• In vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils 

  Karadağ, Ayşe Esra; Biltekin, Sevde Nur; Demirci, Betül; Demirci, Fatih (Istanbul Medipol University, 2022)

  In this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia ...

• The effect of chamomile extract on blood sugar level, lipid profile and body weight in high-fat diet fed rats 

  Barcın Güzeldere, Hatice Kübra; Büyükuslu, Nihal; İduğ, Tuğba (Istanbul Medipol University, 2022)

  The addition of herbs to the diet is one of the methods for the treatment of obesity. It is aimed to examine the extracts of chamomile to use in the treatment of obesity, against high-fat diet. In this study, 6-8 weeks old ...

• Evaluation of clinical pharmacist interventions on drug-related problems in the gastroenterology ward 

  Ceylan, Cengizhan; Sancar, Mesut; Beceren, Ayfer; Demir, Ali; Kuş, Coşkun; Omurtağ, Gülden Zehra (Marmara University, 2022)

  Integrating clinical pharmacists in a multidisciplinary patient care team improves the treatment process by identifying and resolving drug-related problems (DRPs). The aim of the study was to determine the effect of clinical ...

• Cytotoxic activity of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin 

  Tosun, Fatma; Miski, Mahmut (Istanbul Medipol University, 2022)

  Cytotoxic activities of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichlorometh-ane extract of the fruits of H. anatolica showed the ...

• Increasing the biocompatibility of graphene-based hybrid nanostructures with glycopolymer 

  Dağ, Aydan; Omurtag Özgen, Pınar Sinem; Zengin Kurt, Belma; Durmuş, Zehra (Scientific Technical Research Council Turkey-TUBITAK, 2022)

  Hybrid nanostructures decorated with glycopolymers are appropriate for biomedical applications. In this paper, the results are obtained from nanographene (NG) decorated with glycoblock copolymer to increase their potential ...

• Benzotriazole-oxadiazole hybrid compounds: Synthesis, anticancer activity, molecular docking and ADME profiling studies 

  Mermer, Arif; Bülbül, Muhammet Volkan; Kalender, Semiha Mervenur; Keskin, İlknur; Tüzün, Burak; Eyüpoğlu, Ozan Emre (Elsevier B.V., 2022)

  Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method ...

• Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors 

  Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Küçükkılınç, Tuba Tüylü; Demirayak, Şeref (Elsevier B.V., 2022)

  Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ...

• Evaluation of the in vivo preclinical toxicity of targeted nanoparticles 

  Ceylan, Cengizhan; Tatlıpιnar, Mücteba Eşref; Tüccar, Sinem; Omurtag, Gülden Zehra; Akbuğa, Fatma Jülide (Taylor and Francis, 2021)

  Drug delivery systems include nanoparticles (NPs), nanoemulsions, nanosuspensions, nanoliposomes, niosomes, dendrimers, fullerene, carbon nanotubes, nanogels, polymeric micelles, and solid lipid NPs. Although the drug-based ...

• Tilia tomentosa moench çiçeklerinin uçucu bileşenlerinin ve çeşitli in vitro biyolojik aktivitelerinin incelenmesi 

  Karakaş, Nihal; Okur, Mehmet Evren; Öztunç, Nurşah; Karadağ, Ayşe Esra; Kültür, Şükran; Demirci, Betül (2019)

  Amaç: Tilia tomentosa Moench. (Malvaceae) bitkisinin çiçeklerinden elde edilen n-hekzan ekstresinin uçucu bileşenleri, toplam fenolik madde miktarı, in vitro antioksidan, antimikrobiyal ve hücre canlılığı aktivitelerinin ...

• Fragrance component analysis for nebulvapours of European anchovy oils by using colorimetric printing and electronic nose 

  Eyüpoğlu, Ozan Emre (2019)

  Analysis of odor components about biochemicals find the widespace in the evaluation of flavor parameters and anchovies as biologicalmaterials. Food dye solutions as printer's inks were sprayed on to the fabricthroughout ...

• Evaluation of in situ gel containing pycnogenol for cutaneous wound healing 

  Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)

  Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ...

• Antioxidant activities, phenolic contents and electronic nose analysis of black garlic 

  Eyüpoğlu, Ozan Emre (2019)

  Black garlic is a processed garlic product with a moisture-controlledhigh temperature heat treatment for a long time. In order to determine thesecondary metabolites of black garlics treated in the study, firstly, in ...

