Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke

Kılıç, Ertuğrul; Ça?layan, Berrak; Beker, Mustafa Çağlar

Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke

dc.authorid	0000-0001-6494-8923
dc.authorid	0000-0002-5072-132X
dc.authorid	0000-0002-9476-8488
dc.contributor.author	Kılıç, Ertuğrul
dc.contributor.author	Ça?layan, Berrak
dc.contributor.author	Beker, Mustafa Çağlar
dc.date.accessioned	2020-12-30T08:41:53Z
dc.date.available	2020-12-30T08:41:53Z
dc.date.issued	2020
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstract	Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its small size and lipophilic structure. Its cytoprotective activity has been linked to its potent free radical scavenger activity with the desirable characteristics of a clinically- reliable antioxidant. Melatonin detoxifies oxygen and nitrogen-based free radicals and oxidizing agents, including the highly toxic hydroxyl-and peroxynitrite radicals, initiating cellular damage. However, the cytoprotective activity of melatonin is complex and cannot be solely limited to its free radical scavenger activity. It regulates cellular signaling pathways through receptor– dependent and independent mechanisms. Most of these downstream molecules, such as PI3K/AKT pathway components, also contribute to the cytoprotective effects of melatonin. In this term, melatonin is a promising molecule for the treatment of neurodegenerative disorders, such as ischemic stroke, which melatonin reduces ischemic brain injury in animal models of ischemic stroke. It regulates also circadian rhythm proteins after ischemic stroke, playing roles in cellular survival. In this context, present article summarizes the possible role of melatonin in the pathophysiological events after ischemic stroke.
dc.identifier.citation	Kılıç, E., Ça?layan, B. ve Beker, M. Ç. (2020). Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke. Turkish Journal of Medical Sciences, 50(SI-2), 1655-1664. https://dx.doi.org/10.3906/sag-2008-32
dc.identifier.doi	10.3906/sag-2008-32
dc.identifier.endpage	1664
dc.identifier.issn	1303-6165
dc.identifier.issn	1300-0144
dc.identifier.issue	SI-2
dc.identifier.scopusquality	Q3
dc.identifier.startpage	1655
dc.identifier.uri	https://dx.doi.org/10.3906/sag-2008-32
dc.identifier.uri	https://hdl.handle.net/20.500.12511/6171
dc.identifier.volume	50
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	NLM (Medline)
dc.relation.ispartof	Turkish Journal of Medical Sciences	en_US
dc.relation.publicationcategory	Diğer
dc.rights	Attribution 4.0 International	*
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject	Ischemic Stroke
dc.subject	Melatonin
dc.subject	Free Radicals
dc.subject	Apoptosis
dc.subject	Signaling
dc.subject	Circadian Rhythm Proteins
dc.title	Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke
dc.type	Review Article