Yazar "Üstündağ Okur, Neslihan" için Makale Koleksiyonu listeleme
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Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation
Arpa, Muhammet Davut; Seçen, İkbal Merve; Erim, Ümit Can; Hoş, Ayşegül; Üstündağ Okur, Neslihan (Taylor & Francis Ltd, 2022)In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
Arpa, Muhammet Davut; Üstündağ Okur, Neslihan; Gök, Mehmet Koray; Özgümüş, Saadet; Cevher, Erdal (Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet
Gökçe, Evren Homan; Kaynak, Mustafa Sinan; Yurdasiper, Aysu; Üstündağ Okur, Neslihan; Şahin, Selma (Marmara University, 2018)The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it is limited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are ... -
Development and characterization of voriconazole loaded in situ gel formulations for ophthalmic application
Üstündağ Okur, Neslihan; Yoltaş, Ayşegül; Yozgatlı, Vildan (Turkish Pharmacists Assoc, 2016)The aim of the this research was to prepare and evaluate the potential use of in situ gel formulations for ocular delivery of voriconazole for the treatment of fungal keratitis. An in situ gelling system was used to increase ... -
Development and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation
Üstündağ Okur, Neslihan; Çağlar, Emre Sefik; Yozgatlı, Vildan (Marmara University, 2016)The aim of the present study was to develop and validate a High-Performance Liquid Chromatography (HPLC) method for the determination of voriconazole in drug substances and in situ gel. A mixture of acetonitrile and ultrapure ... -
Development, characterization of naringenin-loaded promising microemulsion formulations, and demonstration of anti-aging efficacy by in vitro enzyme activity and gene expression
Şahin, Dilara; Çağlar, Emre Şefik; Boran, Tuğçe; Karadağ, Ayşe Esra; Özhan, Gül; Üstündağ Okur, Neslihan (Editions de Sante, 2023)This study aims to produce microemulsion formulations containing naringenin for anti-aging reasons. For this purpose, formulations of topical microemulsions including different cosurfactants and surfactants were developed, ... -
Effect of microemulsion formulation on biodistribution of Tc-99m-Aprotinin in acute pancreatitis models induced rats
İlem Özdemir, Derya; Üstündağ Okur, Neslihan; Ay Şenyiğit, Zeynep; Oruç, Nevin; Aşıkoğlu, Makbule; Özütemiz, Ömer; Karasulu Yeşim, Hatice (Taylor & Francis, 2016)Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory ... -
Evaluation of in situ gel containing pycnogenol for cutaneous wound healing
Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ... -
Formulation of microemulsions for dermal delivery of Cephalexin
Üstündağ Okur, Neslihan; Er, Sevda; Çağlar, Emre Şefik; Ekmen, Tarık Ziya; Sala, Furkan (University of Istanbul, 2017)Introduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery ... -
Hemostatic activity of cistus creticus extract in wistar albino rats
Karadağ, Ayşe Esra; Çaşkurlu, Ayşegül; Okur, Mehmet Evren; Güzelmeriç, Etil; Üstündağ Okur, Neslihan; Tosun, Fatma; Yeşilada, Erdem; Demirci, Fatih (Springer Nature, 2020)Aerial part preparations of Cistus creticus L., Cistaceae, are traditionally used in Anatolia as a hemostatic agent. The air-dried aerial parts were extracted with methanol. Gels were prepared, followed by the hemostatic ... -
Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers
Üstündağ Okur, Neslihan; Yozgatlı, Vildan; Okur, Mehmet Evren; Yoltaş, Ayşegül; Siafaka, Panoraia, I. (Elsevier Science Bv, 2019)The aim of this research was to evaluate the potential use of in situ gel formulations for voriconazole ocular delivery as fungal keratitis treatment. The in situ gelling system was applied to increase residence time and ... -
In vivo wound healing and in vitro anti-inflammatory activity evaluation of phlomis russeliana extract gel formulations
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Üstündağ Okur, Neslihan; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Demirci, Betül; Demirci, Fatih (MDPI, 2020)The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana ... -
Investigation of antimicrobial activities of some herbs containing essential oils and their mouthwash formulations
Kulaksız, Büşra; Er, Sevda; Üstündağ Okur, Neslihan; Saltan İşcan, Gülçin (Turkish Pharmacists Association, 2018)Objectives: The aim of this study was to prepare pharmaceutical formulations of mouthwashes and to examine the antimicrobial activities of essential oils obtained from plants used traditionally in Turkey for oral infections. ... -
New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
Arpa, Muhammet Davut; Yoltaş, Ayşegül; Onay Tarlan, Ecehan; Şahin Şenyüz, Cemre; Sipahi, Hande; Aydın, Ahmet; Üstündağ Okur, Neslihan (Taylor and Francis Ltd., 2020)The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
Üstündağ Okur, Neslihan; Filippousi, Maria; Okur, Mehmet Evren; Ayla, Şule; Çağlar, Emre Şefik; Yoltaş, Ayşegül; Siafaka, Panoraia I (Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
A novel approach in the treatment of osteoarthritis: In vitro and in vivo evaluation of Allium sativum microemulsion
Okur, Mehmet Evren; Kolbaşı, Bircan; Şahin, Mustafa; Karadağ, Ayşe Esra; Reis, Rengin; Çağlar, Emre Şefik; Kaplan, Arife Ahsen; Sipahi, Hande; Keskin, İlknur; Demiralp, Bahtiyar; Üstündağ Okur, Neslihan (Wiley, 2022)Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to ... -
Novel microemulsion containing benzocaine and fusidic acid simultaneously: Formulation, characterization, and in vitro evaluation for wound healing
Arpa, Muhammet Davut; Çağlar, Emre Şefik; Güreşçi, Dilara; Sipahi, Hande; Üstündağ Okur, Neslihan (Springer Science and Business Media Deutschland GmbH, 2024)Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate and localize. The goal of this study was ... -
An optimization study on solid lipid nanoparticles using artificial neural network
Yurdasiper, Aysu; Aksu, Buket; Üstündağ Okur, Neslihan; Gökçe, Evren Homan (Colegio Farmaceuticos Provincia De Buenos Aires, 2017)Common use of supportive programs in finding the best in R&D studies provides positive results and thus ensures benefits to companies in terms of cost and time. The aim of this work was to develop, evaluate and optimize ... -
Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine
Üstündağ Okur, Neslihan; Çağlar, Emre Şefik; Arpa, Muhammet Davut; Karasulu, Hatice Yeşim (Taylor & Francis Ltd, 2017)The purpose of the current research was to prepare and evaluate the potential use of microemulsion-based hydrogel (MBH) formulations for dermal delivery of benzocaine (BZN). The pseudoternary-phase diagrams were constructed ... -
Prunus spinosa L. meyvelerinin deneysel yara iyileşmesi üzerine etkileri
Ayla, Şule; Günal, Mehmet Yalçın; Sayın Şakul, Ayşe Arzu; Biçeroğlu, Özge; Özdemir, Ekrem Musa; Okur, Mehmet Evren; Polat, Derya Çiçek; Üstündağ Okur, Neslihan; Bilgiç, Bülent Emre (2017)Farelerde oluşturduğumuz deneysel yara modellerinde, Prunus Spinosa L. metanollü meyve ekstresini kullanarak, bu ekstrenin yara iyileşmesindeki etkisini araştırdık. Otuz iki adet C57/Black fare ile 4 deney grubu oluşturuldu. ...