Formulation of microemulsions for dermal delivery of Cephalexin
Künye
Üstündağ Okur, N., Er, S., Çağlar, E. Ş., Ekmen, T. Z. ve Sala, F. (2017). Formulation of microemulsions for dermal delivery of Cephalexin. Acta Pharmaceutica Sciencia, 55(4), 27-40. https://dx.doi.org/10.23893/1307-2080.APS.05524Özet
Introduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery of drugs. Objective: The objective of the present study was to prepare novel CEM loaded microemulsions and to characterize formulations, to evaluate their in vitro release profiles and antibacterial activities. Method: CEM loaded formulations [0.02% (w/w)] were characterized according to their droplet size, zeta potential, PDI, pH, electrical conductivity and viscosity. In addition, in vitro drug release studies and antibacterial activity tests were performed. Results: The developed CEM loaded microemulsions (M1 and M2) achieved narrow droplet size distribution (152.75±4.85 and 128.05±9.22), low PDI (0.364±0.05 and 0.489±0.06), suitable pH (5.28-4.84) and conductivity (342±4.472-374±5.477 µS/cm). Zeta potential was measured as 0.209±0.041 and 0.141±0.024 mV. M1CEM showed 100% release at the 7th hour and was provided almost the same zone diameter as CEM solution when evaluated for antibacterial activity. Conclusion: Overall, it was concluded that microemulsions might be beneficial in improving dermal delivery of CEM for the treatment of skin and soft tissue infections.
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Acta Pharmaceutica ScienciaCilt
55Sayı
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