• Investigation of hidden crisis of prescription drug abuse in Turkey: Pregabalin monitoring 

  Badur, İsa; Bilgin Badur, Naciye; Berk, Barkın (Istanbul Medipol University, 2022)

  This is a cross-sectional retrospective observational national study. Abuse/misuse of the pregabalin and related parameters analyzed. Pregabalin was mostly pre-scribed by general practitioners (26.2%). Pregabalin prescribing ...

• Cytotoxic activity and docking studies of 2-arenoxybenzaldehyde N-acyl hydrazone and 1,3,4-oxadiazole derivatives against various cancer cell lines 

  Aydın, Esranur; Şentürk, Ahmet Mesut; Başpınar Küçük, Hatice; Güzel, Mustafa (MDPI, 2022)

  To understand whether previously synthesized novel hydrazone and oxadiazole derivatives have promising anticancer effects, docking studies and in vitro toxicity assays were performed on A-549, MDA-MB-231, and PC-3 cell ...

• Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation 

  Şahin, Zafer; Özhan, Yağmur; Sipahi, Hande; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)

  Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ...

• Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation 

  Arpa, Muhammet Davut; Seçen, İkbal Merve; Erim, Ümit Can; Hoş, Ayşegül; Üstündağ Okur, Neslihan (Taylor & Francis Ltd, 2022)

  In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. ...

• A novel approach in the treatment of osteoarthritis: In vitro and in vivo evaluation of Allium sativum microemulsion 

  Okur, Mehmet Evren; Kolbaşı, Bircan; Şahin, Mustafa; Karadağ, Ayşe Esra; Reis, Rengin; Çağlar, Emre Şefik; Kaplan, Arife Ahsen; Sipahi, Hande; Keskin, İlknur; Demiralp, Bahtiyar; Üstündağ Okur, Neslihan (Wiley, 2022)

  Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to ...

• Synthesis and antibacterial evaluation of novel benzimidazole, benzothiazole, benzofurane, and naphtofurane derivatives of aminothiazoles 

  Şahin, Zafer; Tok, Büşra Işıl; Akgün, Erol; Çaşkurlu, Ayşegül; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Ankara Association of Pharmaceutical Sciences, 2022)

  The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, ...

• Phytochemical compounds loaded to nanocarriers as potential therapeutic substances for alzheimer’s disease-could they be effective? 

  Polat, Derya Çiçek; Karadağ, Ayşe Esra; Parlar Köprülü, Rabia Edibe; Karantas, Ioannis D.; Mutlu, Gökçe; Çağlar, Emre Şefik; Okur, Mehmet Evren; Üstündağ Okur, Neslihan; Siafaka, Panoraia I. (Bentham Science Publishers, 2022)

  Alzheimer's disease accounts for a high percentage of dementia cases in elderly individuals. This type of brain disease is caused by damage to the brain cells affecting the ability of the patients to communicate, as well ...

• Nafion/aquivion-based composite lithium ion exchange membranes for high capacity Li-S batteries 

  Dombaycıoğlu, Şeyma; Günsel, Hilal; Aydın, Ali Osman (Wiley-VCH Verlag GmbH, 2022)

  Lithiated Nafion (Li-Naf) and lithiated Aquivion (Li-Aqu) ion exchange membranes are applied as electrolyte and separator to prevent the polysulfide shuttle effect in Li−S batteries. The production and characterization of ...

• Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives 

  Coşkun, Göknil Pelin; Şahin, Zafer; Erdoğan, Ömer; Çevik, Özge; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Ülgen, Mert; Demirayak, Şeref (Elsevier B.V., 2023)

  Chondrosarcoma is the most common cartilage sarcoma among adult patients. It is mainly observed after the degradation of chondrocytes in the case of cell stress. Unfortunately, the mortality among patients is high as a ...

