Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs
| dc.authorid | 0000-0002-5976-676X | |
| dc.authorid | 0000-0003-1896-2729 | |
| dc.authorid | 0000-0002-0841-1299 | |
| dc.contributor.author | Şahin, Zafer | |
| dc.contributor.author | Biltekin, Sevde Nur | |
| dc.contributor.author | Yurttaş, Leyla | |
| dc.contributor.author | Demirayak, Şeref | |
| dc.date.accessioned | 2021-01-07T07:12:21Z | |
| dc.date.available | 2021-01-07T07:12:21Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | |
| dc.description.abstract | Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR (H-1, C-13) and HRMS spectrums. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microclilution method. Among the series, 3bc-3cf showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There is lesser activity for 2-pyridyl activity for 2-pyridyl containing group, which may be a result of intramolecular interactions. No activity was observed against gram-negative bacteria at 250 mu g/mL. 3ae and 3ce showed activity at 64 mu g/mL against S. aureus and 3ae showed activity at 16 pg/ml. against S. epidermidis gram-positive bacteria. Chloramphenicol showed activity against all microorganisms at 8-16 mu g/mL. Sixteen original dendrodoine analogs have been defined by close/higher activity compared to dendrodoine analogs and Trolox. | |
| dc.identifier.citation | Şahin, Z., Biltekin, S. N., Yurttaş, L. ve Demirayak, Ş. (2020). Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs. Turkish Journal of Chemistry, 44(6), 1733-1741. https://dx.doi.org/10.3906/kim-2008-8 | |
| dc.identifier.doi | 10.3906/kim-2008-8 | |
| dc.identifier.endpage | 1741 | |
| dc.identifier.issn | 1300-0527 | |
| dc.identifier.issue | 6 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 1733 | |
| dc.identifier.uri | https://dx.doi.org/10.3906/kim-2008-8 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/6192 | |
| dc.identifier.volume | 44 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Scientific and Technical Research Council of Turkey | |
| dc.relation.ispartof | Turkish Journal of Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Antioxidant | |
| dc.subject | Antimicrobial | |
| dc.subject | Thiazole | |
| dc.subject | Dendrodoine | |
| dc.title | Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs | |
| dc.type | Article |
