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Toplam kayıt 12, listelenen: 1-10
Nanokorlar: Tanı ve tedaviye yönelik antikor fragmanları
(2018)
Nanokorlar, bilinen en küçük ve fonksiyonel antikor fragmanlarıdır. Yapısında sadece iki ağır zincir bulunduran antikorların (heavy chain only antibodies; HcAb) antijen bağlama bölgesi, “nanokor” (nanobody) olarak ...
Protein and gene delivery systems for neurodegenerative disorders: Where do we stand today?
(MDPI, 2022)
It has been estimated that every year, millions of people are affected by neurodegenerative disorders, which complicate their lives and their caregivers’ lives. To date, there has not been an approved pharmacological ...
Chemogenetic tools for causal cellular and neuronal biology
(American Physiological Society, 2018)
Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological ...
Mesenchymal stem cell applications in polycystic ovary syndrome treatment
(Ondokuz Mayıs Üniversitesi, 2021)
Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under ...
Early diagnosis of Alzheimer's disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts
(Elsevier Ireland Ltd., 2020)
Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly with a progressive decline in cognitive function significantly affecting quality of life. Both the prevalence and emotional and financial ...
Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke
(NLM (Medline), 2020)
Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood ...
Myelin disorders and stem cells: As therapies and models
(Tubitak Scientific & Technical Research Council, 2016)
Myelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. ...
Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?
(Wiley, 2017)
Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms ...
Therapeutic role of rifampicin in Alzheimer's disease
(Wiley, 2018)
Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its ...
Helper innate lymphoid cells as cell therapy for cancer
(Wiley, 2023)
Although the first cancer immunotherapy was given in the clinic more than a century ago, this line of treatment has remained more of a distant goal than a practical therapy due to limited understanding of the tumour ...