ORCID "0000-0001-6494-8923" Makale Koleksiyonu için listeleme
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Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25
Kuang, Yaoyun; Zheng, Xuan; Zhang, Lin; Ai, Xiaoyu; Venkataramani, Vivek; Kılıç, Ertuğrul; Hermann, Dirk M.; Majid, Arshad; Baehr, Mathias; Doeppner, Thorsten R. (Taylor & Francis Ltd, 2020)Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has not yet been identified. To investigate ... -
Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Altunay, Serdar; Tuzcu, Mehmet; Erten, Füsun; Orhan, Cemal; Günal, Mehmet Yalçın; Yuluğ, Burak; Juturu, Vijaya; Şahin, Kazım (Springer, 2019)Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative ... -
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?
Günal, Mehmet Yalçın; Şahinler Ayla, Sibel; Çaglayan, Berrak; Beker, Mustafa Çağlar; Bedri, Nejda; Aslan, İpek Bilge; Özdemir, Ekrem Musa; Kılıç, Ertuğrul; Yeşilada, Elif (Comenius University, 2021)OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, ... -
Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
Doeppner, Thorsten Roland; Kaltwasser, Britta; Schlechter, Jana; Jaschke, J.; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias; Weise, Jens (Nature Publishing Group, 2015)Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ... -
Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
Yuluğ, Burak; Kılıç, Ertuğrul; Altunay, Serdar; Ersavaş, Cenk; Orhan, Cemal; Dalay, Arman; Tuzcu, Mehmet; Şahin, Nurhan; Juturu, Vijaya; Şahin, Kazım (Bentham Science Publishers Ltd, 2018)Introduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. ... -
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
Kılıç, Ülkan; Elibol, Birsen; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Beker, Merve; Altuğ Tasa, Burcugül; Uysal, Ömer; Yılmaz, Bayram; Kılıç, Ertuğrul (Springer Nature, 2022)Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Keskin, İlknur; Günal, Mehmet Yalçın; Aytürk, Nilüfer; Kılıç, Ülkan; Ozansoy, Mehmet; Kılıç, Ertuğrul (Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ... -
The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury
Diker, Nurettin; Çağlayan, Berrak; Helvacıoğlu, Fatma; Kılıç, Ertuğrul (Wiley, 2020)Axonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti-apoptotic, anti-inflammatory, and anti-oxidant effects on nerve ... -
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
Beker, Mustafa; Çağlayan, Ahmet Burak; Keleştemur, Taha; Çaǧlayan, Berrak; Yalçın, Esra; Yuluǧ, Burak; Kılıç, Ülkan; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Impact Journals, 2015)In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ... -
Enhancement of cisplatin sensitivity in human cervical cancer: Epigallocatechin-3-gallate
Kılıç, Ülkan; Şahin, Kazım; Tuzcu, Mehmet; Başak, Nazlı; Orhan, Cemal; Elibol Can, Birsen; Kılıç, Ertuğrul; Şahin, Fikrettin; Küçük, Ömer (Frontiers Media, 2015)Cisplatin is one of the effective chemotherapeutics in the treatment of several types of cancers. However, in addition to the efforts against to its toxicity, the amelioration of cisplatin sensitivity is an important point ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ... -
Evidence that osteogenic and neurogenic differentiation capability of epidural adipose tissue-derived stem cells was more pronounced than in subcutaneous cells
Solmaz, Bilgehan; Şahin, Ali; Keleştemur, Taha; Kılıç, Ertuğrul; Kaptanoğlu, Erkan (Tübitak Scientific & Technical Research Council Turkey, 2020)Background/aim: The management of dura-related complications, such as the repairment of dural tears and reconstruction of large dural defects, remain the most challenging subjects of neurosurgery. Numerous surgical techniques ... -
Extracellular vesicles derived from neural progenitor cells--a preclinical evaluation for stroke treatment in mice
Zheng, Xuan; Zhang, Lin; Kuang, Yaoyun; Venkataramani, Vivek; Jin, Fengyan; Hein, Katharina; Zafeiriou, Maria Patapia; Lenz, Christof; Moebius, Wiebke; Kılıç, Ertuğrul; Hermann, Dirk Matthias; Weber, Martin S.; Urlaub, Henning; Zimmermann, Wolfram Hubertus; BäHR, Mathias; Doeppner, Thorsten Roland (Springer, 2021)Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, ... -
Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-beta/Smad2/3 pathway
Zhang, Lin; Wei, Wei; Ai, Xiaoyu; Kılıç, Ertuğrul; Hermann, Dirk M.; Venkataramani, Vivek; Baehr, Mathias; Doeppner, Thorsten R. (Springer Nature, 2021)Systemic transplantation of oxygen-glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. ... -
Identification of PDE10A related proteins via proteomic analysis
Beker, Mustafa Çağlar; Yelkenci, Hayriye Ecem; Çağlayan, Berrak; Kılıç, Ertuğrul (İnönü University Faculty of Medicine, 2022)Aim: Phosphodiesterase 10A (PDE10A) regulates the expression of secondary messengers of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which control several intracellular signaling pathways. Recently, ... -
The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration
Doeppner, Thorsten Roland; Pehlke, Jens; Kaltwasser, Britta; Schlechter, Jana; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Nature Publishing Group, 2015)Cerebral ischemia stimulates N-methyl-D-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study ...