Başlık için Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) listeleme
Toplam kayıt 368, listelenen: 191-210
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The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis
(Impact Journals, 2015)N-methyl-D-aspartate receptor (NMDAR) activation induces excitotoxicity, contributing to post-stroke brain injury. Hitherto, NMDAR deactivation failed in clinical trials due to insufficient pre-clinical study designs and ... -
Inhibition of fatty acid synthesis aggravates brain injury, reduces blood-brain barrier integrity and impairs neurological recovery in a murine stroke model
(Frontiers Media SA, 2021)Inhibition of fatty acid synthesis (FAS) stimulates tumor cell death and reduces angiogenesis. When SH-SY5Y cells or primary neurons are exposed to hypoxia only, inhibition of FAS yields significantly enhanced cell injury. ... -
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
(NLM (Medline), 2022)Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ... -
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
(Taylor and Francis Ltd., 2022)Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ... -
Integrated multi-omics analyses of microbial communities: A review of the current state and future directions
(Royal Society of Chemistry, 2023)Integrated multi-omics analyses of microbiomes have become increasingly common in recent years as the emerging omics technologies provide an unprecedented opportunity to better understand the structural and functional ... -
Integrative analysis of axolotl gene expression data from regenerative and wound healing limb tissues
(Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ... -
Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation
(International Institute of Anticancer Research, 2021)Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ... -
Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
(Nature Publishing Group, 2019)The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ... -
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo
(Oxford University Press, 2017)Aims Fibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing stent tissue coverage as a ... -
Investigating the effects of glucose and lipid metabolism on neuronal structure using optical coherence tomography in treatment-resistant schizophrenia
(Kare Publishing, 2023)Objective:The effects of metabolic changes on neural structures in the later stages of schizophrenia remain unknown. Alterations in glucose and lipid metabolism could impact disease progression. This study aims to investigate ... -
Investigation of antioxidant and cytotoxic activities of Opuntia ficus-indica (L.) Mill. fruit extract
(Istanbul University, 2019)Opuntia ficus-indica fruits are claimed to possess several health-beneficial properties. This study was carried out to determine the phytochemicals as well as to compare antioxidant activity and cell viability of the ... -
The investigation of genetic etiology in familial cases with congenital hypothyroidism
(Karger, 2019)Background: Congenital hypothyroidism(CH) is the most common neonatal endocrinological disorder in the world. Although most of the CH is sporadic, some genetic defects are responsible from the etiology. The aim of this ... -
The investigation of inflammation in drug-naive first-episode mania by measuring ferritin, peripheral inflammatory markers, and their ratios
(Istanbul University, 2024)Objective: Bipolar disorder (BD) is a complex psychiatric disorder with a multifactorial etiology involving both genetic and environmental factors. Increased inflammatory parameters have been shown in previous studies in ... -
Investigation of possible effect of carnosic acid (CA) on combined exposure to bisphenol a (BPA) and diethyl hexyl phthalate (DEHP)
(Elsevier Ireland Ltd, 2018)DEHP and BPA, the main components of plastic products, are the important endocrine-disrupting chemicals which can mimic or disrupt the actions of estrogen by inhibiting normal functions of the body. Because of this widespread ... -
Investigation of the effect of adalimumab on experimental brain injury in mice
(2019)Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect". Methods: ... -
Is there a relationship between microvascular complications and the severity of type 2 diabetes mellitus?
(Erciyes University Faculty Of Medicine, 2020)Objective: The aim of this study was to determine the relationship between microvascular Type 2 diabetes mellitus (T2DM) complications and the severity and duration of diabetes in the light of sociodemographic and lifestyle ... -
Ischemic post-conditioning induces post-stroke neuroprotection via Hsp70-mediated proteasome inhibition and facilitates neural progenitor cell transplantation
(Humana Press Inc, 2017)In view of the failure of pharmacological therapies, alternative strategies promoting post-stroke brain repair are needed. Post-conditioning is a potentially promising therapeutic strategy, which induces acute neuroprotection ... -
Kurumda ve kendi evinde yaşayan bir grup yaşlı bireyin beslenme durumlarının değerlendirilmesi
(2020)Yaşlı nüfusun birçok ülkede olduğu gibi ülkemizde de hızla arttığı bilinmektedir. Yaşlılık döneminde, sağlığın iyileştirilmesi ve geliştirilmesinde, yaşam süresinin ve kalitesinin artırılmasında yeterli ve dengeli beslenme ...
