• In vitro measurement of hepatic flow distribution in Fontan vascular conduits: Towards rapid validation techniques 

  Rasooli, Reza; Köse, Kevser Banu; Lashkarinia, S. Samaneh; Şaşmazel, Ahmet; Pekkan, Kerem (Elsevier Ltd, 2022)

  Fontan operation is the last stage of single-ventricle surgical reconstructions that connects superior and inferior vena cava (SVC, IVC) to the pulmonary arteries. The key design objectives in total cavopulmonary connections ...

• Characterization of biological molecule–loaded nanostructures using circular dichroism and fourier transform infrared spectroscopy 

  Parlar, Ayhan; Kulabhusan, Prabir Kumar; Kurt, Hasan; Gürel, Büşra; Torabfam, Milad; Özata, Başak; Yüce, Meral (Taylor and Francis, 2021)

  Drug-loaded nanoparticles have many advantages in drug administration, which is an essential step for the impact of the drugs and their mechanism of action. Circular dichroism (CD) is a spectroscopy technique that measures ...

• Temperature and pH-dependent behaviors of mAb drugs: A case study for trastuzumab 

  Sert, Fatma; Hız, Defne; Gülmez, Mert; Cankurtaran, Selen Ezgi; Kayalan, Cemre Irmak; Kurt, Hasan; Yüce, Meral (MDPI, 2022)

  The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. ...

• Mechanistic insight into impact of phosphorylation on dynamics of farnesyltransferase: Targeting the protein under hyperinsulinemia 

  Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Cell Press, 2022)

  ...

• A behavioral paradigm for cortical control of a robotic actuator by freely moving rats in a one-dimensional two-target reaching task 

  Zaidi, Syed Muhammad Talha; Kocatürk, Samet; Baykaş, Tunçer; Kocatürk, Mehmet (Elsevier B.V., 2022)

  Background: Controlling the trajectory of a neuroprosthesis to reach distant targets is a commonly used brain-machine interface (BMI) task in primates and has not been available for rodents yet. New method: Here, we describe ...

• Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer 

  Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)

  Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...

• Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites 

  İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)

  Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ...

• Combining multiple clustering and network analysis for discoveries in gene expression data 

  Alhajj, Sleiman; Alhajj, Aya; Tarıyan Özyer, Sibel (Association for Computing Machinery, Inc, 2021)

  Clustering is a challenging research task which could benefit a wide range of practical applications, including bioinformatics. It targets success by optimizing a number of objectives, a characteristic mostly ignored by ...

• A python code for maximum likelihood estimation of the location and scale parameters of the truncated normal distribution 

  Ögütcen, Melih Yılmaz; Kocatürk, Mehmet; Okatan, Murat (Institute of Electrical and Electronics Engineers Inc., 2021)

  Extracellular neural recordings obtained from chronically implanted microelectrode arrays are widely used in behavioral neurophysiology and invasive brain-machine interfaces. After the raw recordings are band-pass filtered ...

• Using Johnson's SU distribution for modeling the background activity in extracellular neural recordings 

  Ögütcen, Melih Yılmaz; Kocatürk, Mehmet; Okatan, Murat (Institute of Electrical and Electronics Engineers Inc., 2021)

  Extracellular neural recordings obtained from awake behaving subjects through chronically implanted microelectrode arrays provide information about the functioning of the brain with sub-millisecond temporal resolution at ...

• Investigation into cervical spine biomechanics following single, multilevel and hybrid disc replacement surgery with dynamic cervical implant and fusion: A finite element study 

  Mumtaz, Muzammil; Zafarparandeh, Iman; Erbulut, Deniz Ufuk (Multidisciplinary Digital Publishing Institute (MDPI), 2022)

  Cervical fusion has been a standard procedure for treating abnormalities associated with the cervical spine. However, the reliability of anterior cervical discectomy and fusion (ACDF) has become arguable due to its adverse ...

• Can Carpobrotus edulis, heal incisional and excisional wounds on the skin? 

