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Öğe Hunting glioblastoma recurrence: glioma stem cells as retrospective targets(2025) Mengüç Emir, Sümeyra; Karaoğlan, Birnur Sinem; Kaşmer, Ramazan; Şirin, Hilal Buse; Sarıyıldız, Batuhan; Karakaş, NihalGlioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain malignancies in adults. Standard approaches, including surgical resection followed by adjuvant radio- and chemotherapy with temozolomide (TMZ), provide only transient control, as GBM frequently recurs due to its infiltrative nature and the presence of therapy-resistant subpopulations such as glioma stem cells (GSCs). GSCs, with their quiescent state and robust resistance mechanisms, evade conventional therapies, contributing significantly to relapse. Consequently, current treatment methods for GBM face significant limitations in effectively targeting GSCs. In this review, we emphasize the relationship between GBM recurrence and GSCs, discuss the current limitations, and provide future perspectives to overwhelm the challenges associated with targeting GSCs. Eliminating GSCs may suppress recurrence, achieve durable responses, and improve therapeutic outcomes for patients with GBM.Öğe Bridging theory and practice: how adult learning theories shape interactive lectures(2024) Baig, Mukhtiar; Tariq, Saba; Tariq, Sundus...Öğe Editorial: women in brain health and clinical neuroscience volume ıı: 2023(2024) Aktürk, Tuba; Yener, Görsev...Öğe Immune-dysregulation harnessing in myeloid neoplasms(2024) Sharifi, Mohammad Jafar; Xu, Ling; Nasiri, Nahid; Ashja Arvan, Mehnoosh; Soleimanzadeh, Hadis; Ganjalikhani Hakemi, MazdakMyeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in bone marrow microenvironments. Complex interactions emerge between normal immune system elements and leukemic clones in the bone marrow. In recent years, researchers have identified several of these pathological interactions. For instance, recent works shows that the secretion of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), from bone marrow stromal cells contributes to immune dysregulation and the selective proliferation of JAK2V617F+ clones in myeloproliferative neoplasms. Moreover, inflammasome activation and sterile inflammation result in inflamed microenvironments and the development of myelodysplastic syndromes. Additional immune dysregulations, such as exhaustion of T and NK cells, an increase in regulatory T cells, and impairments in antigen presentation are common findings in myeloid malignancies. In this review, we discuss the role of altered bone marrow microenvironments in the induction of immune dysregulations that accompany myeloid malignancies. We also consider both current and novel therapeutic strategies to restore normal immune system function in the context of myeloid malignancies.Öğe Telehealth: A bridge divided? Bridging the digital divide for equitable healthcare access(2024) Tariq, Sundus; Zaqout, Abdalrahman; Tariq, SabaTelehealth, which is the use of telecommunications technology in health care delivery according to the Health Resources and Services Administration, is also a subset of e-health. Telehealth, which provides medical assistance to remote patients, is performed through a variety of different actions and services which include interactions between patients and healthcare providers happening through the phone, e-mails, video calls, the web, remote devices, as well as short message services (SMS).Öğe Parallel electrophysiological abnormalities due to covid-19 infection and to alzheimer's disease and related dementia(2024) Jiang, Yang; Neal, Jennifer; Sompol, Pradoldej; Yener, Görsev; Arakaki, Xianghong; Norris, Christopher M.; Güntekin, Bahar; Hajós, MihályMany coronavirus disease 2019 (COVID-19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting “brain fog” and mild cognitive impairments even months after the acute phase of infection. Resting-state EEG abnormalities include EEG slowing (reduced alpha rhythm; increased slow waves) and epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that cognitive deficits due to COVID-19 and to Alzheimer's disease and related dementia (ADRD) are driven by overlapping pathologies and neurophysiological abnormalities. EEG abnormalities seen in COVID-19 patients resemble those observed in early stages of neurodegenerative diseases, particularly ADRD. It is proposed that similar EEG abnormalities in Long COVID and ADRD are due to parallel neuroinflammation, astrocyte reactivity, hypoxia, and neurovascular injury. These neurophysiological abnormalities underpinning cognitive decline in COVID-19 can be detected by routine EEG exams. Future research will explore the value of EEG monitoring of COVID-19 patients for predicting long-term outcomes and monitoring efficacy of therapeutic interventions. Highlights: Abnormal intrinsic electrophysiological brain activity, such as slowing of EEG, reduced alpha wave, and epileptiform are characteristic findings in COVID-19 patients. EEG abnormalities have the potential as neural biomarkers to identify neurological complications at the early stage of the disease, to assist clinical assessment, and to assess cognitive decline risk in Long COVID patients. Similar slowing of intrinsic brain activity to that of COVID-19 patients is typically seen in patients with mild cognitive impairments, ADRD. Evidence presented supports the idea that cognitive deficits in Long COVID and ADRD are driven by overlapping neurophysiological abnormalities resulting, at least in part, from neuroinflammatory mechanisms and astrocyte reactivity. Identifying common biological mechanisms in Long COVID-19 and ADRD can highlight critical pathologies underlying brain disorders and cognitive decline. It elucidates research questions regarding cognitive EEG and mild cognitive impairment in Long COVID that have not yet been adequately investigated.