• Phytochemical and in vitro pharmacological evaluation of Phlomis Pungens 

  Okur, Mehmet Evren; Karadağ, Ayşe Esra; Reis, Rengin; Sipahi, Hande; Arslan, Rana; Demirci, Betül; Demirci, Fatih (Ankara University, 2022)

  Objective: This study aimed to investigate the in vitro wound healing, anti-inflammatory, antimicrobial and antioxidant activity of Phlomis pungens Willd. extract derived from the aerial parts. Material and Method: The ...

• The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians 

  Söylemez, Esra; Özçağlı, Eren; Korkmaz, Serol; Tok, Olgu Enis; Aydın, Mehmet Şerif; Omurtag, Gülden Zehra (SAGE Publications Ltd, 2022)

  Ionizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions ...

• Extract of Glycyrrhiza glabra root attenuates nociception in experimental pain models: The role of BKCa channels 

  Parlar, Ali; Parlar Köprülü, Rabia Edibe; Arslan, Seyfullah Oktay; Çam, Saliha Ayşenur; Pesen Özdoğan, Fidan; Yumrutaş, Önder; Üçkardeş, Fatih; Rios, Miguel; Martinez, Jose L. (MS Editions, 2022)

  The aim of this study was to evaluate the functional interaction of Glycyrrhiza glabra root extract (GGRE) on the large conductance Ca2+-activated K+ (BKCa) channels expressed in the peripheral nervous system by using ...

• Determination and evaluation of acidity constants of some imidazole and thiazole linked acetamide compounds 

  Tay, Naime Funda; Duran, Murat; İspir, Cihan; Demirayak, Şeref (Anadolu University, 2016)

  In this work, the effect of substituents on the acidity constants of some acetamide derivatives was investigated. The acidity constants of nine acetamide derivatives were determined at 25 °C using a UV spectrophotometric ...

• Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles 

  Şahin, Zafer; Koçoğlu Kalkan, Melike; Berk, Barkın; Yurttaş, Leyla; Bender, Ceysu; Biltekin Kaleli, Sevde Nur; Demirayak, Şeref (Scientific Technical Research Council Turkey-Tubitak, 2021)

  Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives ...

• Effect of glabridin on microvascular permeability of plasma proteins induced by carrageenan 

  Parlar Köprülü, Rabia Edibe; Parlar, Ali; Çam, Saliha Ayşenur; Arslan, Seyfullah Oktay (Biointerface Research in Applied Chemistry, 2022)

  In present study, investigate the anti-inflammatory effects of glabridin (GLA) in the carrageenan-induced paw edema test of rats. Inflammation is an answer to the body's immune response to various stimuli such as physical ...

• In vitro ACE2 and 5-LOX enzyme inhibition by menthol and three different mint essential oils 

  Demirci, Fatih; Karadağ, Ayşe Esra; Biltekin, Sevde Nur; Demirci, Betül (SAGE Publications Inc., 2021)

  Mentha arvensis L., M. citrata L., and M. spicata L. (family Lamiaceae) essential oils, and their characteristic constituent, menthol, were evaluated in vitro for angiotensin converting enzyme 2 (ACE2) and 5-lipoxygenase ...

• Sağlık öğrencilerinde aşı tereddüdü 

  Çetin, Ali Osman; Şaşmaz, Asiye; Kurtuluş, Dilara; Badur, İsa; Balkan, İlker İnanç; Owiw, Mohannad; Öge, Ali Emre; Atak, Muhammed; Duman, Alparslan; Altunel, Ayşe Nur; Akkoyun, Meryem; Korkmaz, Beyza; Çelik, Ahmet Ali; Özdilek, Yusuf İhsan; Keleş, Huzeyfe; Az, Adem; Ankaralı, Handan (Hayat Sağlık ve Sosyal Hizmetler Vakfı, 2021)

  Amaç: Bu çalışmada İstanbul’da sağlık alanında (tıp, diş hekimliği, eczacılık, hemşirelik, ebelik, fizik tedavi ve rehabilitasyon, diyetisyenlik, odyoloji, sağlık yönetimi) yükseköğrenim görmekte olan öğrencilerin aşı ...

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