Cytotoxicity screening of some Turkish plants against renal cancer cells

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dc.authorid0000-0003-2533-5141
dc.contributor.authorMihoğlugil, Feyyaz
dc.contributor.authorAkalgan, Demet
dc.contributor.authorTosun, Fatma
dc.date.accessioned2023-04-18T07:50:51Z
dc.date.available2023-04-18T07:50:51Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description.abstractIn this contribution, we performed cytotoxicity screening of 51 extracts from 17 plant species, representing 14 families growing in Turkey. Cytotoxic activities of the dichloromethane, ethyl acetate, and methanol extracts of the plants were investigated against the renal (A498 and U031) cancer cell lines. 28 extracts exhibited more than 50% growth inhibition at a 25 ug/mL concentration on both renal cancer A498 and UO31 cell lines. The extracts showed higher activity against UO31 cells than A498 cells. The dichloromethane extract of the aerial parts of Scabiosa columbaria ssp. columbaria showed the highest cytotoxic activity with 64% inhibition at a 25 ug/mL concentration on the renal cancer UO31 cell line. The methanol extract of the aerial parts of Epilobium minutiflorum showed the highest cytotoxic activity with 63% inhibition at a 25 ug/mL concentration on the renal cancer A498 cell line.
dc.identifier.citationMihoğlugil, F., Akalgan, D. ve Tosun, F. (2023). Cytotoxicity screening of some Turkish plants against renal cancer cells. Journal of Research in Pharmacy, 27(2), 636-641. https://dx.doi.org/10.29228/jrp.346
dc.identifier.doi10.29228/jrp.346
dc.identifier.endpage641
dc.identifier.issn2630-6344
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85151358720
dc.identifier.scopusqualityQ3
dc.identifier.startpage636
dc.identifier.trdizinid1177566
dc.identifier.urihttps://dx.doi.org/10.29228/jrp.346
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10877
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorTosun, Fatma
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytotoxic Activity
dc.subjectRenal Cancer
dc.subjectTurkish Plants
dc.subjectScabiosa Columbaria Ssp. Columbaria
dc.titleCytotoxicity screening of some Turkish plants against renal cancer cells
dc.typeArticle

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