In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of clematis viticella L.

Basit Öğe Kaydı
dc.authorid0000-0003-38824526
dc.contributor.authorAcar Şah, Esra
dc.contributor.authorCelep, Engin
dc.contributor.authorYeşilada, Erdem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:50Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.descriptionWOS: 000459615300021
dc.description.abstractSince biotransformation processes generally affect the biological activities of phytochemical compounds, bioavailability is one of the primary steps in determining the potency of the activity. Previous studies have shown that in vitro antioxidant capacity of phytochemicals cannot completely reflect real health benefits. Clematis species (Ranunculaceae) are used to eliminate the symptoms of many diseases including particularly in the treatment of rheumatic diseases in Turkey, however the number of studies conducted is limited. In the light of this information, the total phytochemical profile of the extract of aerial parts of C. viticella prepared with 80% methanol and the gastrointestinal digestion products and the antioxidant activity profile were evaluated by subjecting them to the in vitro simulation model of the human digestive tract in the study. It was observed that both total phytochemical content and antioxidant activity decreased after simulated human digestion. Moreover, this study was shown potential bioaccessibility and bioavailability of total phenol, phenolic acid, flavonoid, and saponin content found in the aerial parts of Clematis viticella were reduced. Consequently, these indicate that it can result from the complicated interaction of compounds in the plant matrix in an in vitro simulated human digestion.
dc.identifier.citationAcar Şah, E., Celep, E. ve Yeşilada, E. (2019). In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of clematis viticella L. Journal of Research in Pharmacy, 23(2), 326-335. https://dx.doi.org/10.12991/jrp.2019.140
dc.identifier.doi10.12991/jrp.2019.140
dc.identifier.endpage335
dc.identifier.issn2630-6344
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage326
dc.identifier.urihttps://dx.doi.org/10.12991/jrp.2019.140
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1784
dc.identifier.volume23
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectClematis Viticella L.
dc.subjectRanunculaceae
dc.subjectPhenolic Profile
dc.subjectAntioxidant Activity
dc.subjectIn Vitro Digestion Simulation Model
dc.subjectBioavailability
dc.subjectBioaccessibility
dc.titleIn vitro bioavailability studies on phytochemical profile and antioxidant activity potential of clematis viticella L.
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Acar Şah, Esra.pdf
Boyut:
864.14 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Eczacılık Fakültesi Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu