Cytotoxic effects of various lactic acid bacteria on Caco-2 cells

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dc.contributor.authorEr, Sevda
dc.contributor.authorKoparal, Ayşe Tansu
dc.contributor.authorKıvanç, Merih
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:19:05Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:19:05Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractProbiotics are live microbial food supplements that can be considered a functional food. They benefit the health of a host animal by maintaining their intestinal microbial balance. Most probiotic microorganisms are lactic acid bacteria (LAB) such as Lactobacillus spp., Bifidobacterium spp., and Enterococcus spp. LAB have been reported to possess certain anticancer properties. The vast majority of studies on their anticancer effects have dealt with colorectal cancers, although there have also been some studies on breast and bladder cancers. Colon cancer is the fourth most common cause of cancer-related mortality in the world. The aim of this study was to investigate the antiproliferative effects of the cell-free filtrate and the cell-free lyophilized filtrate of 3 LAB (Pediococcus pentosaceus, Lactobacillus plantarum, and Weissella confusa) on human colorectal adenocarcinoma cell line Caco-2. The filtrates were found to inhibit the growth of colon cancer cells in a dose-dependent manner as detected by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, suggesting that these strains might have use as probiotics in functional food or for colon cancer treatment. There are no other studies related to the anticancer activities of W. confusa in the literature.
dc.identifier.citationEr, S., Koparal, A. T. ve Kıvanç, M. (2015). Cytotoxic effects of various lactic acid bacteria on Caco-2 cells. Turkish Journal of Biology, 39(1), 23-30. https://dx.doi.org/10.3906/biy-1402-62
dc.identifier.doi10.3906/biy-1402-62
dc.identifier.endpage30
dc.identifier.issn1300-0152
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage23
dc.identifier.urihttps://hdl.handle.net/20.500.12511/600
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1402-62
dc.identifier.volume39
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherScientific and Technical Research Council of Turkey
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProbiotics
dc.subjectLactic Acid Bacteria
dc.subjectCell-Free Filtrate
dc.subjectCaco-2
dc.subjectMTT Assay
dc.titleCytotoxic effects of various lactic acid bacteria on Caco-2 cells
dc.typeArticle

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