  Günal, Mehmet Yalçın; Şahinler Ayla, Sibel; Çaglayan, Berrak; Beker, Mustafa Çağlar; Bedri, Nejda; Aslan, İpek Bilge; Özdemir, Ekrem Musa; Kılıç, Ertuğrul; Yeşilada, Elif (Comenius University, 2021)

  OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, ...

• Nanoplasmonic biosensors: Theory, structure, design, and review of recent applications 

  Kurt, Hasan; Pishva, Parsa; Pehlivan, Zeki Semih; Arsoy, Elif Gül; Saleem, Qandeel; Bayaz, Mustafa Kemal; Yüce, Meral (Elsevier, 2021)

  Nanoplasmonic biosensing shows an immense potential to satisfy the needs of the global health industry -low-cost, fast, and portable automated systems; highly sensitive and real-time detection; multiplexing and miniaturization. ...

• Clinical evaluation of decompressive craniectomy in malignant middle cerebral artery infarction using 3d area and volume calculations 

  Kitiş, Serkan; Çevik, Serdar; Köse, Kevser Banu; Baygül, Arzu; Cömert, Serhat; Ünlü Ünsal, Ülkü; Gündağ Papaker, Meliha (Wolters Kluwer Medknow Publications, 2021)

  Objective: We aimed to measure the craniectomy area using three-dimensional (3D) anatomic area and volume calculations to demonstrate that it can be an effective criterion for evaluating survival and functional outcomes ...

• Microwave-promoted continuous flow systems in nanoparticle synthesis-A perspective 

  Saleem, Qandeel; Torabfam, Milad; Fidan, Tuçe; Kurt, Hasan; Yüce, Meral; Clarke, Nigel; Bayazıt, Mustafa Kemal (American Chemical Society, 2021)

  Microwave-promoted continuous flow systems have emerged as a game-changer in nanoparticle synthesis. Owing to the excellent compatibility between fast, sustainable microwave heating and one-step, efficient flow chemistry, ...

• Sağlık teknolojisi değerlendirmede çok kriterli karar verme yaklaşımları üzerine bir derleme çalışması 

  Almula Karadayı, Melis; Yılmaz, Beyza Özlem; Erol, Bilgehan Eren; Tozan, Hakan (Düzce Üniversitesi, 2020)

  Sağlık sektöründe yer alan ilaçlar, tıbbi tedavi prosedürleri, tıbbı cihazlar, cerrahi teknikler ve sağlık sistemleri Sağlık Teknolojisi Değerlendirme (STD) kapsamında değerlendirilmektedir. Bu tip sağlık teknolojilerinin ...

• An MCDM-based health technology assessment (HTA) study for evaluating kidney stone treatment alternatives 

  Erol, Eren; Yılmaz, Beyza Özlem; Almula Karadayı, Melis; Tozan, Hakan (Springer Science and Business Media Deutschland GmbH, 2021)

  The prevalence of kidney stone disease has increased during the last decade due to various reasons such as changes in dietary and water consumption. To overcome this issue, new treatment approaches are being developed. ...

• Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei 

  Edsall, Connor; Khan, Zerin Mahzabin; Mancia, Lauren; Hall, Sarah; Mustafa, Waleed; Johnsen, Eric; Klibanov, Alexander L.; Yüksel Durmaz, Yasemin; Vlaisavljevich, Eli (Elsevier Science Inc, 2021)

  The study described here examined the effects of cavitation nuclei characteristics on histotripsy. Highspeed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from ...

• Öğrenci mikroskobunda epifloresan görüntüleme 

  Gökduman, Selcen Necibe (Institute of Electrical and Electronics Engineers Inc., 2020)

  Fluorescence microscopy is used as an important tool for research and education in the biological sciences. Fluorescence microscopes allow fluorescent signal to be obtained by stimulating markers in biological samples using ...

• Quantitative phase macroscopic system for label-free imaging of tissue sections 

  Toy, Muhammed Fatih (İstanbul University, 2021)

  Optical microscopes are typically designed as versatile tools that are capable of imaging at various modalities with different resolutions in respective visual fields. A large extend of versatility causes increased complexity, ...

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