In vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract

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dc.authorid0000-0002-9354-0000
dc.authorid0000-0002-3412-0807
dc.authorid0000-0002-8302-1127
dc.authorid0000-0002-2737-0568
dc.authorid0000-0001-9416-7757
dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorAyla, Şule
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorDaylan, Benay
dc.contributor.authorGüzel, Elif
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorGünal, Mehmet Yalçın
dc.date.accessioned2023-06-16T07:30:36Z
dc.date.available2023-06-16T07:30:36Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)
dc.description.abstractCarduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Turkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the genus Carduus is limited which remarks the significance of the current study. This study aims to investigate the antibacterial, antioxidant, and wound-healing properties of the methanolic extract of Carduus adpressus. Extract was obtained by maceration. The broth microdilution assay was performed on Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli. DPPH and ABTS radical scavenging assays were performed to detect the antioxidant capacity. Wound-healing activity was tested using alloxan-induced diabetic BALB-c mice. 4 groups, control, vehicle, CAE and Carduus adpressus groups were treated with the relative agent for 10 days. Extract demonstrated 62.5 mu g/mL MIC against S. aureus and E. faecalis, and 125 mu g/mL MIC against P. aeruginosa and E. coli. ABTS assay showed higher antioxidant activity compared to the DPPH assay. Carduus adpressus group demonstrated strong regeneration, epithelisation, and angiogenesis compared to the control group on day 10. Additionally, expression of PDGF, VEGF, and collagen formation was increased in the Carduus adpressus group compared to the control group on day 10. Extract demonstrated strong antibacterial, antioxidant, and wound-healing activities which indicate that it could be a source in developing wound-healing agents.
dc.identifier.citationŞakul, A. A., Ayla, Ş., Okur, M. E., Karadağ, A. E., Daylan, B., Güzel, E. ... Günal, M. Y. (2023). In vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract. Journal of Research in Pharmacy, 27(2), 665-676. https://doi.org/10.29228/jrp.349
dc.identifier.doi10.29228/jrp.349
dc.identifier.endpage676
dc.identifier.issn2630-6344
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85151389912
dc.identifier.scopusqualityQ3
dc.identifier.startpage665
dc.identifier.trdizinid1177583
dc.identifier.urihttps://doi.org/10.29228/jrp.349
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11096
dc.identifier.volume27
dc.identifier.wos000990531300007en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorŞakul, Ayşe Arzu
dc.institutionauthorKaradağ, Ayşe Esra
dc.institutionauthorDaylan, Benay
dc.institutionauthorGüzel, Elif
dc.institutionauthorÖzdemir, Ekrem Musa
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibacterial
dc.subjectAntioxidant
dc.subjectCarduus Adpressus
dc.subjectExtract
dc.subjectBALB-c Mice
dc.subjectWound-Healing
dc.titleIn vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract
dc.typeArticle

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