A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma

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dc.authorid0000-0002-3385-8359
dc.authorid0000-0002-7424-8688
dc.authorid0000-0002-5715-8138
dc.authorid0000-0001-8902-5498
dc.authorid0000-0002-9815-1848
dc.authorid0000-0003-1237-8281
dc.authorid0000-0001-8930-741X
dc.authorid0000-0001-8945-2385
dc.authorid0000-0001-9636-4113
dc.contributor.authorGemici, Aliihsan
dc.contributor.authorBilgen, Hülya
dc.contributor.authorErdoğan, Cem
dc.contributor.authorKansu, Abdullah
dc.contributor.authorOlmuşçelik, Oktay
dc.contributor.authorBeköz, Hüseyin Saffet
dc.contributor.authorDinleyici, Rümeysa
dc.contributor.authorMert, Ali
dc.contributor.authorSevindik, Ömür Gökmen
dc.date.accessioned2021-01-14T07:16:53Z
dc.date.available2021-01-14T07:16:53Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Health authority in Turkey has published a guideline to integrate this promising option in the treatment process of patients who are prone to high risk of developing severe COVID-19.Materials and Methods: Forty consecutive patients who had received CP at our center were included in the study. Demographics, COVID-19 specific parameters, biomarkers to detect the severity of COVID-19 infection and outcome variables were collected retrospectively. The correlation between outcome variables and the independent predictors of the outcome were reported.Results: Median age of the patients was 57.5 and 72.5% were male. At least one COVID-19 PCR test was confirmed to be positive in 75% of patients. Remaining 25% had a Chest-CT which was reported to be compatible with an ongoing COVID-19. All patients (100%) were classified as having severe COVID-19 infection. Over a half of the patients harbored an oxygen saturation of less than 90 despite of a continuous 5 L/min support of O-2. 82.5% of the patients had a need for mechanical ventilation and 45.5% had a need for invasive mechanical ventilation. Nine out of 10 patients who have received CP outside ICU have totally recovered from COVID-19 at a median of 9 days, and a half of the patients who needed invasive mechanical ventilation were successfully free of mechanical ventilation support and managed to recover from COVID-19.Conclusion: According to the results of this study, CP is an efficient conjunct to conventional therapy against COVID-19 with a favorable safety profile.
dc.identifier.citationGemici, A., Bilgen, H., Erdoğan, C., Kansu, A., Olmuşçelik, O., Beköz, H. S. ... Sevindik, Ö. G. (2020). A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma. Turkish Journal of Medical Sciences, 50(8), 1781-1785. https://dx.doi.org/10.3906/sag-2009-77
dc.identifier.doi10.3906/sag-2009-77
dc.identifier.endpage1785
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue8
dc.identifier.scopusqualityQ3
dc.identifier.startpage1781
dc.identifier.urihttps://dx.doi.org/10.3906/sag-2009-77
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6239
dc.identifier.volume50
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTübitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectConvalescent Plasma
dc.subjectCOVID-19
dc.subjectViral Infections
dc.titleA single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma
dc.typeArticle

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