPLC.
Histological and scanning electron microscopy investigation of the effects of titanium surface modifications on osseointegration in rabbits
(2024) Aydın, Burak; Öztemür, Zekeriya; Yeldir, Neşe; Kılınç, Seyran; Aktı, Sefa; Bilgin, İsmail
Objective: This study aimed to compare the novel Estaş Medical Anodization (EMA) surface treatment technique with the techniques commonly used in the literature and to examine their effects on osteointegration in the rabbit tibia. Methods: A total of 24 rabbits used in this study were divided into 3 groups, with 8 rabbits in each group. Using both tibias of all rabbits in the study, screws belonging to the control group were placed in the left tibia, and the right tibia belonging to the experimental group were placed. In the first 8 rabbits, a single experimental group in the right tibia were used; in the second 8 rabbits, 2 different experimental groups in the right tibia were used; and in the last 8 rabbits, 2 different experimental groups in the right tibia were used. Thus, 5 different experimental groups with 8 screws in each group and a separate control group were formed for each of them. EMA-treated surfaces were named 200-800 nm iris oxidation and 800-1200 nm gray oxidation according to the TiO2 layer thickness. Group 1 was implanted with mini-screws prepared with chemical etching + EMA iris oxidation, while group 2 was implanted with sandblasted, large-grit and acid-etched (SLA) mini screws treated with EMA gray oxidation. Group 3 was implanted with mini-screws treated with EMA gray oxidation, group 4 was implanted with mini-screws treated with chemical etching + micro-arc oxidation, and group 5 was implanted with mini-screws treated with chemical etching + EMA gray oxidation. The control group was implanted with mini-screws prepared with pure titanium. At the end of 6 weeks, osseointegration percentages were calculated and compared using histological and scanning electron microscope (SEM) analyses. Results: The histological results confirmed the increase in osseointegration percentages in all experimental groups compared to those that received pure titanium implants (P values control group vs group 1 = .005, control group vs group 2, 3, 4, 5 = .001). The comparison between the groups revealed that the chemical etching + EMA gray oxidation modification technique (group 5) significantly increased osseointegration compared to the SLA + EMA gray oxidation technique (group 5 vs group 2 P = .016) and the chemical etching + EMA iris oxidation technique (group 5 vs group 1 Pp = .001). The EMA gray oxidation technique (group 3) significantly increased osseointegration compared to the chemical etching + EMA iris oxidation technique (group 1) (group 3 vs group 1 P = .043). The results of the SEM analysis showed that osseointegration was significantly increased in all experimental groups compared to that in the pure titanium (control) group (P values control group vs group 1, 2, 3 = .001, control group vs Group 4,5 = .006). The mean osseointegration percentage in the experimental groups was the highest in group 5, followed by group 4, group 3 and group 1 equally, and group 2. However, the differences among the experimental were not significant (group 1, group 2, group 3, group 4 vs group 5 P = .408). Conclusion: The EMA titanium surface modification techniques we developed significantly increased osseointegration compared to the pure titanium surface. The EMA gray oxidation technique seems to result in higher osseointegration rates than the EMA iris oxidation technique, and similar rates can be found with the SLA and chemical etching techniques.
