An unknown side effect of isotretinoin: Pericardial effusion with atrial tachycardia

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dc.authorid0000-0002-4607-5724
dc.authorid0000-0003-1919-3183
dc.contributor.authorGüler, Ekrem
dc.contributor.authorGüler, Gamze Babür
dc.contributor.authorYavuz, Cahit
dc.contributor.authorKızılırmak, Filiz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:05Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:05Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractacne vulgaris and other dermatologic disorders. Systemic isotretinoin therapy may cause some cardiac side effects, like atrial tachycardia (1), congenital heart disease, and cardiac remodeling (2), reported as case reports. A 26-year-old female presented to the emergency unit of with syncope after a long palpitation episode. Her physical examination was normal except for tachycardia. A 12-lead electrocardiogram revealed atrial tachycardia, and the heart rate was 149 beats/min. After a 25-mg intravenous injection of diltiazem hydrochloride bolus, the atrial tachycardia terminated and normal sinus rhythm was sustained. Her laboratory tests and chest X-ray were normal. Echocardiography revealed normal left ventricular function and pericardial effusion of 0.8 cm at posterior side, 0.9 cm at the right atrial side and 1.3 cm at the right ventricle side. Several atrial tachycardia episodes were detected on rhythm Holter. During the longest episode of atrial tachycardia, the heart rate was 149 beats/min. The patient had been on oral isotretinoin therapy of 0.5 mg/kg/day for the previous 4 months because of nodular acne and was not using any other medication. After consulting with a dermatology physician, isotretinoin was stopped. Holter analysis revealed whole-day sinus rhythm 2 months after the drug therapy was interrupted. Echocardiography revealed gradual regression of pericardial effusion at the follow-up.
dc.identifier.citationGüler, E., Güler, G.,B., Yavuz, C. ve Kızılırmak, F. (2015) An unknown side effect of isotretinoin: Pericardial effusion with atrial tachycardia. Anatolian Journal of Cardiology, 15(2), 168-169. https://dx.doi.org/10.5152/akd.2015.5790
dc.identifier.doi10.5152/akd.2015.5790
dc.identifier.endpage169
dc.identifier.issn1302-8723
dc.identifier.issue2
dc.identifier.scopusqualityN/A
dc.identifier.startpage168
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1056
dc.identifier.urihttps://dx.doi.org/10.5152/akd.2015.5790
dc.identifier.volume15
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Society of Cardiology
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIsotretinoin
dc.subjectPericardial
dc.subjectTachycardia
dc.titleAn unknown side effect of isotretinoin: Pericardial effusion with atrial tachycardia
dc.typeLetter

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