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dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorEr, Sevda
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorEkmen, Tarık Ziya
dc.contributor.authorSala, Furkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:13Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:13Z
dc.date.issued2017en_US
dc.identifier.citationÜstündağ Okur, N., Er, S., Çağlar, E. Ş., Ekmen, T. Z. ve Sala, F. (2017). Formulation of microemulsions for dermal delivery of Cephalexin. Acta Pharmaceutica Sciencia, 55(4), 27-40. https://dx.doi.org/10.23893/1307-2080.APS.05524en_Us
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1097
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05524
dc.description.abstractIntroduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery of drugs. Objective: The objective of the present study was to prepare novel CEM loaded microemulsions and to characterize formulations, to evaluate their in vitro release profiles and antibacterial activities. Method: CEM loaded formulations [0.02% (w/w)] were characterized according to their droplet size, zeta potential, PDI, pH, electrical conductivity and viscosity. In addition, in vitro drug release studies and antibacterial activity tests were performed. Results: The developed CEM loaded microemulsions (M1 and M2) achieved narrow droplet size distribution (152.75±4.85 and 128.05±9.22), low PDI (0.364±0.05 and 0.489±0.06), suitable pH (5.28-4.84) and conductivity (342±4.472-374±5.477 µS/cm). Zeta potential was measured as 0.209±0.041 and 0.141±0.024 mV. M1CEM showed 100% release at the 7th hour and was provided almost the same zone diameter as CEM solution when evaluated for antibacterial activity. Conclusion: Overall, it was concluded that microemulsions might be beneficial in improving dermal delivery of CEM for the treatment of skin and soft tissue infections.en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterial Activityen_US
dc.subjectCephalexinen_US
dc.subjectDermal Deliveryen_US
dc.subjectIn Vitro Releaseen_US
dc.subjectMicroemulsionen_US
dc.titleFormulation of microemulsions for dermal delivery of Cephalexinen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-3210-3747en_US
dc.authorid0000-0003-2010-4918en_US
dc.identifier.volume55en_US
dc.identifier.issue4en_US
dc.identifier.startpage27en_US
dc.identifier.endpage40en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.05524en_US


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