Öğe Editorial: Excessive internet use and its impact on mental health(2024) Višnjić, Aleksandar; Kök, Kıvanç; Terzić Šupić, Zorica; Stanković, MiodragThe various forms of Internet use, including social networking, online shopping, gambling, and gaming are products of the time in which we live and represent an integral part of how we conduct and engage in social interaction. Internet platforms not only facilitate daily connection and efficient exchange of important information, but also provide educational functions and raise awareness of problems faced by individuals and societies globally. However, excessive use of Internet-related content has also increasingly been linked with mental health issues and aspects, such as addictive behavior, which is a central theme of this Research Topic.Öğe From infancy to childhood: a comprehensive review of event and task related brain oscillations(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Ünsal, Esra; Duygun, Rümeysa; Yemeniciler, İrem; Bingöl, Elifnur; Ceran, Ömer; Güntekin, BaharBrain development from infancy through childhood involves complex structural and functional changes influenced by both internal and external factors. This review provides a comprehensive analysis of event and task-related brain oscillations, focusing on developmental changes across different frequency bands, including delta, theta, alpha, beta, and gamma. Electroencephalography (EEG) studies highlight that these oscillations serve as functional building blocks for sensory and cognitive processes, with significant variations observed across different developmental stages. Delta oscillations, primarily associated with deep sleep and early cognitive demands, gradually diminish as children age. Theta rhythms, crucial for attention and memory, display a distinct pattern in early childhood, evolving with cognitive maturation. Alpha oscillations, reflecting thalamocortical interactions and cognitive performance, increase in complexity with age. Beta rhythms, linked to active thinking and problem-solving, show developmental differences in motor and cognitive tasks. Gamma oscillations, associated with higher cognitive functions, exhibit notable changes in response to sensory stimuli and cognitive tasks. This review underscores the importance of understanding oscillatory dynamics to elucidate brain development and its implications for sensory and cognitive processing in childhood. The findings provide a foundation for future research on developmental neuroscience and potential clinical applications.Öğe Correction to: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations(2024) Moguilner, Sebastian; Baez, Sandra; Hernandez, Hernan; Migeot, Joaquín; Legaz, Agustina; Güntekin, Bahar; Yırıkoğulları, Harun; Bruno, Martín A....Öğe "The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder" ( vol 10, e12450, 2024)(2024) Velioğlu, Halil Aziz[Abstract Not Available]Öğe Bridging the gap: a narrative review of osteoporosis disability, adipokines, and the role of AI in postmenopausal women(2024) Tariq, Saba; Jabbar, Sohail; Ahmad, Awais; Tariq, SundusOsteoporosis is a global health concern characterized by reduced bone density and compromised bone quality, resulting in an increased risk of fractures, particularly in postmenopausal women. The assessment of bone mineral density (BMD) plays a pivotal role in diagnosing osteoporosis, as it accounts for approximately 70% of overall bone strength. The World Health Organization (WHO) has endorsed BMD measurement as a reliable method for diagnosing this condition. In Pakistan, the incidence of bone fractures is on the rise, largely attributable to an aging population and a range of contributing factors. Understanding the global and local prevalence of osteoporosis, its impact on morbidity and mortality, and the contributing factors is vital for developing effective preventive and therapeutic strategies. The role of adipokines, including chemerin, vaspin, and omentin-1, in bone metabolism is an emerging area of investigation. These adipokines play diverse roles in physiology, ranging from inflammation and metabolic regulation to cardiovascular health. Understanding their potential impact on bone health is a topic of ongoing research. The intricate relationship between bone density, bone quality, and overall bone strength is central to understanding the diagnosis and management of osteoporosis. Current innovation in machine learning and predictive model can bring revolution in the field of bone health and osteoporosis. Early identification of people with osteoporosis or risk of fracture through machine learning can prevent disability and improve the quality of life.