Yazar "Hanoğlu, Lütfü" için Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) listeleme
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Abnormalities in auditory and visual cognitive processes are differentiated with theta responses in patients with Parkinson's disease with and without dementia
Güntekin, Bahar; Aktürk, Tuba; Yıldırım, Ebru; Helvacı Yılmaz, Nesrin; Hanoğlu, Lütfü; Yener, Görsev (Elsevier, 2020)The research on the abnormalities of event-related oscillations in Parkinson's disease (PD) was mostly studied with cognitively normal patients. The present study aims to show the adverse effects of cognitive decline in ... -
Accelerated forgetting and verbal memory consolidation process in idiopathic nondement Parkinson's disease
Hanoğlu, Lütfü; Ercan, Fatma Betül; Mantar, Nagihan; Yılmaz, Nesrin Helvacı; Sitrava, Sevilay; Özer, Feriha F.; Yuluğ, Burak (Elsevier, 2019)Objective: Episodic memory impairment and underlying pathophysiology in Parkinson's Disease (PD) is poorly investigated. Formerly, it was thought to be a secondary effect of impairment in fronto-striatal circuit. However, ... -
Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?
Güntekin, Bahar; Aktürk, Tuba; Arakaki, Xianghong; Bonanni, Laura; Del Percio, Claudio; Edelmayer, Rebecca; Farina, Francesca; Ferri, Raffaele; Hanoğlu, Lütfü; Kumar, Sanjeev; Lizio, Roberta; Lopez, Susanna; Murphy, Brian; Noce, Giuseppe; Randall, Fiona; Sack, Alexander T.; Stocchi, Fabrizio; Yener, Görsev; Yıldırım, Ebru; Babiloni, Claudio (John Wiley and Sons Inc, 2022)Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology ... -
Axillary microbiota is associated with cognitive impairment in parkinson's disease patients
Arıkan, Muzaffer; Yıldız, Zeynep; Kahraman Demir, Tuğçe; Helvacı Yılmaz, Nesrin; Şen, Aysu; Hanoğlu, Lütfü; Yıldırım, Süleyman (American Society for Microbiology, 2022)Cognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD), with a substantially negative impact on patient management and outcome. The development and progression of CI exhibits high ... -
Beyond the therapeutic effect of RTMS in Alzheimer’s disease: A possible neuroprotective role of hippocampal BDNF?: A minireview
Yuluğ, Burak; Hanoğlu, Lütfü; Khanmammadov, Elmir; Arıcı Düz, Özge; Polat, Burcu; Hanoğlu, Taha; Günal, Mehmet Yalçın; Kılıç, Ertuğrul (Bentham Science Publishers B.V., 2018)Repetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant ... -
Chemogenetic inhibition of MCH neurons does not alter memory performance in mice
Mutlu Burnaz, Özlem; Yuluğ, Burak; Öncül, Merve; Çelik, Eşref; Sayar Atasoy, Nilüfer; Çankaya, Şeyda; Hanoğlu, Lütfü; Velioğlu, Halil Aziz (Elsevier Masson s.r.l., 2022)Memory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consolidation ... -
Classification of patients with alzheimer's disease and dementia with lewy bodies using resting EEG selected features at sensor and source levels: A proof-of-concept study
San Martin, Rodrigo; J Fraga, Francisco; Del Percio, Claudio; Lizio, Roberta; Noce, Giuseppe; Nobili, Flavio; Arnaldi, Dario; D'Antonio, Fabrizia; Lena, Carlo De; Güntekin, Bahar; Hanoğlu, Lütfü; Taylor, John Paul; McKeith, Ian; Stocchi, Fabrizio; Ferri, Raffaele; Onofrj, Marco; Lopez, Susanna; Bonanni, Laura; Babiloni, Claudio (Bentham Science, 2021)Background: Early differentiation between Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) is important for accurate prognosis, as DLB patients typically show faster disease progression. Cortical neural networks, ... -
Cognitive impairment in parkinson's disease is reflected with gradual decrease of eeg delta responses during auditory discrimination
Güntekin, Bahar; Hanoğlu, Lütfü; Güner, Dilan; Helvacı Yılmaz, Nesrin; Çadırcı, Fadime; Mantar, Nagihan; Aktürk, Tuba; Emek Savaş, Derya Durusu; Özer, Feriha; Yener, Görsev; Başar, Erol (Frontiers Media Sa, 2018)Parkinson's disease (PD) is a neurodegenerative disease that is characterized by loss of dopaminergic neurons in the substantia nigra. Mild Cognitive impairment (MCI) and dementia may come along with the disease. New ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
The correlation of non-motor symptoms and sleep on balance in Parkinson's disease patients with normal cognition and mild cognitive impairment
Sarıcaoğlu, Mevhibe; Helvacı Yılmaz, Nesrin; Özer, Fahriye Feriha; Hanoğlu, Lütfü (Springer London Ltd, 2021)Background Parkinson's disease (PD) is characterized by non-motor symptoms (NMS) as well as by motor symptoms. Together with the impairment of cognitive functions, NMS and sleep also affect motor symptoms negatively. The ... -
Delta oscillatory responses as a general electrophysiological biomarker for cognitive disorders
Güntekin, Bahar; Hanoğlu, Lütfü; Aktürk, Tuba; Güner, Dilan; Turp-Gölbaşı, Bilge; Yener, Görsev; Başar, Erol (Elsevier Science Bv, 2016)Background: In the last decade research on delta oscillatoryresponses invaded the literature. One of thefirst research on thisarea showed that delta responses increase upon cognitive load(Başar and Stampfer 1985). After ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
Ayyıldız, Sevilay; Velioğlu, Halil Aziz; Ayyıldız, Behçet; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yıldırım, Süleyman; Atasever, Alper; Yuluğ, Burak (Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients
Toprak, Güven; Hanoğlu, Lütfü; Çakır, Tansel; Güntekin, Bahar; Velioğlu, Halil Aziz; Yuluğ, Burak (Bentham Science Publishers, 2022)Background: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes ... -
Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?
Yuluğ, Burak; Hanoğlu, Lütfü; Kılıç, Ertuğrul (Wiley, 2017)Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms ... -
EEG alpha activity increased in response to transcutaneous electrical nervous stimulation in young healthy subjects but not in the healthy elderly
Yıldırım, Ebru; Güntekin, Bahar; Hanoğlu, Lütfü; Algun, Zeliha Candan (PeerJ Inc, 2020)Transcutaneous Electrical Nerve Stimulation (TENS) is used not only in the treatment of pain but also in the examination of sensory functions. With aging, there is decreased sensitivity to somatosensory stimuli. It is ... -
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ... -
Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study
Fide, Ezgi; Ekmek Savaş, Derya Durusu; Aktürk, Tuba; Güntekin, Bahar; Hanoğlu, Lütfü; Yener, Görsev G. (Elsevier Ireland Ltd, 2019)Objectives: The present study aims to evaluate the amplitude and latency of event-related potentials (ERPs) P100, N170, VPP and N230 in individuals with Alzheimer's disease (AD) compared to healthy elderly controls, using ... -
FDG-PET scanning shows distributed changes in cortical activity associated with visual hallucinations in eye disease
Hanoğlu, Lütfü; Yıldız, Sultan; Çakır, Tansel; Hanoğlu, Taha; Yuluğ, Burak (Bentham Science Publ Ltd, 2019)Background and Objective: Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the ...