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Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?

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info:eu-repo/semantics/openAccess

Date

2017

Author

Yuluğ, Burak
Hanoğlu, Lütfü
Kılıç, Ertuğrul

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Yuluğ, B., Hanoğlu, L. ve Kılıç, E. (2017). Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease? Psychiatry and Clinical Neurosciences, 71(10), 673-677. https://dx.doi.org/10.1111/pcn.12539

Abstract

Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (A) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in A clearance metabolism. To that end, we discuss possible mechanisms underlying the bidirectional interaction between the sleep deprivation and A clearance pathways.

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Psychiatry and Clinical Neurosciences

Volume

71

Issue

10

URI

https://dx.doi.org/10.1111/pcn.12539
https://hdl.handle.net/20.500.12511/3712

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