ORCID "0000-0003-4292-5717" Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) için listeleme
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Abnormalities in auditory and visual cognitive processes are differentiated with theta responses in patients with Parkinson's disease with and without dementia
Güntekin, Bahar; Aktürk, Tuba; Yıldırım, Ebru; Helvacı Yılmaz, Nesrin; Hanoğlu, Lütfü; Yener, Görsev (Elsevier, 2020)The research on the abnormalities of event-related oscillations in Parkinson's disease (PD) was mostly studied with cognitively normal patients. The present study aims to show the adverse effects of cognitive decline in ... -
Accelerated forgetting and verbal memory consolidation process in idiopathic nondement Parkinson's disease
Hanoğlu, Lütfü; Ercan, Fatma Betül; Mantar, Nagihan; Yılmaz, Nesrin Helvacı; Sitrava, Sevilay; Özer, Feriha F.; Yuluğ, Burak (Elsevier, 2019)Objective: Episodic memory impairment and underlying pathophysiology in Parkinson's Disease (PD) is poorly investigated. Formerly, it was thought to be a secondary effect of impairment in fronto-striatal circuit. However, ... -
Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Age related differences in the recognition of facial expression: Evidence from EEG event-related brain oscillations
Aktürk, Tuba; İşoğlu-Alkaç, Ümmühan; Hanoǧlu, Lütfü; Güntekin, Bahar (Elsevier B.V., 2020)Facial Expression (FE) recognition is a major marker of emotional ability. Behavioral studies show that FE recognition ability decreases with aging. Studying how event-related brain oscillations change with normal aging ... -
Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?
Güntekin, Bahar; Aktürk, Tuba; Arakaki, Xianghong; Bonanni, Laura; Del Percio, Claudio; Edelmayer, Rebecca; Farina, Francesca; Ferri, Raffaele; Hanoğlu, Lütfü; Kumar, Sanjeev; Lizio, Roberta; Lopez, Susanna; Murphy, Brian; Noce, Giuseppe; Randall, Fiona; Sack, Alexander T.; Stocchi, Fabrizio; Yener, Görsev; Yıldırım, Ebru; Babiloni, Claudio (John Wiley and Sons Inc, 2022)Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology ... -
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
Axillary microbiota is associated with cognitive impairment in parkinson's disease patients
Arıkan, Muzaffer; Yıldız, Zeynep; Kahraman Demir, Tuğçe; Helvacı Yılmaz, Nesrin; Şen, Aysu; Hanoğlu, Lütfü; Yıldırım, Süleyman (American Society for Microbiology, 2022)Cognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD), with a substantially negative impact on patient management and outcome. The development and progression of CI exhibits high ... -
Beyond the therapeutic effect of RTMS in Alzheimer’s disease: A possible neuroprotective role of hippocampal BDNF?: A minireview
Yuluğ, Burak; Hanoğlu, Lütfü; Khanmammadov, Elmir; Arıcı Düz, Özge; Polat, Burcu; Hanoğlu, Taha; Günal, Mehmet Yalçın; Kılıç, Ertuğrul (Bentham Science Publishers B.V., 2018)Repetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant ... -
Chemogenetic inhibition of MCH neurons does not alter memory performance in mice
Mutlu Burnaz, Özlem; Yuluğ, Burak; Öncül, Merve; Çelik, Eşref; Sayar Atasoy, Nilüfer; Çankaya, Şeyda; Hanoğlu, Lütfü; Velioğlu, Halil Aziz (Elsevier Masson s.r.l., 2022)Memory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consolidation ... -
Classification of patients with alzheimer's disease and dementia with lewy bodies using resting EEG selected features at sensor and source levels: A proof-of-concept study
San Martin, Rodrigo; J Fraga, Francisco; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Nobili, Flavio; Arnaldi, Dario; D'Antonio, Fabrizia; Lena, Carlo De; Güntekin, Bahar; Hanoğlu, Lütfü; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Ferri, Raffaele; Onofrj, Marco; Lopez, Susanna; Bonanni, Laura; Babiloni, Claudio (Bentham Science, 2021)Background: Early differentiation between Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) is important for accurate prognosis, as DLB patients typically show faster disease progression. Cortical neural networks, ... -
Cognitive impairment in parkinson's disease is reflected with gradual decrease of eeg delta responses during auditory discrimination
Güntekin, Bahar; Hanoğlu, Lütfü; Güner, Dilan; Helvacı Yılmaz, Nesrin; Çadırcı, Fadime; Mantar, Nagihan; Aktürk, Tuba; Emek Savaş, Derya Durusu; Özer, Feriha; Yener, Görsev; Başar, Erol (Frontiers Media Sa, 2018)Parkinson's disease (PD) is a neurodegenerative disease that is characterized by loss of dopaminergic neurons in the substantia nigra. Mild Cognitive impairment (MCI) and dementia may come along with the disease. New ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
The correlation of non-motor symptoms and sleep on balance in Parkinson's disease patients with normal cognition and mild cognitive impairment
Sarıcaoğlu, Mevhibe; Helvacı Yılmaz, Nesrin; Özer, Fahriye Feriha; Hanoğlu, Lütfü (Springer London Ltd, 2021)Background Parkinson's disease (PD) is characterized by non-motor symptoms (NMS) as well as by motor symptoms. Together with the impairment of cognitive functions, NMS and sleep also affect motor symptoms negatively. The ... -
Delta oscillatory responses as a general electrophysiological biomarker for cognitive disorders
Güntekin, Bahar; Hanoğlu, Lütfü; Aktürk, Tuba; Güner, Dilan; Turp-Gölbaşı, Bilge; Yener, Görsev; Başar, Erol (Elsevier Science Bv, 2016)Background: In the last decade research on delta oscillatoryresponses invaded the literature. One of thefirst research on thisarea showed that delta responses increase upon cognitive load(Başar and Stampfer 1985). After ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
Ayyıldız, Sevilay; Velioğlu, Halil Aziz; Ayyıldız, Behçet; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yıldırım, Süleyman; Atasever, Alper; Yuluğ, Burak (Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients
Toprak, Güven; Hanoğlu, Lütfü; Çakır, Tansel; Güntekin, Bahar; Velioğlu, Halil Aziz; Yuluğ, Burak (Bentham Science Publishers, 2022)Background: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes ... -
Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?
Yuluğ, Burak; Hanoğlu, Lütfü; Kılıç, Ertuğrul (Wiley, 2017)Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms ... -
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ... -
Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study
Fide, Ezgi; Ekmek Savaş, Derya Durusu; Aktürk, Tuba; Güntekin, Bahar; Hanoğlu, Lütfü; Yener, Görsev G. (Elsevier Ireland Ltd, 2019)Objectives: The present study aims to evaluate the amplitude and latency of event-related potentials (ERPs) P100, N170, VPP and N230 in individuals with Alzheimer's disease (AD) compared to healthy elderly controls, using ...