In vitro ACE2 and 5-LOX inhibition of rosmarinus officinalis l. essential oil and its major component 1,8-cineole

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dc.authorid0000-0002-3412-0807
dc.authorid0000-0003-1896-2729
dc.contributor.authorDemirci, Fatih
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorDemirci, Betül
dc.date.accessioned2021-09-16T08:15:21Z
dc.date.available2021-09-16T08:15:21Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIn this present study, Rosmarinus officinalis L. essential oil, and its major component 1,8-cineole was evaluated in vitro for angiotensin converting enzyme 2 (ACE2), as well as for 5-lipoxygenase (5-LOX) enzyme inhibitory activity. The essential oil composition was confirmed both by GC-FID and GC/MS, where 1,8-cineole (62.7%), alpha-pinene (12.6 %), and camphor (8.3 %) were identified as the main constituents. Activity studies were performed at concentrations of 20 mu g/mL for essential oil, and 5 mu g/mL for the major compound 1,8-cineole, which were compared experimentally with standards. The essential oil was evaluated using a fluorometric multiplate based enzyme inhibition kit, where the ACE2 inhibition of Rosmarinus aetheroleum was 20%, while the 5-LOX inhibition was observed as 81.1%, respectively. In addition, the major constituent 1,8-cineole also showed remarkable ACE2 inhibition with 89.2%, and 5-LOX inhibition with 37.2%, respectively. As a result, the cineole chemotype rosemary essential oil, and its major constituent 1,8-cineol may have antiviral potential applications against coronaviruses due to ACE2 enzyme inhibition with anti-inflammatory effects. Further in vivo studies are needed to confirm the efficacy of essential oils and their constituents.
dc.description.sponsorshipAnadolu Universityen_US
dc.identifier.citationDemirci, F., Karadağ, A. E., Biltekin, S. N. ve Demirci, B. (2022). In vitro ACE2 and 5-LOX inhibition of rosmarinus officinalis l. essential oil and its major component 1,8-cineole. Records of Natural Products, 16(2), 194-199. https://dx.doi.org/10.25135/rnp.265.21.05.2080
dc.identifier.doi10.25135/rnp.265.21.05.2080
dc.identifier.endpage199
dc.identifier.issn1307-6167
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage194
dc.identifier.trdizinid523943
dc.identifier.urihttps://dx.doi.org/10.25135/rnp.265.21.05.2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8189
dc.identifier.volume16
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherACG Publications
dc.relation.ispartofRecords of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRosmarinus Officinalis L.
dc.subjectEssential Oil
dc.subjectACE2
dc.subject5-LOX
dc.subject1,8-Cineole
dc.titleIn vitro ACE2 and 5-LOX inhibition of rosmarinus officinalis l. essential oil and its major component 1,8-cineole
dc.typeArticle

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