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Toplam kayıt 9, listelenen: 1-9
Enhancement of cisplatin sensitivity in human cervical cancer: Epigallocatechin-3-gallate
(Frontiers Media, 2015)
Cisplatin is one of the effective chemotherapeutics in the treatment of several types of cancers. However, in addition to the efforts against to its toxicity, the amelioration of cisplatin sensitivity is an important point ...
Protein kinaz C aktivatörü PMA’nın TRPV1 kanalları üzerindeki etkileri
(Hacettepe Üniversitesi, 2015)
TRP alt ailesinin bir üyesi olarak bilinen TRPV1 kanalları non-selektif katyon kanallarıdır. Bu kanalların en fazla bulunduğu dokular; arka kök gangliyon nöronları, vagal nöronlar ve trigeminal gangliyon nöronlarıdır. TRPV1 ...
Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
(Nature Publishing Group, 2015)
Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ...
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
(Impact Journals, 2015)
In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ...
The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis
(Impact Journals, 2015)
N-methyl-D-aspartate receptor (NMDAR) activation induces excitotoxicity, contributing to post-stroke brain injury. Hitherto, NMDAR deactivation failed in clinical trials due to insufficient pre-clinical study designs and ...
The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration
(Nature Publishing Group, 2015)
Cerebral ischemia stimulates N-methyl-D-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study ...
In vitro myelin formation using embryonic stem cells
(Company of Biologists, 2015)
Myelination in the central nervous system is the process by which oligodendrocytes form myelin sheaths around the axons of neurons. Myelination enables neurons to transmit information more quickly and more efficiently and ...
Color stability and surface roughness of a laboratory-processed composite resin as a function of mouthrinse
(Wiley, 2015)
Statement of the Problem: Mouthrinses can cause discoloration on indirect resin composites. Purpose of the Study: The purpose of the study was to investigate the effect of different mouthrinses on the color changes and ...
GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy
(Taylor and Francis, 2015)
Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic ...