ORCID "0000-0003-2776-5807" Makale Koleksiyonu için listeleme
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Bioconjugated beta-cyclodextrin-perfluorohexane nanocone clusters as functional nanoparticles for nanoparticle-mediated histotripsy
Toydemir, Cemran; Hall, Sarah; Demirel, Erhan; Elmacı, Dilşah Nur; Göl, Deniz; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin (American Chemical Society, 2022)Nanocone clusters (NCCs) are new-generation agents of nanoparticle-mediated histotripsy (NMH) recently developed to address the limitations of previously designed nanodroplets (NDs). NCCs can be obtained by simply mixing ... -
Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei
Edsall, Connor; Khan, Zerin Mahzabin; Mancia, Lauren; Hall, Sarah; Mustafa, Waleed; Johnsen, Eric; Klibanov, Alexander L.; Yüksel Durmaz, Yasemin; Vlaisavljevich, Eli (Elsevier Science Inc, 2021)The study described here examined the effects of cavitation nuclei characteristics on histotripsy. Highspeed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from ... -
Development of acoustically active nanocones using the host-guest interaction as a new histotripsy agent
Rehman, Tanzeel Ur; Khirallah, Jennifer; Demirel, Erhan; Howell, Justin; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin (American Chemical Society, 2019)Histotripsy is a noninvasive and nonthermal ultrasound ablation technique, which mechanically ablates the tissues using very short, focused, high-pressured ultrasound pulses to generate dense cavitating bubble cloud. ... -
Effective PEGylation method to improve biocompatibility of graphene derivatives
Demirel, Erhan; Karaca, Ezgi; Yüksel Durmaz, Yasemin (Elsevier, 2020)The research on the use of graphene (G) in the biological applications has increased exponentially with emerging concerns regarding its biosafety and potential cytotoxicity. The modification of the surface with biocompatible ... -
Effects of droplet composition on nanodroplet-mediated histotripsy
Vlaisavljevich, Eli; Aydın, Ömer; Durmaz Yüksel, Yasemin; Lin, Kuang-Wei; Fowlkes, Brian; Xu, Zhen; ElSayed, Mohamed E. H. (Elsevier Science Inc, 2016)Nanodroplet-mediated histotripsy (NMH) is a targeted ablation technique combining histotripsy with nanodroplets that can be selectively delivered to tumor cells. In two previous studies, polymer-encapsulated perfluoropentane ... -
Effects of ultrasound frequency on nanodroplet-mediated histotripsy
Vlaisavljevich, Eli; Aydın, Ömer; Yüksel Durmaz, Yasemin; Lin, Kuangwei; Fowlkes, Brian; Elsayed, Mohamed; Xu, Zhen (Elsevier Science, 2015)Nanodroplet-mediated histotripsy (NMH) is a targeted ultrasound ablation technique combining histotripsy with nanodroplets that can be selectively delivered to tumor cells for targeted tumor ablation. In a previous study, ... -
Experimental and computational investigation of clustering behavior of cyclodextrin-perfluorocarbon inclusion complexes as effective histotripsy agents
Kaymaz, Betül; Mustafa, Waleed; Hall, Sarah; Vlaisavljevich, Eli; Şensoy, Özge; Yüksel Durmaz, Yasemin (American Chemical Society, 2022)Recently developed nanocones (NCs), which are inclusion complexes that are made up of cyclodextrins (CDs) and perfluorocarbons (PFCs), have shown promising results in nanoparticle-mediated histotripsy (NMH) applications ... -
Formulation of acid-sensitive micelles for delivery of cabazitaxel into prostate cancer cells
Aydın, Ömer; Youssef, İbrahim; Durmaz Yüksel, Yasemin; Tiruchinapally, Gopinath; ElSayed, Mohamed E. H. (Amer Chemical Soc, 2016)We report the synthesis of an amphiphilic triblock copolymer composed of a hydrophilic polyethylene glycol) (PEG) block, a central poly(acrylic acid) (PAA) block, and a hydrophobic poly(methyl methacrylate) (PMMA) block ... -
Nanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'
Khirallah, Jennifer; Schmieley, Rebecca; Demirel, Erhan; Ur Rehman, Tanzeel; Howell, Justin; Yüksel Durmaz, Yasemin; Vlaisavljevich, Eli (Institute of Physics Publishing, 2019)Nanoparticle-mediated histotripsy (NMH) is an ultrasound treatment strategy that combines acoustically sensitive nanoparticles with histotripsy. Previous NMH studies using perfluorocarbon (PFC) nanodroplets (ND's), ∼200 ... -
A new strategy for direct solution electrospinning of phosphorylated poly(vinyl chloride)/polyethyleneimine blend in alcohol media
Altınkök, Çağatay; Sağdıç, Gökhan; Dağlar, Özgün; Ercan Ayra, Merve; Yüksel Durmaz, Yasemin; Durmaz, Hakan; Açık, Gökhan (Elsevier Ltd, 2023)Phosphorylated poly(vinyl chloride) (PPVC)/polyethyleneimine (PEI)-based nanofibers were produced via electrospinning in their blended solutions for the first time. For this purpose, PVC was partially converted into PVC-N3 ... -
Noninvasive ablation of prostate cancer spheroids using acoustically-activated nanodroplets
Aydın, Ömer; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin; Xu, Zhen; ElSayed, Mohamed E. H. (Amer Chemical Soc, 2016)We have developed acoustically activated nanodroplets (NDs) using an amphiphilic triblock copolymer, which self-assembles and encapsulates different perfluorocarbons including perfluoropentane (PFP) and perfluorohexane ... -
The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy
Vlaisavljevich, Eli; Aydın, Ömer; Lin, Kuang-Wei; Durmaz Yüksel, Yasemin; Fowlkes, Brian; ElSayed, Mohamed; Xu, Zhen (Iop Publishing Ltd, 2016)Nanodroplet-mediated histotripsy (NMH) is an ultrasound ablation technique combining histotripsy with acoustically sensitive perfluorocarbon (PFC) nanodroplets that can be selectively delivered to tumor cells for targeted ... -
Selective binding of pVTK peptide-and bisphosphonate-functionalized micelles to prostate cancer cells, osteoblasts, and osteoclasts
Aydın, Ömer; Tiruchinapally, Gopinath; Youssef, Ibrahim; Ramaraju, Harsha; Yüksel Durmaz, Yasemin; Kozloff, Kenneth M.; Kohn, David H.; Elsayed, Mohamed E. H. (Andover House, Inc., 2022)This report describes the development of functionalized polymeric micelles encapsulating a chemotherapeutic agent. The results indicate the ability to achieve selective uptake into different cell populations in metastatic ... -
Synergistic inhibition of aggressive breast cancer cell migration and invasion by cytoplasmic delivery of anti-RhoC silencing RNA and presentation of EPPT1 peptide on "smart" particles
Kaushal, Neha; Tiruchinapally, Gopinath; Yüksel Durmaz, Yasemin; Bao, Liwei; Gilani, Rabia; Merajver, Sofia D.; ElSayed, Mohamed E. H. (Elsevier Science Bv, 2018)Overexpression of RhoC protein in breast cancer patients has been linked to increased cancer cell invasion, migration, and metastases. Suppressing RhoC expression in aggressive breast cancer cells using silencing RNA (siRNA) ...