The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice

Özçiçek, İlyas; Çakıcı, Çağrı; Ayşit, Neşe; Erim, Ümit Can

The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice

dc.authorid	0000-0002-4495-7395
dc.authorid	0000-0002-8662-5284
dc.authorid	0000-0002-4243-9092
dc.authorid	0000-0002-4121-588X
dc.contributor.author	Özçiçek, İlyas
dc.contributor.author	Çakıcı, Çağrı
dc.contributor.author	Ayşit, Neşe
dc.contributor.author	Erim, Ümit Can
dc.date.accessioned	2023-06-14T09:51:09Z
dc.date.available	2023-06-14T09:51:09Z
dc.date.issued	2023
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstract	Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production of stable and monodisperse polyethyleneimine (PEI) and polyethylene glycol (PEG) coated gold nanoparticles (AuNP20 and AuNP50), investigation of their in vivo biochemical effects in the BALB/c mice. Methods: Gold nanoparticles were synthesized and their surfaces were modified by PEI and PEG. All the necessary physicochemical characterizations were performed. After the single high dose i.v. injection (5 mg Au/kg animal weight) of the AuNP groups, their in vivo biochemical effects were evaluated multiparametrically in the mice on day 14. Results: Highly monodisperse and stable AuNPs were synthesized successfully. Significant changes in the biochemical hemogram parameters were observed depending on the surface coatings of the AuNPs. PEI and PEG surface coatings increased biocompatibility. No excessive oxidative stress response was observed in all the gold nanoparticle groups. Conclusions: It has been concluded that the surface chemistry of the particles is a more decisive parameter than the size in terms of in vivo biochemical toxicity. The surface functionalization, stability and biocompatibility of the AuNPs are important parameters for the potential biomedical applications of gold nanoparticles in future studies.
dc.identifier.citation	Özçiçek, İ., Çakıcı, Ç., Ayşit, N. ve Erim, Ü. C. (2023). The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice. The European Research Journal, 9(1), 131-139. https://doi.org/10.18621/eurj.998503
dc.identifier.doi	10.18621/eurj.998503
dc.identifier.endpage	139
dc.identifier.issn	2149-3189
dc.identifier.issue	1
dc.identifier.startpage	131
dc.identifier.trdizinid	1151017
dc.identifier.uri	https://doi.org/10.18621/eurj.998503
dc.identifier.uri	https://hdl.handle.net/20.500.12511/11087
dc.identifier.volume	9
dc.indekslendigikaynak	TR-Dizin
dc.institutionauthor	Özçiçek, İlyas
dc.institutionauthor	Çakıcı, Çağrı
dc.institutionauthor	Ayşit, Neşe
dc.institutionauthor	Erim, Ümit Can
dc.language.iso	en
dc.publisher	Prusa Medical Publishing
dc.relation.ispartof	The European Research Journal	en_US
dc.relation.publicationcategory	Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Gold Nanoparticle
dc.subject	Hemogram
dc.subject	Nanotoxicity
dc.subject	Oxidative Stress
dc.subject	PEI/PEG Surface Coatings
dc.title	The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice
dc.type	Article