The heart of the matter: Cardiac stem cells

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dc.contributor.authorÇağavi, Esra
dc.contributor.authorKoç, Arzuhan
dc.contributor.authorGöktaş Şahoğlu, Sevilay
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:49Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:49Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractCardiovascular diseases are the primary cause of death in the world. Pharmacological and surgical approaches are the main treatment options for heart disease; however, heart transplantation may be the only option for advanced heart failure patients despite its limited nature. Recent advances enabled stem cell-based therapies to become a promising treatment approach for injured or weakened cardiac tissue. With the identification of resident and heart-specific stem cells in early 2000, new avenues of research have been opened to understand heart development, disease, and regeneration. In this review article, different cardiac stem cell subpopulations are classified and defined based on the expression of various characteristic surface or intracellular proteins, including, but not limited to, C-kit, Sca-1, Isl-1, Nkx2.5, HCN4, SIRPA, Flt-1, and KDR. Understanding cardiac stem cell biology, self-renewal, and differentiation mechanisms holds great promise for directing these processes and utilizing these cells to repair or even build new hearts.
dc.identifier.citationÇağavi, E., Koç, A. ve Göktaş Şahoğlu, S. (2016). The heart of the matter: Cardiac stem cells. Turkish Journal of Biology, 40(5), 968-980. https://dx.doi.org/10.3906/biy-1602-63
dc.identifier.endpage980
dc.identifier.issn1300-0152
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage968
dc.identifier.urihttps://hdl.handle.net/20.500.12511/493
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1602-63
dc.identifier.volume40
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStem Cell
dc.subjectCardiac Stem Cells
dc.subjectHeart Disease
dc.subjectCardiac Development
dc.titleThe heart of the matter: Cardiac stem cells
dc.typeOther

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