In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract

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dc.authorid0000-0002-9096-1512
dc.authorid0000-0002-3412-0807
dc.authorid0000-0002-1896-2932
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorKarakaş, Nihal
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorYılmaz, Rabia
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2020-02-26T13:51:18Z
dc.date.available2020-02-26T13:51:18Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description.abstractMarrubium vulgare L. (Lamiaceae) is a herbal drug used for centuries for many diseases. In this present study the plant material was acquired from commercial sources in pharma grade (PhEur 8.0) quality. The methanol extract of the aerial parts was evaluated for its in vitro cytotoxic activity by measuring the percentage of viable cells (U87 LN229 and T98G glioblastoma multiforme cell lines) using a luminescence system, and the antioxidant activities by ABTS and DPPH radical scavenging spectrophotometrically. As a result, the methanol extract of M. vulgare showed 48.97 ± 0.82 mg of GA/g corresponding to the total phenolic amounts, and moderate antioxidant activity (1.33 and 2.08) by ABTS• and DPPH• assays. To the best of knowledge, after evaluation of the cytotoxicity on M. vulgare treated U87 (IC50:270.3 ?M), LN229 (IC50:343.9 ?M) and T98G (336.6 ?M) glioblastoma multiforme (GBM) cell lines, significant cytotoxic activities with 69.9% (p= 0.0081) and 71% cell viability (p= 0.0028) was observed in M. vulgare treated U87 and LN229 GBM cell lines, respectively. Overall, further in vitro and in vivo bioactivity studies based on phytochemistry on various M. vulgare preparations are worthwhile in order to discover bioactive secondary metabolites.
dc.identifier.citationOkur, M. E., Karakaş, N., Karadağ, A. E., Yılmaz, R. ve Demirci, F. (2019). In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract. Journal of Research in Pharmacy, 23(4), 711-718. http://doi.org/10.12991/jrp.2019.180
dc.identifier.doi10.12991/jrp.2019.180
dc.identifier.endpage718
dc.identifier.issn2630-6344
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage711
dc.identifier.urihttp://doi.org/10.12991/jrp.2019.180
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4959
dc.identifier.volume23
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytotoxicity-1
dc.subjectGlioblastoma Multiforme Cell Lines-2
dc.subjectU87-3
dc.subjectLN229-4
dc.subjectT98G-5
dc.subjectMarrubium Vulgare-6
dc.titleIn vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract
dc.typeArticle

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