GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy
Çıkrıkçıoğlu, Mehmet Ali
Yasin Çetin, Ayşe İrem
Erkal, Sena Nur
İsen, Hayati Can
MetadataShow full item record
CitationErkoç, R., Çıkrıkçıoğlu, M. A., Aintab, E., Erek-Toprak, A., Kılıç, Ü., Gök, Ö. ... Karatoprak, C. (2015). GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy. Renal Failure, 37(5), 866-870. https://dx.doi.org/10.3109/0886022X.2015.1034606
Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834+7G>A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus. Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834+7G>A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy. Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834+7G>A polymorphism (p = 0.837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p = 0.010). Conclusion: In our study, GAS6 intron 8 c.834+7G>A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.