Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment

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dc.authorid0000-0003-2010-4918
dc.authorid0000-0001-6739-2094
dc.authorid0000-0003-2143-5268
dc.contributor.authorÜstünda? Okur, Neslihan
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorPekcan, Ahmet Nezihi
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.date.accessioned2020-02-27T08:58:29Z
dc.date.available2020-02-27T08:58:29Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Klinik Eczacılık Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the study is to evaluate the strengthening of penetration of the epidermis through the formulas containing hydroquinone in melasma treatment and development of alternative new carrier systems. During preparation of hydroquinone loaded microemulsions, isopropyl myristate (IPM) as oil phase, Cremophor EL, Span 20, Span 80 and Tween 20 as surfactant, ethanol as co-surfactant, distilled water as aqueous phase were used. Furthermore, in vitro drug release studies were performed. As results of the study, it was measured that conductivity between 16 ± 2.51 and 42.1 ± 2.67, viscosity between 8.97 ± 0.082 and 51.76 ± 0.04, pH between 3.3 ± 0.436 and 5.7 ± 0.2 and refractive index between 1.4032 ± 0.0002 and 1.4299 ± 0.0002. Formulations showed that zeta potential between-0.461 ± 0.009 and 0.359 ± 0.223, PDI between 0.08 ± 0.02 and 0.196 ± 0.067, and droplet size between 24.27 ± 3.559 and 324.9 ± 16.8 nm. Moreover, in vitro drug release studies showed that formulation M2 released 87.405 % of the drug at the end of the 24h. According to results of histopathological analysis, formulations were found convenient for the usage. According to results of our study, hydroquinone loaded microemulsions can be seen as a promising alternative for the treatment of melasma disease.
dc.identifier.citationÜstünda? Okur, N., Çağlar, E. Ş., Pekcan, A. N., Okur, M. E. ve Ayla, Ş. (2019). Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment. Journal of Research in Pharmacy, 23(4), 662-670. http://doi.org/10.12991/jrp.2019.174
dc.identifier.doi10.12991/jrp.2019.174
dc.identifier.endpage670
dc.identifier.issn2630-6344
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage662
dc.identifier.urihttp://doi.org/10.12991/jrp.2019.174
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4967
dc.identifier.volume23
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydroquinone
dc.subjectMelasma
dc.subjectMicroemulsion
dc.subjectTopical
dc.subjectMice
dc.subjectSkin Irritation
dc.titlePreparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment
dc.typeArticle

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