Antioksidan maddelerin mutajenite üzerine etkilerinin ames testi ile incelenmesi

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dc.authorid0000-0002-2018-9619
dc.contributor.authorBeceren, Ayfer
dc.contributor.authorSarıkaya, Betül
dc.contributor.authorTatlıpınar, Eşref
dc.contributor.authorOmurtag, Gülden Zehra
dc.contributor.authorŞardaş, Semra
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:41Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı
dc.descriptionWOS: 000417368400005
dc.description.abstractNowadays, several test systems have been developed in order to observe the mutagenic effects of chemical agents which play crucial roles in human health. The Ames Test is one of these test systems. With the Ames Test, some bacterial mutants have been discovered to investigate the mutagenic effects of the chemicals. Various strains of Salmonella typhimurium are one of the groups of the bacterial mutants in question. The aim of this study is to investigate possible antimutagenic effect of Pelargonium sidoides which have an antioxidant effect towards carcinogenic substance called 2-aminofluorene by Ames/Salmonella/Microsome test kit in the absence and presence of metabolic activation. TA 98 and TA 100 strains were used in these experiments. TA 98 is designed for frame-shift mutagens and TA 100 is designed for base-pair mutagens. The antimutagenic activity was screened in two groups with or without S9 metabolic activation. The results were evaluated the mean average values and compared with positive and negative controls. In conclusion, it was shown that Pelargonium sidoides have antimutagenic effect towards TA 98 and TA 100 without S9 metabolic activation (p >= 0.05) but have no antimutagenic effect towards TA 98 and TA 100 with S9 metabolic activation (p <= 0.05).
dc.identifier.citationBeceren, A., Sarıkaya, B., Tatlıpınar, E., Omurtag, G. Z. ve Şardaş, S. (2017). Antioksidan maddelerin mutajenite üzerine etkilerinin ames testi ile incelenmesi. Marmara Pharmaceutical Journal, 21(3), 455-460. https://dx.doi.org/10.12991/marupj.306790
dc.identifier.doi10.12991/marupj.306790
dc.identifier.endpage460
dc.identifier.issn1309-0801
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage455
dc.identifier.urihttps://dx.doi.org/10.12991/marupj.306790
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3402
dc.identifier.volume21
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherMarmara Üniversitesi
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmes Testi
dc.subjectAntioksidan
dc.subjectPelargonium Sidoides
dc.subjectS9 Fraksiyonu
dc.subjectMutajenisite
dc.subjectAmes Test
dc.subjectAntioxidant
dc.subjectPelargonium Sidoides
dc.subjectS9 Fraction
dc.subjectMutagenicity
dc.titleAntioksidan maddelerin mutajenite üzerine etkilerinin ames testi ile incelenmesi
dc.title.alternativeInvestigation of antioxidants's antimutagenic effects by the ames test
dc.typeArticle

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