Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films

Arpa, Muhammet Davut; Ünükür, Melike Zeynep; Erim, Ümit Can

Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films

dc.authorid	0000-0001-9290-2404
dc.authorid	0000-0003-1422-8359
dc.authorid	0000-0002-4121-588X
dc.contributor.author	Arpa, Muhammet Davut
dc.contributor.author	Ünükür, Melike Zeynep
dc.contributor.author	Erim, Ümit Can
dc.date.accessioned	2021-10-08T08:25:07Z
dc.date.available	2021-10-08T08:25:07Z
dc.date.issued	2021
dc.department	İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstract	Buccal administration of different active ingredients as an alternative to oral or dermal routes has been widely studied. The films are one of the most investigated dosage forms regarding the buccal formulations developed using bioadhesive polymers. Having thin and flexible structures, the films remain in the mouth for their duration of action without causing any discomfort. There are many studies conducted to develop buccal films for local treatment of oral fungal infections. In this research, buccal films were prepared using terbinafine hydrochloride, which is frequently used orally and systemically in the treatment of fungal infections and has low water solubility. The films were prepared by solvent casting method using hydroxypropyl methyl cellulose (HPMC) and polyvinyl pyrrolidone K30 (PVP) as the bioadhesive polymers and glycerin (2-3%) as the plasticizer. Characterization properties including thickness, weight uniformity, flexibility, tensile strength, swelling capacity were examined and the bioadhesive characteristics were determined by Texture Analyzer device using bovine buccal tissue. According to the findings of bioadhesion studies, the highest bioadhesive properties were detected in F1 and F7 formulations, which contained 5% HPMC. In vitro release studies exhibited that F1 and F7 film formulations with 5% HPMC represented slower and more controlled release compared to F2 and F8 film formulations having 4% HPMC + 1% PVP. The results revealed that the developed buccal formulations loaded with terbinafine hydrochloride might be convenient for the local treatment of oral fungal infections.
dc.identifier.citation	Arpa, M. D., Ünükür, M. Z. ve Erim, Ü. C. (2021). Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. Journal of Research in Pharmacy, 25(5), 667-680. https://dx.doi.org/10.29228/jrp.58
dc.identifier.doi	10.29228/jrp.58
dc.identifier.endpage	680
dc.identifier.issn	2630-6344
dc.identifier.issue	5
dc.identifier.scopusquality	Q3
dc.identifier.startpage	667
dc.identifier.trdizinid	489701
dc.identifier.uri	https://dx.doi.org/10.29228/jrp.58
dc.identifier.uri	https://hdl.handle.net/20.500.12511/8394
dc.identifier.volume	25
dc.identifier.wosquality	N/A
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	TR-Dizin
dc.language.iso	en
dc.publisher	Marmara University
dc.relation.ispartof	Journal of Research in Pharmacy	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Terbinafine Hydrochloride
dc.subject	Hydroxypropyl Methylcellulose
dc.subject	Polyvinylpyrrolidone
dc.subject	Buccal Drug Delivery
dc.subject	Buccal Film
dc.title	Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films
dc.type	Article