Hunting glioblastoma recurrence: glioma stem cells as retrospective targets

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dc.contributor.authorMengüç Emir, Sümeyra
dc.contributor.authorKaraoğlan, Birnur Sinem
dc.contributor.authorKaşmer, Ramazan
dc.contributor.authorŞirin, Hilal Buse
dc.contributor.authorSarıyıldız, Batuhan
dc.contributor.authorKarakaş, Nihal
dc.date.accessioned2026-04-09T11:39:27Z
dc.date.available2026-04-09T11:39:27Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractGlioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain malignancies in adults. Standard approaches, including surgical resection followed by adjuvant radio- and chemotherapy with temozolomide (TMZ), provide only transient control, as GBM frequently recurs due to its infiltrative nature and the presence of therapy-resistant subpopulations such as glioma stem cells (GSCs). GSCs, with their quiescent state and robust resistance mechanisms, evade conventional therapies, contributing significantly to relapse. Consequently, current treatment methods for GBM face significant limitations in effectively targeting GSCs. In this review, we emphasize the relationship between GBM recurrence and GSCs, discuss the current limitations, and provide future perspectives to overwhelm the challenges associated with targeting GSCs. Eliminating GSCs may suppress recurrence, achieve durable responses, and improve therapeutic outcomes for patients with GBM.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) ; Istanbul Medipol University Scientific Research Project Commission
dc.identifier.citationMengüç Emir, S., Karaoğlan, B. S., Kaşmer, R., Şirin, H. B., Sarıyıldız, B. ve Karakaş, N. (2025). Hunting glioblastoma recurrence: glioma stem cells as retrospective targets. American Journal of Physiology - Cell Physiology, 328(3), C1045-C1061. http://dx.doi.org/10.1152/ajpcell.00344.2024
dc.identifier.doi10.1152/ajpcell.00344.2024
dc.identifier.endpageC1061
dc.identifier.issn0363-6143
dc.identifier.issn1522-1563
dc.identifier.issue3
dc.identifier.pmid39818986
dc.identifier.scopus2-s2.0-86000330650
dc.identifier.scopusqualityQ1
dc.identifier.startpageC1045
dc.identifier.urihttp://dx.doi.org/10.1152/ajpcell.00344.2024
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13407
dc.identifier.volume328
dc.identifier.wosWOS:001441569200003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMengüç Emir, Sümeyra
dc.institutionauthorKaraoğlan, Birnur Sinem
dc.institutionauthorŞirin, Hilal Buse
dc.institutionauthorSarıyıldız, Batuhan
dc.institutionauthorKarakaş, Nihal
dc.institutionauthorid0009-0007-5486-8402
dc.institutionauthorid0009-0002-5945-2848
dc.institutionauthorid0000-0002-9096-1512
dc.language.isoen
dc.relation.ispartofAmerican Journal of Physiology - Cell Physiology
dc.relation.publicationcategoryDiğer
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/1919B012000558
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/1919B012220136
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCancer Stem Cells
dc.subjectDrug Resistance
dc.subjectGlioblastoma
dc.subjectGlioma Stem Cells
dc.subjectRecurrence
dc.titleHunting glioblastoma recurrence: glioma stem cells as retrospective targets
dc.typeOther

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