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New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test

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Date

2020

Author

Arpa, Muhammet Davut
Yoltaş, Ayşegül
Onay Tarlan, Ecehan
Şahin Şenyüz, Cemre
Sipahi, Hande
Aydın, Ahmet
Üstündağ Okur, Neslihan

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Arpa, M. D., Yoltaş, A., Onay Tarlan, E., Şahin Şenyüz, C., Sipahi, H., Aydın, A. ... Üstündağ Okur, N. (2020). New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test. Pharmaceutical Development and Technology, 25(10), 1238-1248. https://dx.doi.org/10.1080/10837450.2020.1809457

Abstract

The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent gynecological disorders. Various antifungal drugs are used for its treatment, with Terbinafine being one of them. In this study, new gel formulations were prepared for Terbinafine vaginal delivery. Natural polymers such as chitosan, sodium carboxymethylcellulose, and Carbopol were used for the development of Terbinafine vaginal gels. The developed gels were examined for their viscosity and spreadability, pH and mechanical properties. The most optimal formulations were further evaluated for theirin vitrorelease behavior and antifungal activities. In further, the cytotoxicity and irritation inducing capacity of optimum gel formulations were evaluated.In vitrodrug release studies demonstrated that terbinafine release was prolonged whereas anti-candida activity in several species showed the superiority of the gels compared to the marketed product. G-5 and G-8 gels did not cause lysis, hemorrhage and coagulation, therefore, classified as non-irritant. The optimal formulations were also studied for their stability, demonstrating that they were stable for 3 months.

WoS Q Kategorisi

Q3

Source

Pharmaceutical Development and Technology

Volume

25

Issue

10

URI

https://dx.doi.org/10.1080/10837450.2020.1809457
https://hdl.handle.net/20.500.12511/6065

Collections

  • Makale Koleksiyonu [250]
  • PubMed İndeksli Yayınlar Koleksiyonu [3764]
  • Scopus İndeksli Yayınlar Koleksiyonu [5808]
  • WoS İndeksli Yayınlar Koleksiyonu [5978]



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