Myelin disorders and stem cells: As therapies and models

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dc.authorid0000-0003-1106-3288
dc.contributor.authorAydınlı, Fatmagül İlayda
dc.contributor.authorÇelik, Eşref
dc.contributor.authorKurt Vatandaşlar, Burcu
dc.contributor.authorKerman, Bilal Ersen
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:47Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:47Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractMyelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. The basis and/or the mechanism of demyelination is not known for many of the disorders either. In recent years, stem cells of variable origin have been used in clinical trials as transplant agents to restore the defective biochemical process or the damaged tissue. We summarize the outcomes of these trials for demyelination disorders. The capability of reprograming mature cells into stem cells equips researchers with a new tool to replicate disease phenotypes in cell culture dishes for basic research and therapeutic screens. The applications of in vitro myelination disorder models are also discussed. The combined outcome of the discussed studies offers a promising future as stem cell transplantation generally results in decreased symptoms and improved quality of life. However, the mechanism of action of the interventions is not known and in cases of negative outcomes the reasons are usually obscure. Further basic science studies along with clinical interventions should close the knowledge gap and should help spread the positive results to a larger population.
dc.identifier.citationAydınlı, F. İ., Çelik, E., Kurt Vatandaşlar, B. ve Kerman, B. E. (2016). Myelin disorders and stem cells: As therapies and models. Turkish Journal of Biology, 40(5), 1068-1080. https://dx.doi.org/10.3906/biy-1512-83
dc.identifier.endpage1080
dc.identifier.issn1300-0152
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage1068
dc.identifier.urihttps://hdl.handle.net/20.500.12511/479
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1512-83
dc.identifier.volume40
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStem Cells
dc.subjectInduced Pluripotent Stem Cells
dc.subjectMyelin
dc.subjectPelizaeus–Merzbacher Disease
dc.subjectAdrenoleukodystrophy
dc.subjectMultiple Sclerosis
dc.subjectSubacute Sclerosing Panencephalitis
dc.titleMyelin disorders and stem cells: As therapies and models
dc.typeReview Article

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