Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey

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dc.authorid0000-0003-2493-9664
dc.authorid0000-0003-1896-2729
dc.authorid0000-0001-8241-647X
dc.authorid0000-0002-5532-2395
dc.authorid0000-0002-2018-9619
dc.contributor.authorOmurtag Özgen, Pınar Sinem
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorİduğ, Tuğba
dc.contributor.authorMacit, Çağlar
dc.contributor.authorAyran, İrem
dc.contributor.authorÇelik, Sadiye Ayşe
dc.contributor.authorKültür, Şükran
dc.contributor.authorKan, Yüksel
dc.contributor.authorOmurtag, Gülden Zehra
dc.date.accessioned2022-07-25T13:01:40Z
dc.date.available2022-07-25T13:01:40Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı
dc.description.abstractThe essential oil obtained from Lavandula angustifolia Mill. (Lavander) has many pharmacological effects, including antioxidant, antifungal, antibacterial and carminative effects. Lavandula angustifolia essential oil (LEO) contains monoterpene compounds, mainly linalool and linalyl acetate and various phenolic acids such as caffeic acid, vanillic acid, ferulic acid and chlorogenic acid. The hydrodistillation of the aerial parts of L. angustifolia produced a pale yellow oil. Gas chromatography-Gas chromatography/Massspectrometry (GC-GC/MS) results showed that LEO contains monoterpene alcohols that primarily include linalool (35.91%), 4-Terpineol (6.10%), ?-Terpineol (4.49%) and lavandulol (2.49%). As a result of the cytotoxicity analysis of LEO, the IC50 value was found to be 0.372 mg/mL. LEO was found to be non-mutagenic against the bacterial test strain Salmonella typhimurium TA 98 with S9 fraction while the highest concentration (9.58 mg/mL) was found to be either mutagenic or cytotoxic against TA 98 without S9 fraction. The essential oil’s antioxidant capacity was found 6.522±0.069 mg/mL while the total phenolic content was 1.22±0.04 mg GAE/g extract (Gallic acid equivalent/g extract). Anti-inflammatory activity of LEO was 1.238± 0.026 mg/mL while that of indomethacine was 0.022±0.003 mg/mL. In conclusion, when the results are evaluated in terms of in vitro biological activities, LEO can be considered as a potential herbal product with active compounds that should be examined in future studies.
dc.description.sponsorshipIstanbul Medipol Universityen_US
dc.identifier.citationOmurtag Özgen, P. S., Biltekin, S. N., İduğ, T., Macit, Ç., Ayran, İ., Çelik, S. A. ... Omurtag, G. Z. (2022). Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey. Journal of Research in Pharmacy, 26(4), 781-789. https://doi.org/10.29228/jrp.175
dc.identifier.doi10.29228/jrp.175
dc.identifier.endpage789
dc.identifier.issn2630-6344
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85133896597
dc.identifier.scopusqualityQ3
dc.identifier.startpage781
dc.identifier.trdizinid535906
dc.identifier.urihttps://doi.org/10.29228/jrp.175
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9606
dc.identifier.volume26
dc.identifier.wos000836312200007en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorOmurtag Özgen, Pınar Sinem
dc.institutionauthorBiltekin, Sevde Nur
dc.institutionauthorİduğ, Tuğba
dc.institutionauthorMacit, Çağlar
dc.institutionauthorOmurtag, Gülden Zehra
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant Activity
dc.subjectCytotoxicity
dc.subjectEssential Oil
dc.subjectLavandula Angustifolia
dc.subjectMutagenity
dc.titleChemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey
dc.typeArticle

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