İstanbul Medipol Üniversitesi Kurumsal Akademik Arşivi
DSpace@Medipol, İstanbul Medipol Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Infective endocarditis: the evaluation of 64 cases
(2024) Aydın, Selda; Şahin, Meyha; Yılmaz, Ezgi; Mert, Ali
Introduction: Infective endocarditis (IE) remains an important infectious disease with a high mortality rate despite advancements in diagnostic and therapeutic methods. Our study aimed to determine the demographic characteristics, clinical, microbiologic, and imaging findings, treatment modalities and clinical outcomes, and factors affecting mortality in IE cases. Materials and Methods: The study was retrospectively designed in a tertiary university hospital. Between January 2015 and December 2023, 64 cases of definite and probable IE in individuals over the age of 18, defined according to the 2023 Duke IE criteria by The International Society for Cardiovascular Infectious Diseases, were included in the study. Results: The median age was 61.5 years (interquartile range= 48-74 years) and 69% (n= 44) were male. The most common symptoms and signs were fever (84.3%), murmur (62.5%), and embolic events (25%). Definite IE was diagnosed in 91% (n= 58) and probable IE in 9% (n= 6) of the patients. Natural valve IE was identified in 51.6% of cases, prosthetic valve IE in 34.4%, and pacemaker IE in 14%. The most commonly affected valves were mitral (35.6%) and aortic (33.3%) valves. Microbiological diagnostic methods identified the causative agent in 89.1% of cases. The most frequently isolated microorganisms were staphylococci (43.8%) and enterococci (21.9%). Surgery was performed in 50% of the patients. The mortality rate during hospitalization was 22%. Higher mortality rates were observed in the presence of advanced age, coronary artery disease, chronic kidney disease, and pacemaker endocarditis. Conclusion: It is noteworthy that the average age of patients with IE is increasing, staphylococci are the predominant microbiological agent, and patients with endocarditis associated with advanced age, chronic kidney disease, and the presence of a pacemaker have a more severe prognosis. These findings emphasize the critical importance of IE management being conducted by an IE team, as recommended in the European Society of Cardiology 2023 endocarditis guidelines.
Achieving high accuracy in meniscus tear detection using advanced deep learning models with a relatively small data set
(2025) Güngör, Erdal; Vehbi, Husam; Cansın, Ahmetcan; Ertan, Mehmet Batu
Purpose: This study aims to evaluate the effectiveness of advanced deep learning models, specifically YOLOv8 and EfficientNetV2, in detecting meniscal tears on magnetic resonance imaging (MRI) using a relatively small data set. Method: Our data set consisted of MRI studies from 642 knees—two orthopaedic surgeons labelled and annotated the MR images. The training pipeline included MRI scans of these knees. It was divided into two stages: initially, a deep learning algorithm called YOLO was employed to identify the meniscus location, and subsequently, the EfficientNetV2 deep learning architecture was utilized to detect meniscal tears. A concise report indicating the location and detection of a torn meniscus is provided at the end. Result: The YOLOv8 model achieved mean average precision at 50% threshold (mAP@50) scores of 0.98 in the sagittal view and 0.985 in the coronal view. Similarly, the EfficientNetV2 model obtained area under the curve scores of 0.97 and 0.98 in the sagittal and coronal views, respectively. These outstanding results demonstrate exceptional performance in meniscus localization and tear detection. Conclusion: Despite a relatively small data set, state-of-the-art models like YOLOv8 and EfficientNetV2 yielded promising results. This artificial intelligence system enhances meniscal injury diagnosis by generating instant structured reports, facilitating faster image interpretation and reducing physician workload. Level of Evidence: Level III.
The tdq-60 tr-a picture-naming test to assess anomia in Turkish adults and the elderly: normative data and validation study in alzheimer's disease and mild cognitive impairment
(2025) Karalı, Fenise Selin; Tosun, Samet; Eskioğlu, Elif İkbal; Çınar, Nilgün; Macoir, Joël
Objective: Anomia is defined by difficulty in retrieving content words like nouns and verbs from long-term memory, independent of any impairments related to articulatory movements or motor speech execution. The tools for measuring picture naming, the conventional method for assessing anomia, are very limited in Turkey. The aim of this study was to adapt the Test de Dénomination de Québec—60 images/Quebec picture-naming test—60 pictures (TDQ-60), a color picture-naming test for adults and the elderly into Turkish, establish its validity, and develop normative data adapted to the Turkish population to address this gap. Method: We conducted three separate studies. The objective of Study 1 was to culturally adapt the Test de Dénomination de Québec—60 images. In Study 2, we developed normative data for the TDQ-60 Tr adapted to the adult and elderly population in Turkey based on the performance of 414 community residents aged 18 years and older. In Study 3, the known-group validity, the convergent validity, and the test–retest validity of the TDQ-60 Tr were determined. Results: The results show that the TDQ-60 Tr is reliable in distinguishing participants with Alzheimer’s disease and mild cognitive impairment from healthy participants. The TDQ-60 Tr measures the same cognitive construct as the Boston Naming Test and also has a high test–retest reliability. Conclusions: In summary, the TDQ-60 Tr is a valid and reliable instrument for assessing naming abilities in adults and the elderly. The results of this study have significant implications for the assessment of naming ability in Turkish-speaking patients. Our work serves as a crucial connection to address the lack of tools for diagnosing anomia in Turkey.
Anatomical spread of local anesthetic in circumpsoas block: a cadaveric study
(2025) Atalay, Yunus Oktay; Sözcü, Semih Burak; Tekin, Bahar; Ansen, Gamze; Cingöz, Gözde; Şakul, Bayram Ufuk; Alıcı, Haci Ahmet
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Trimethylamine n-oxide (tmao) and tnf-α levels in periodontal disease associated with smoking
(2025) Bal, İpek; Balcı, Nur; Sorguç, Cem; Uslu Toygar, Hilal; Ceran Serdar, Ceyhan; Kurgan, Şivge; Serdar, Muhittin
Aims: Trimethylamine N-oxide (TMAO) is a compound involved in the pathogenesis of various systemic inflammatory diseases, including cardiovascular conditions. The aim of this study was to determine differences in saliva and serum levels of TMAO between periodontitis and healthy patients according to smoking status. Methods: The study included four systemically healthy groups: periodontally healthy non-smokers (NS-Control; n = 25), non-smokers with Stage-III-Grade-B periodontitis (NS-Periodontitis; n = 25), periodontally healthy smokers (S-Control; n = 25), and smokers with Stage-III Grade-C periodontitis (S-Periodontitis; n = 25). Periodontal parameters were recorded. TMAO levels were determined in saliva and serum samples using liquid chromatography-mass spectrometry (LC–MS/MS). TNF-α levels were measured by the ELISA method. Results: Salivary TNF-α and TMAO levels were significantly elevated in the smoking periodontitis group compared to other groups (p < 0.001 and p = 0.003, respectively). Serum TMAO levels were also significantly higher in the smoking periodontitis group compared to non-smoking controls and non-smoking periodontitis. TMAO/SFR ratios were notably higher in the smoking periodontitis group compared to other groups, and a strong positive correlation was observed between salivary TMAO and TNF-α levels (r = 0.892, p < 0.001). Conclusion: The data suggested that TMAO and TNF-α are associated with inflammatory mechanisms of periodontitis in cases where periodontitis coexists with smoking. Trial Registration: NCT06580431.
