Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives
| dc.authorid | 0000-0002-1693-9579 | |
| dc.contributor.author | Kandemir, Levent | |
| dc.contributor.author | Karakuş, Sevgi | |
| dc.contributor.author | Özbaş, Suna | |
| dc.contributor.author | Rollas, Sevim | |
| dc.contributor.author | Akbuğa, Julide | |
| dc.date.accessioned | 2022-07-25T12:16:40Z | |
| dc.date.available | 2022-07-25T12:16:40Z | |
| dc.date.issued | 2022 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı | |
| dc.description.abstract | In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide derivatives (1a-9a). The structures of the synthesized compounds were confirmed by the data obtained from elemental analysis, HPLC, UV, IR,1H-NMR and MS spectra. All of the compounds were tested for their cytotoxic activities against L929 fibroblast cells by MTT method. It was determined that the tested compounds 1a-9a, 1b-9b and 1c-9c were not cytotoxic at the studied concentrations (5.0 µg/mL and 10.0 µg/mL) in L929 cell lines. Compounds 1a-c, 2a-c, 3a-c, 4a-c, 5a-c and 8a-c showed increased growth inhibition whereas compounds 6a-c, 7a-c and 9a-c showed decreased growth inhibition on L929 cell lines. | |
| dc.identifier.citation | Kandemir, L., Karakuş, S., Özbaş, S., Rollas, S. ve Akbuğa, J. (2022). Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives. Journal of Research in Pharmacy, 26(4), 941-953. http://doi.org/10.29228/jrp.192 | |
| dc.identifier.doi | 10.29228/jrp.192 | |
| dc.identifier.endpage | 953 | |
| dc.identifier.issn | 2630-6344 | |
| dc.identifier.issue | 4 | |
| dc.identifier.scopus | 2-s2.0-85133904069 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 941 | |
| dc.identifier.trdizinid | 535934 | |
| dc.identifier.uri | http://doi.org/10.29228/jrp.192 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/9605 | |
| dc.identifier.volume | 26 | |
| dc.identifier.wos | 000836312200022 | en_US |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.institutionauthor | Akbuğa, Julide | |
| dc.language.iso | en | |
| dc.publisher | Marmara University | |
| dc.relation.ispartof | Journal of Research in Pharmacy | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Acid Hydrazide | |
| dc.subject | Cytotoxicity | |
| dc.subject | 1,3,4-Thiadiazole | |
| dc.subject | 1,4-Disubstituted Thiosemicarbazide | |
| dc.subject | 1,2,4-Triazole-3- Thione | |
| dc.title | Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives | |
| dc.type | Article |