Öğe The role of digital health solutions in modern medicine(2024) Tariq, Saba; Tariq, Sundus[Abstract Not Available]Öğe Editorial: Immunologic tumor microenvironment modulators for turning “cold” tumors to “hot” tumors(2024) Ganjalıkhani Hakemi, Mazdak; Yanıkkaya Demirel, Gülderen; He, Xin; Zeng, Chengwu[Abstract Not Available]Öğe Editorial: The cognitive ageing collection(2024) Nicholls, Louise A. Brown; Amanzio, Martina; Güntekin, Bahar; Keage, HannahAlongside rapid population ageing, we are experiencing increasing numbers of people with cognitive impairment and dementia. There is great scientific effort being committed to understanding cognitive and brain functioning, with the aim of helping to promote healthy ageing and independence, and improve quality of life. This Cognitive Ageing Collection brings together cutting-edge research using a variety of methods and from diverse disciplinary perspectives, with example topics including cognitive strategies, genetic risk factors, and emotion regulation. Articles in the Collection highlight advances in our understanding of cognitive and brain health, and outline important directions for future research.Öğe Editorial: Modelling neurodevelopmental and neurodegenerative diseases for prognosis, diagnosis, and therapies(2024) Vilain, Sven[Abstract Not Available]Öğe Editorial: Osteoporosis and adipokines: the potential for future treatment(2024) Tariq, Saba; Tariq, Sundus; Baig, Mukhtiar; Valjevac, AminaOsteoporosis is a major health concern, particularly in older people. It is characterized by decreased bone density and a higher fracture risk. Globally, it affects 35.3% of women and 12.5% of men (1). Recent studies have concentrated on the role of adipokines in bone metabolism control and osteoporosis progression. Adipokines are signaling substances produced by adipose tissue. Leptin, resistin, chemerin, visfatin, and other proteins have been shown to alter bone metabolism, making them possible targets for future osteoporosis treatments (2–4).Öğe Data-driven medicine: The promise and potential of clinical decision support systems(University of Faisalabad, 2024) Tariq, Saba; Tariq, SundusPatient safety is one of the most important factors involved in any health care policy. The idea of evidence-based medicine has emerged as the dominant paradigm in clinical practice, influencing our current understanding of medicine. Clinical decisions are based on accumulated scientific information in order to provide the best possible care, enhance patient outcomes, and save expenses.Öğe Bioactive peptides: An alternative therapeutic approach for cancer management(Frontiers Media SA, 2024) Ghadiri, Nooshin; Javidan, Moslem; Sheikhi, Shima; Taştan, Özge; Parodi, Alessandro; Liao, Ziwei; Tayybi Azar, Mehdi; Ganjalıkhani-Hakemi, MazdakCancer is still considered a lethal disease worldwide and the patients’ quality of life is affected by major side effects of the treatments including post-surgery complications, chemo-, and radiation therapy. Recently, new therapeutic approaches were considered globally for increasing conventional cancer therapy efficacy and decreasing the adverse effects. Bioactive peptides obtained from plant and animal sources have drawn increased attention because of their potential as complementary therapy. This review presents a contemporary examination of bioactive peptides derived from natural origins with demonstrated anticancer, ant invasion, and immunomodulation properties. For example, peptides derived from common beans, chickpeas, wheat germ, and mung beans exhibited antiproliferative and toxic effects on cancer cells, favoring cell cycle arrest and apoptosis. On the other hand, peptides from marine sources showed the potential for inhibiting tumor growth and metastasis. In this review we will discuss these data highlighting the potential befits of these approaches and the need of further investigations to fully characterize their potential in clinics.Öğe Integrated multi-omics analyses of microbial communities: A review of the current state and future directions(Royal Society of Chemistry, 2023) Arıkan, Muzaffer; Muth, ThiloIntegrated multi-omics analyses of microbiomes have become increasingly common in recent years as the emerging omics technologies provide an unprecedented opportunity to better understand the structural and functional properties of microbial communities. Consequently, there is a growing need for and interest in the concepts, approaches, considerations, and available tools for investigating diverse environmental and host-associated microbial communities in an integrative manner. In this review, we first provide a general overview of each omics analysis type, including a brief history, typical workflow, primary applications, strengths, and limitations. Then, we inform on both experimental design and bioinformatics analysis considerations in integrated multi-omics analyses, elaborate on the current approaches and commonly used tools, and highlight the current challenges. Finally, we discuss the expected key advances, emerging trends, potential implications on various fields from human health to biotechnology, and future directions.Öğe Centralized healthcare database for ensuring better healthcare: Are we lagging behind?(Professional Medical Publications, 2024) Tariq, Sundus; Tariq, Saba; Shoukat, Ahmad AdnanDatabase is an organized set of large information gathered and stored electronically to be retrieved whenever required. The systematically stored information can be accessed, analyzed, updated or moved to other databases as per the requirement. A centralized healthcare database (CHD) is a memory house of health data from a wider population, where information such as health records, financial data, billing and claims information and inventory use is not only stored systematically but can also be retrieved, analyzed, and integrated. The data can be assessed by the health care providers, researchers, policy makers, institutions and by the patients themselves.
