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Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl

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Date

2020

Author

Sibai, Mustafa
Altuntaş, Ebru
Süzek, Barış Ethem
Şahin, Betül
Parlayan, Cüneyd
Öztürk, Gürkan
Baykal, Ahmet Tarık
Demircan, Turan

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Sibai, M., Altuntaş, E., Süzek, B. E., Şahin, B., Parlayan, C., Öztürk, G. ... Demircan, T. (2020). Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl. Biochemical and Biophysical Research Communications, 522(2), 428-434. http://doi.org/10.1016/j.bbrc.2019.11.118

Abstract

The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are experimentally induced to metamorphosis, attenuation of the limb's regenerative competence is noticeable. Here, we sought to discern the proteomic profiles of the early stages of blastema formation of neotenic and metamorphic axolotls after limb amputation by employing LC-MS/MS technology. We quantified a total of 714 proteins and qRT-PCR for selected genes was performed to validate the proteomics results and provide evidence for the putative link between immune system activity and regenerative potential. This study provides new insights for examination of common and distinct molecular mechanisms in regeneration-permissive neotenic and regeneration-deficient metamorphic stages at the proteome level.

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Q2

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Source

Biochemical and Biophysical Research Communications

Volume

522

Issue

2

URI

http://doi.org/10.1016/j.bbrc.2019.11.118
https://hdl.handle.net/20.500.12511/4749

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  • Scopus İndeksli Yayınlar Koleksiyonu [5794]
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