ORCID "0000-0003-0352-1947" Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) için listeleme
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Active shrinkage protects neurons following axonal transection
Aydın, Mehmet Şerif; Bay, Sadık; Yiğit, Esra Nur; Özgül, Cemil; Kaval Oğuz, Elif; Yenidünya Konuk, Elçin; Ayşit, Neşe; Cengiz, Nureddin; Erdoğan, Ender; Him, Aydın; Koçak, Mehmet; Eroğlu, Emrah; Öztürk, Gürkan (Elsevier Inc., 2023)Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water ... -
Aksolotl rejenerasyonunun farklı evrelerinde miRNA profilinin bulunması ve bulunan miRNA'ların görevlerinin in-siliko analizi
Giriş ve Amaç: Rejenerasyon, fonksiyonel bir kayıp yaşamadan hasarlı dokunun, organın ya da uzvun restore edilmesi işlemidir. Su semenderlerinden olan Aksolotl kendisini öldürmeyecek iç organ, merkezi sinir sistemi ve uzuv ... -
Axolotl cells and tissues enhances cutaneous wound healing in mice
Demircan, Turan; Keskin, İlknur; Günal, Yalçın; İlhan, Ayşe Elif; Kolbaşı, Bircan; Öztürk, Gürkan (2016)Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar ... -
Bioinspired scaffold induced regeneration of neural tissue
Altun, Esra; Aydoğdu, Mehmet Onur; Toğay, Sine Özmen; Şengil, Ahmet Zeki; Ekren, Nazmi; Erginer Hasköylü, Merve; Toksoy Öner, Ebru; Altuncu, Neşe A.; Öztürk, Gürkan; Crabbe-Mann, Maryam; Ahmed, Jubair; Gündüz, Oğuzhan; Edirisinghe, Mohan (Pergamon-Elsevier Science Ltd, 2019)In the last decade, nerve tissue engineering has attracted much attention due to the incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold induced nanofibrous structures using both bio ... -
A comparative study of fixatives for axolotl blastema tissue
Keskin, İlknur; Yıldırım, Berna; Kolbaşı, Bircan; Öztürk, Gürkan; Demircan, Turan (Soc Chilena Anatomia, 2017)Regeneration is defined as tissue renewal and functional restoration process of the damaged parts of the body after an injury. Ambystoma mexicanum, commonly named the Axolotl, is one of the unique vertebrates, which has a ... -
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
Sibai, Mustafa; Altuntaş, Ebru; Süzek, Barış Ethem; Şahin, Betül; Parlayan, Cüneyd; Öztürk, Gürkan; Baykal, Ahmet Tarık; Demircan, Turan (Elsevier, 2020)The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
Demircan, Turan; Keskin, İlknur; Dumlu, Seda Nilgün; Aytürk, Nilüfer; Avşaroğlu, Mahmut Erhan; Akgün, Emel; Öztürk, Gürkan; Baykal, Ahmet Tarık (Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
Development of a chemogenetic approach to manipulate intracellular pH
Zaki, Asal Ghaffari; Miri, Seyed Mohammad; Çimen, Şeyma; Akgül Çağlar, Tuba; Yiğit, Esra Nur; Aydın, Mehmet S.; Öztürk, Gürkan; Eroğlu, Emrah (American Chemical Society, 2023)Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
Bay, Sadık; Öztürk, Gürkan; Emekli, Nesrin; Demircan, Turan (Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
Evaluation of the bilateral cardiac afferent distribution at the spinal and vagal ganglia by retrograde labeling
Akgül Çağlar, Tuba; Durdu, Zeynep Begüm; Turhan, M. U.; Günal, Mehmet Yalçın; Aydın, Mehmet Şerif; Öztürk, Gürkan; Çağavi, Esra (Elsevier, 2021)The identity of sensory neurons innervating the heart tissue and the extent of information reported to the brain via these neurons are poorly understood. In order to evaluate the multidimensional distribution and abundance ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Experimental data of labeling the heart and cardiac cultures with a retrograde tracer in vitro and in vivo
Akgül Çağlar, Tuba; Günal, Mehmet Yalçın; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Elsevier Inc., 2021)Retrograde dyes are often used in basic research to investigate neuronal innervations of an organ. This article describes the experimental data on the application of retrograde dyes on the mouse heart in vivo and on the ... -
Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota
Demircan, Turan; Ovezmyradov, Guvanch; Yıldırım, Berna; Keskin, İlknur; İlhan, Ayşe Elif; Fesçioğlu, Ece Cana; Öztürk, Gürkan; Yıldırım, Süleyman (Nature Publishing Group, 2018)Axolotl (Ambystoma mexicanum) is a critically endangered salamander species and a model organism for regenerative and developmental biology. Despite life-long neoteny in nature and in captive-bred colonies, metamorphosis ... -
Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation
Kandemir, Başak; Davis, Sabrina; Yiğit, Esra Nur; Öztürk, Gürkan; Yılmaz, Bayram; Laroche, Serge; Aksan Kurnaz, Işıl (Elsevier Ireland Ltd, 2020)Pea3 proteins belong to a subfamily of the E-twentysix (ETS) domain superfamily of transcription factors, which play various roles during development. Polyoma Enhancer-Activator 3 (Pea3) proteins Pea3, ERM and Er81 are ... -
High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts
Göktaş Şahoğlu, Sevilay; Kazcı, Yusuf Enes; Karadoğan, Behnaz; Aydın, Mehmet Şerif; Nebol, Aylin; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Wiley, 2023)The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2-expressing cardiac afferent fibers of spinal ... -
A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
Demircan, Turan; İlhan, Ayşe Elif; Aytürk, Nilüfer; Yıldırım, Berna; Öztürk, Gürkan; Keskin, İlknur (Elsevier GmbH, 2016)Axolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to ... -
An improved platform for cultured neuronal network electrophysiology: Multichannel optogenetics integrated with MEAs
Bayat, Fazlı Kemal; Alp, Muhammed İkbal; Bostan, Sevginur; Gülçür, Halil Özcan; Öztürk, Gürkan; Güveniş, Albert (Springer, 2022)Cultured neuronal networks (CNNs) are powerful tools for studying how neuronal representation and adaptation emerge in networks of controlled populations of neurons. To ensure the interaction of a CNN and an artificial ... -
An in vitro model for conditioning lesion effect
Kaval Oğuz, Elif; Öztürk, Gürkan (Springer/Plenum Publisher, 2019)Axons of a peripheral nerve grow faster after an axotomy if it attains a prior injury a few days earlier. This is called conditioning lesion effect (CLE) and very much valued since it may provide new insights into neuron ...