• Evaluation of educational needs of diabetic patients 

  Aksoy, Nilay; Öztürk, Nur; Ulusoy, Serel; Umar, Rashida Muhammad; Özaydın, Sena (Faculty of Pharmacy of Ankara University, 2022)

  Objective: Our study aimed to assess the role of pre-graduate pharmacy students’ participation in a diabetic education program on improving diabetic self-care. Material and Method: This study included both a cross-sectional ...

• Evaluation of clinical pharmacist interventions on drugrelated problems in the gastroenterology ward 

  Ceylan, Cengizhan; Sancar, Mesut; Beceren, Ayfer; Demir, Ali; Kuş, Coşkun; Omurtag, Gülden Zehra (Marmara University, 2022)

  Integrating clinical pharmacists in a multidisciplinary patient care team improves the treatment process by identifying and resolving drug-related problems (DRPs). The aim of the study was to determine the effect of clinical ...

• Determination of mycotoxins by HPLC, LC-MS/MS and health risk assessment of the mycotoxins in bee products of Turkey 

  Keskin, Eda; Eyüpoğlu, Ozan Emre (NLM (Medline), 2023)

  The aim of this study is to determine the levels of deoxynivalenol (DON), HT-2 toxin (HT2), T-2 toxin (T2), and ochratoxin A (OTA) in bee products (bee pollen, propolis, honey and royal jelly) available in Turkey. In ...

• Potent colon cancer cell line toxicity of the fruit extracts of Heptaptera triquetra (Vent.) Tutin 

  Tosun, Fatma; Miski, Mahmut (Istanbul Medipol University, 2022)

  Cytotoxic activities of the fruit extracts of Heptaptera triquetra (Vent.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the fruits of H. triquetra showed the highest ...

• Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives 

  Tay, Naime Funda; Duran, Murat; Kayagil, İsmail; Yurttaş, Leyla; Göger, Gamze; Göğer, Fatih; Demirci, Fatih; Demirayak, Şeref (Universidade de São Paulo, 2022)

  In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity ...

• Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes 

  Şalva, Emine; Alan, Saadet; Karakoyun, Berna; Çakalağaoğlu, Fulya; Özbaş, Suna; Akbuğa, Jülide (Universidade de São Paulo, 2022)

  Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing ...

• Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey 

  Omurtag Özgen, Pınar Sinem; Biltekin, Sevde Nur; İduğ, Tuğba; Macit, Çağlar; Ayran, İrem; Çelik, Sadiye Ayşe; Kültür, Şükran; Kan, Yüksel; Omurtag, Gülden Zehra (Marmara University, 2022)

  The essential oil obtained from Lavandula angustifolia Mill. (Lavander) has many pharmacological effects, including antioxidant, antifungal, antibacterial and carminative effects. Lavandula angustifolia essential oil (LEO) ...

• Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives 

  Kandemir, Levent; Karakuş, Sevgi; Özbaş, Suna; Rollas, Sevim; Akbuğa, Julide (Marmara University, 2022)

  In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide ...

• In vitro and in silico evaluation of ACE2 and LOX inhibitory activity of eucalyptus essential oils, 1,8-cineole, and citronellal 

  Ak Sakallı, Ezgi; Teralı, Kerem; Karadağ, Ayşe Esra; Biltekin, Sevde Nur; Koşar, Müberra; Demirci, Betül; Başer, Kemal Hüsnü Can; Demirci, Fatih (SAGE Publications Inc., 2022)

  Eucalyptus essential oils are well-known and used especially in upper respiratory tract pathologies or diseases as herbal drug preparations. In the present study, the in vitro angiotensin-converting enzyme 2 (ACE2) and ...

• Administration of Ad5/chitosan/PEG-aptamer vector delivering PDGF-D shRNA decreases tumor growth in rat breast cancer model 

  Ekentok Atıcı, Ceyda; Akbuğa, Fatma Jülide (Mary Ann Liebert, 2021)

  ...

• In vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils 

  Karadağ, Ayşe Esra; Biltekin, Sevde Nur; Demirci, Betül; Demirci, Fatih (Istanbul Medipol University, 2022)

  In this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia ...

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