• Chemical compositon, antibacterial and antioxidant activities of Cnidium silaifolium ssp. orientale (Boiss.) Tutin essential oils 

  Karadağ, Ayşe Esra; Demirci, Betül; Çeçen, Ömer; Tosun, Fatma; Demirci, Fatih (Consejo Superior de Investigaciones Científicas (CSIC), 2021)

  The chemical compositions of the essential oils (EOs) obtained by hydrodistillation from different parts of Cnidium silaifolium ssp. orientale (Boiss.) Tutin were analyzed both by GC-FID and GC/MS, simultaneously. One ...

• Formulation development of liposomal coffee extracts and investigation of their antioxidant capacities 

  Macit, Meltem; Eyüpoğlu, Ozan Emre; Macit, Çağlar; Duman, Gülengül (Editions de Sante, 2021)

  he main objective of this study was to carry out the antioxidant capacity of a liposomal formulation either green coffee extract (GCE) and medium roasted coffee extract (RCE) in aq. and MeOH. First, the coffee beans were ...

• Current status of mucoadhesive gel systems for buccal drug delivery 

  Üstündağ Okur, Neslihan; Özcan Bülbül, Ece; Yağcılar, Ayşe Pınar; Siafaka, Panoraia I (Bentham Science Publishers Ltd, 2021)

  Background: Buccal drug delivery is a fascinating research field. Gel-based formulations present potent characteristics as buccal systems since they have great physicochemical properties. Methods: Among the various gels, ...

• Kozmetik preparatlar ve kozmetik preparatlarda kullanılan bitkiler 

  Üstündağ Okur, Neslihan; Karadağ, Ayşe Esra; İpekçi, Esra; Bülbül, Ece (Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş., 2020)

  Bitkilerden elde edilen ekstreler ve fitokimyasallar, geçmişten günümüze farmasötik ve kozmetik alanda kullanılan preparatların içeriğinde yer almışlardır. Özellikle kozmetik preparatlarda, son za-manlarda doğal içerikli ...

• Cytotoxic sesquiterpene coumarins from the roots of heptaptera cilicica 

  Tosun, Fatma; Aytar, Erdi Can; Beutler, John A.; Wilson, Jennifer A.; Miski, Mahmut (ACG Publications, 2021)

  Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent ...

• Synthesis, characterization and antibacterial evaluation of new pyridyl-thiazole hybrids of sulfonamides 

  Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Demirayak, Şeref (Istanbul University, 2021)

  Background and Aims: Sulfonamide drugs are a very old and noted group of small molecules, and are still one of the most important antimicrobial compounds. In this study, starting from sulfonamide drugs, new original compounds ...

• Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads 

  Erdoğan Orhan, İlkay; Tosun, Fatma; Şenol Deniz, Fatma Sezer; Eren, Gökçen; Mıhoğlugil, Feyyaz; Akalgan, Demet; Miski, Mahmut (Elsevier Ltd, 2021)

  Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ...

• Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines 

  Karakaş, Nihal; Okur, Mehmet Evren; Öztunç, Nurşah; Polat, Derya Çiçek; Karadağ, Ayşe Esra (Walter de Gruyter GmbH, 2021)

  Objectives: Laurocerasus officinalis Roem. fruits are traditionally used for several health problems. Although there are some studies about its antiproliferative effects on different cancer cells, no study was reported ...

• Evaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic mice 

  Şakul, Ayşe Arzu; Kurtul, Ekin; Özbek, Hanefi; Kırmızı, Neriman İpek; Bahtiyar, Bade Cevriye; Saltan, Hayriye; Bahadır Acıkara, Özlem (Marmara University Faculty of Health Sciences, 2021)

  Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin ...

• Phthalocyanine-conjugated glyconanoparticles for chemo-photodynamic combination therapy 

  Daǧ, Aydan; Çakılkaya, Eda; Omurtag Özgen, Pınar Sinem; Atasoy, Sezen; Yiğit Erdem, Gülşah; Çetin, Büşra; Çavuş Kokuroǧlu, Aytaç; Gürek, Ayşe Gül (NLM (Medline), 2021)

  Combination cancer therapy based on multifunctional nanomaterials has attracted great attention. The present work focuses on the preparation of the glycopolymeric nanoparticle, which contains a photosensitizer (zinc(II)p ...

• In vitro anti-helicobacter pylori and antimycobacterial activity evaluation of selected plants from Turkey 

  Karadağ, Ayşe Esra; Çaşkurlu, Ayşegül; Tosun, Fatma (2020)

  In this study, the extracts of Ulmus minor Mill. subsp. minor (Ulmaceae), Lathyrus pratensis L. (Leguminosae), Glaucium leiocarpum Bois. (Papaveraceae), and Echium vulgare L. (Boraginacea) were investigated for their in ...

• Hemostatic activity of cistus creticus extract in wistar albino rats 

  Karadağ, Ayşe Esra; Çaşkurlu, Ayşegül; Okur, Mehmet Evren; Güzelmeriç, Etil; Üstündağ Okur, Neslihan; Tosun, Fatma; Yeşilada, Erdem; Demirci, Fatih (Springer Nature, 2021)

  Aerial part preparations of Cistus creticus L., Cistaceae, are traditionally used in Anatolia as a hemostatic agent. The air-dried aerial parts were extracted with methanol. Gels were prepared, followed by the hemostatic ...

• An alternative approach wound healing field with polypodium vulgare 

  Batur, Şebnem; Ayla, Şule; Şakul, Ayşe Arzu; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Özdemir, Ekrem Musa; Kepil, Nuray; Günal, Mehmet Yalçın (Logos Medical Publishing, 2020)

  Objective: In this study, we examined the effects of Polypodium vulgare L. (Polypodiaceae) as a candidate to be used for wound healing scarred area. We investigated the antibacterial, and antioxidant activity of P. Vulgare ...

• Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors 

  Şahin, Zafer; Biltekin, Sevde Nur; Bülbül, Emre Fatih; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Taylor & Francis Ltd, 2020)

  Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a-v) were evaluated in terms of their acetylcholinesterase (AChE) inhibition activities. Twenty-two compounds were tested ...

• Identification and in vitro bioactivity screening of some marine-derived fungi from Turkish coastlines 

  Heydari, Hajar; Konuklugil, Belma; Giray, Betül; Karadağ, Ayşe Esra; Güzel, Mustafa (Cahiers de Biologie Marine, 2020)

  The marine environment represents a great variety of conditions of pressure, temperature, salinity, and light depending on depth, latitude and interactions with the continental shelf. These extreme and variable conditions ...

• Matrin ve oksimatrinin mikrobiyal transformasyonu ve metabolitlerinin in vitro biyolojik aktivitelerinin incelenmesi 

  Karadağ, Ayşe Esra; Demirci, Fatih (Mersin Üniversitesi, 2020)

  Amaç: Matrin ve oksimatrin bileşiklerinin mikrobiyal transformasyon yolu ile metabolitlerin karşılaştırmalı olarak biyolojik aktivitelerinin incelenmesi hedeflenmiştir. Yöntem:30 farklı mikroorganizmanın sıvı besiyerinde ...

• HPLC-FRAP methodology and biological activities of different stem bark extracts of Cajanus cajan (L.) Millsp 

  Sinan, Kouadio Ibrahime; Mahomoodally, Mohamad Fawzi; Eyüpoğlu, Ozan Emre; Etienne, Ouattara Katinan; Sadeer, Nabeelah Bibi; Ak, Güneş; Behl, Tapan; Zengin, Gökhan (Elsevier, 2021)

  Cajanus cajan. (L.) Millsp. (C. cajan) (Family: Fabaceae) also known as pigeon pea, is a famous food and cover/forage crop bearing a high amount of key amino acids (methionine, lysine and tryptophan). This study investigated ...

• Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition 

  Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Özhan, Yağmur; Sipahi, Hande; Gao, Zhanguo; Jacobson, Kenneth A.; Demirayak, Şeref (Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)

  Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ...

• Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract 

  Okur, Mehmet Evren; Karadağ, Ayşe Esra; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Kültür, Şükran; Demirci, Betül; Demirci, Fatih (Elsevier Ireland Ltd, 2021)

  Ethnopharmacological relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. Methods: For the identification of the active fraction, the air ...

• A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma 

  Gemici, Aliihsan; Bilgen, Hülya; Erdoğan, Cem; Kansu, Abdullah; Olmuşçelik, Oktay; Beköz, Hüseyin Saffet; Dinleyici, Rümeysa; Mert, Ali; Sevindik, Ömür Gökmen (Tübitak Scientific & Technical Research Council Turkey, 2020)

  Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was ...

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